8,691 research outputs found
Real Pictures : Photographs From the Collection of Claudia Beck and Andrew Gruft
No full text"The Vancouver Art Gallery has acquired a major art collection valued at $2 million (CDN) consisting of over 460 exceptional photographic images by some of the world’s most acclaimed photographers. The acquisition, from the collection of Claudia Beck and Andrew Gruft, comprises rare and vintage prints by some of the most recognized figures in the history of photography including Ansel Adams, Manuel Alvarez Bravo, Margaret Bourke-White, Julia Margaret Cameron, Robert Capa, Henri Cartier-Bresson, Walker Evans, Robert Frank, Andrea Kertesz, Dorothea Lange, Nadar, August Sander, Aaron Siskind, Alfred Stieglitz and Garry Winogrand." -- Publisher's website
Open access to large scale datasets is needed to translate knowledge of cancer heterogeneity into better patient outcomes.
No full textIn this guest editorial, Andrew Beck discusses the importance of open access to big data for translating knowledge of cancer heterogeneity into better outcomes for cancer patients
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Precision Cancer Diagnostics: Tracking Genomic Evolution in Clinical Trials.
No full textIn a Perspective, Francisco Beca and Andrew Beck discuss Charles Swanton and colleagues' accompanying Research Article on somatic mutations in patients with inflammatory breast cancer treated in a Phase II clinical trial
"Plasmodium falciparum" transfection technology for the analysis of "var" gene regulation and knockout investigation
No full textMalaria is an infectious disease caused by protozoans of the genus
Plasmodium, which are injected by the bite of an infected female Anopheles
mosquito during a blood meal. Out of the four species that infect humans, P.
falciparum is the most important. About 40% of the world’s population is at
risk and 500 million cases of malaria occur every year, mainly in sub-
Saharan Africa. Due arising resistance of mosquitoes against insecticides,
the lack of a malaria vaccine, and emerging resistance of parasites against
established drugs, research into new drugs and vaccine targets is most
important.
Morbidity is associated with adherence of infected red blood cells (iRBC) to
endothelial tissue thereby obstructing the blood flow. The major protein
conferring this cytoadherence is the P. falciparum erythrocyte membrane
protein 1 (PfEMP1) anchored in the erythrocyte membrane of infected red
blood cells (iRBCs). PfEMP1 is encoded by the var gene family that consists
of approximately 60 members in the haploid genome of the 3D7 strain. var
genes are expressed mutually exclusive, i.e. only one var gene is expressed
in a parasite at a time and the rest is silenced. In this thesis we were
interested in the regulation of expression and silencing of var genes. For this
purpose we generated transgenic parasite lines that harbored plasmids
expressing luciferase under the control of various fragments of the var gene
upstream region. By comparing luciferase activities in the different lines we
identified the core promoter, two activator-binding sites and a repressorbinding
site. Additionally, we identified a regulatory sequence on the var
upstream region that interacts with the var intron during silencing. Using
quantitative RT-PCR with specific primers for every var gene we were unable
to confirm that the var upstream regions on the transfected plasmids were
recognized by the machinery that ensures mutually exclusive transcription.
In the second part of this thesis, we evaluated phosphodiesterase 1 (PDE1)
as a possible drug target in P. falciparum by creating a knockout parasite
line. PDEs are known drug targets in humans where selective PDE inhibitors
are being used to treat a wide range of diseases. In trypanosomiasis
research PDE inhibitors are promising drug candidates against sleeping
sickness, Nagana or Chagas’ disease. Out of the four PDEs described for P.
falciparum we focused on PfPDE1, which is expressed in blood stage
parasites and in gametocytes and sporozoites. We observed a slightly faster
growth of the knockout parasite line compared to the wildtype indicating that
the knockout parasite had a shorter erythrocytic lifecycle. We found that
PfPDE1 is responsible for 20% of the total cGMP activity observed in late
blood stage parasites and that there is no rescue mechanism of the
remaining PDEs to compensate for the loss of activity. We were not able to
localize PfPDE1 in the parasite. The fact that we could delete PfPDE1 clearly
shows that it is not an essential gene in blood stage forms of P. falciparum
and hence not a good drug target. Nevertheless we created a useful tool to
investigate the role of PfPDE1 in the development of sexual parasite forms
Beck, Andrew George (Birth, 1911-08-30)
No full textAddress: 1347 Main St.4713/1911Original record filed in drawer labeled 'BEALS-BECK'
Beck, Andrew (Death, 1877-05-07)
No full textAddress: Plum St.Age at death: 49 yrsPg 19/84/1877/M W M/City/Dr. W. Davis/J. Wiltsee/St. Joseph's NewOriginal record filed in drawer labeled 'BEALS-BECK'
Agent (Capt.) Beck to Commissioner
No full textUteLetter regards a purported \u27antogonism\u27 from White River Utes to the author, Agent Beck. Marisco
The Legacy of Ulrich Beck in Asia: Introduction
No full textThis introduction briefly describes the relational trajectory between Ulrich Beck and Asia in the last few years. It draws particular attention to his last words about the role of Asia in the global risk community. Beck began to speak of the concept of metamorphosis in the 2014 Seoul conference as the correct key to understanding emancipatory catastrophism that he had expressed in the 2013 Potsdam conference. He was fascinated by the explanatory power of this concept and was driven to complete a book to explain the cosmopolitan change of the world from this perspective. With his advocacy of cities as cosmopolitan transformers, he urged Asian cities, particularly Seoul, to initiate United Cities of Asia' for a cosmopolitan cooperation for risk governance. Beck also suggested a parliament of risk actors' as a practical task to be realized in the future. In this introduction the author attempts to trace back the formation of these ideas by focusing on the interaction between Beck and Asia before his sudden passing.A&[email protected]
Underline I & II (at Beyond Beck Road)
No full textBeyond Beck Road (part of Open House Festival London and European Heritage Days) is a free public art event, where the street becomes a living breathing exhibition space.
The street is a communal stage for artistry, embracing inclusivity, participation and collaboration, through workshops and public exhibition. The event’s participants and artists are all connected to the street and surrounding area and encompass emerging and established creatives if all ages.
Beck Road itself houses resident artists, studios and has significant communal and cultural heritage. The event’s configuration, of individual and collaborative work, reflects its location in the heart of Hackney, as a vibrant and culturally expansive borough.
Beyond Beck Road culminates with Underline, a performative screening event, which takes place in the railway arch that divides the street. For this event it is transformed into a unique cinema space. Its programme combines an open call, short films, expanded cinema and performances in a distinct sensory encounter
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