1,721,193 research outputs found
Editorial [Hot topic: Bioactive Azoles with Three Heteroatoms (Guest Editor: Dr. Andrea Pace)]
No full textDispositivo integrato per la purificazione di corpi idrici mediante tecniche fotochimiche
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
COMBINING TRANSLATION READTHROUGH INDUCING DRUGS AND NONSENSE MEDIATED DECAY PATWHAY INHIBITION TO THE CFTR RESCUE IN CYSTIC FIBROSIS CELL MODEL SYSTEM
Full text linkNonsense mutations affect 10% of patients with cystic
fibrosis and produce a premature termination codon in CFTR
(Cystic Fibrosis Transmembrane Conductance Regulator)
mRNA causing early termination of translation and leading to
lack of CFTR function. A potential therapy for nonsense mutations provides the use of small molecules able to overcome the
premature stop codon (PTC) by a readthrough mechanism that
lead to synthesis a complete CFTR protein. Despite the good
results obtained from this approach, TRIDs efficiency is considerably reduced by the poor amount of target transcript, that is
the mRNA containing the PTC. The readthrough, indeed, does
not occur on the totality of target transcripts because of their
degradation due to the nonsense mediated decay pathway
(NMD). This pathway provides the degradation of mRNA harboring premature stop codon to prevent the production of
altered polypeptides. In contrast, the activity of this pathway
interferes with the effectiveness of the readthrough drugs, limiting the mRNA concentration of the target protein. Thus, a
promising strategy for nonsense mutation treatment is a combined use of readthrough agents and factors that attenuate the
nonsense mRNA decay. By silencing the UPF1 mRNA/protein, the activity of the NMD pathway was reduced, in FRT
cells CFTR W1282X. Alternatively, caffeine was used as specific
inhibitor of the UPF1 activity, to increase the efficiency of
readthrough molecules (NV848 and NV914) in FRT cells
CFTRW1282X cells. In both cases, the combined treatment:
NV848 or NV914/caffeine and NV848 or
NV914/UPF1siRNA caused an increase of CFTRW1282X
mRNA level followed by the rescue of the CFTR expression
and functionality. However, unexpectedly, despite the higher
CFTRW1282X mRNA level in caffeine treated samples, both
expression and functionality CFTR rescue resulted slightly
lower than the recovery achieved by UPF1 silencing. Our
results indicate that modulation of NMD pathway, although
still to be optimized, could be a promising approach in order
to increase TRIDs effects in presence of stop mutations
NOVEL SMALL MOLECULES THAT BIND AND/OR MODULATE DIFFERENT FORMS OF TAU OLIGOMERS
No full textThe present invention relates to novel small molecules of Formulas I, II, III, IIIa, IIIb, and IV and pharmaceutically acceptable salts thereof, as well as the preparation and the use thereof
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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