1,720,969 research outputs found
Auxological tools for following growth in extreme short stature and for evaluating growth promoting interventions
No full textGrowth charts are inevitable tools for following children in clinical practice and also when evaluating growth promoting therapy. Growth is a concern especially for families to children of extreme short stature such as in skeletal dysplasias but evaluations of growth pattern with changes in height position is complicated when height develops far below normal population range. Height gain from growth hormone therapy is variable for short stature conditions without aberrant growth hormone secretion such as in Turner syndrome. This makes it difficult to communicate realistic adult height estimates to concerned families.The first part of this PhD project used semi-longitudinal data from 4,375 measuring occasions to construct growth and body proportion references for achondroplasia and to describe these in relation to normal population references. Typical for achondroplasia, tempo in head size was increased attaining final size earlier than normal. Height was at the same time compromised with major loss in height position during the first years of life, due to limited growth capacity of the legs. At adult ages, leg length was half of that in normal population and arm span almost 35 percent lower than normal contributing to severely reduced area of personal access. Pronounced body disproportions distort the BMI-value in achondroplasia, which is why specific BMI charts were constructed. Clinical achondroplasia charts were developed to support surveillance of these children and, as short stature matrix, possibly also for other children with severe short stature for which syndrome-specific charts are missing. The usability of these achondroplasia charts were tested by illustrating growth pattern of selected skeletal dysplasias. Obtained achondroplasia references for height, sitting height, leg length and arm span might contribute to a better understanding of the effect of FGFR3 signalling on growth and will also be inevitable tools for evaluation of novel treatments.In the second part, variability in response to growth hormone therapy was studied by dividing a sample of 455 girls with Turner syndrome, reported in the Swedish National Register for growth hormone treatment of children and adolescents, into good and poor response based on the distribution of total height gain from treatment. As age at treatment initiation was distributed over almost entire growth period, the sample was further grouped into those with treatment start during normally prepubertal and pubertal ages. Differences of clinical relevance were higher mid-parental height, higher GH dose at 12 months of treatment and improved body proportions in the younger good response group; and younger age and shorter height position at treatment initiation and higher GH dose in the older good response group. These findings could possibly be influenced by subgroups identified in graphic presentations. Initial height gain from treatment did not necessarily translate into better total height gain neither in younger or older poor groups. In contrast to previous claims, early initiation of growth hormone treatment per se did often not result in better total height gain.List of scientific papersI. Andrea Merker, Luitgard Neumeyer, Niels Thomas Hertel, Giedre Grigelioniene, Outi Mäkitie, Klaus Mohnike, Lars Hagenäs. Growth in achondroplasia: Development of height, weight, head circumference, and body mass index in a European cohort. American Journal of Medical Genetics Part A. 2018 (176): 1723-1734. https://doi.org/10.1002/ajmg.a.38853 II. Andrea Merker, Luitgard Neumeyer, Niels Thomas Hertel, Giedre Grigelioniene, Klaus Mohnike, Lars Hagenäs. Development of body proportions in achondroplasia: Sitting height, leg length, arm span, and foot length. American Journal of Medical Genetics Part A. 2018 (176): 1819-1829. https://doi.org/10.1002/ajmg.a.40356 III. Luitgard Neumeyer, Andrea Merker, Lars Hagenäs. Clinical charts for surveillance of growth and body proportion development in achondroplasia. [Manuscript]IV. Andrea Merker, Luitgard Neumeyer, Mariana del Pino, Virginia Fano, Giedre Grigelioniene, Karen Heath, Purificación Ros-Perez, Ana Coral Barreda-Bonis, Isabel González Casado, Enrique Galán, Niels Thomas Hertel, Outi Mäkitie, Robert C. Olney, Lars Hagenäs. Using Achondroplasia growth chart as matrix for following children with skeletal dysplasia and extreme short stature. [Manuscript]V. Andrea Merker, Jovanna Dahlgren, Svante Norgren, Lars Hagenäs. Good and poor response to growth hormone treatment – an auxological evaluation of a cohort with Turner syndrome. [Manuscript]</p
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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