1,207 research outputs found
Stock ownership and corporate performance in Japan: Corporate governance by institutional investors
No full textFaced with an aging population and a low fertility rate, Japan finds it increasingly essential to shift diminishing national savings into productive investment in order to preserve the dynamism of its economy. Stock investment by institutional investors is important for corporate financing, and shareholder involvement in governance influences corporate growth. Using panel data for Japan's listed companies and foreign investors' votes on shareholder proposals, this paper demonstrates: (1) an increase in stock ownership by foreign investors' had a positive effect on productivity growth, but it has not recently improved other corporate performance indices, and (2) foreign investors' strong attitudes towards voting had a positive effect on productivity growth. This paper concludes that external stakeholders' active, qualitative involvement in corporate governance and their quantitative involvement by increasing stock ownership are key to improving corporate growth.
GC Separation of cis-Eicosenoic Acid Positional Isomers on an Ionic Liquid SLB-IL100 Stationary Phase
No full textGas chromatography (GC) of cis-eicosenoic acid (20:1) positional isomers has been investigated on a capillary column of ionic liquid 1,9-di(3-vinyl-imidazolium)nonane bis(trifluoromethyl)sulfonylimidate stationary phase (SLB-IL100). A test mixture of isomeric 20:1 methyl esters was prepared from flathead flounder flesh lipids. On a 60-m column operated at 150-180 °C, six peaks appeared in the elution order of 20:ln-15 → 20:ln-13 → 20:ln-11 → 20:ln-9 → 20:ln-7 → 20:ln-5. These peaks were baseline resolved within 20 min at 180 °C. The 20:ln-13 and 20:ln-11 isomers, poorly resolved on conventional polar polysiloxane stationary phases, were completely separated from each other with separation factor α = 1.02 and peak resolution (Rs) >- 1.57. When equivalent chain length (ECL) values were compared between the SLB-IL100 and CP-Sil 88 (biscyanopropyl polysiloxane), those of 20:ln-15 and 20:ln-13 exceptionally tended to be lower on the SLB-IL100. The excellent separation of 20:1 isomers seems due to less retention of 20:ln-15 and 20:ln-13 on SLB-IL100 rather than simply due to its high polarity. Analysis of herring oil 20:1 revealed the occurrence of 20:ln-13 in the Pacific herring but not in the Atlantic herring. The ionic liquid stationary phase, SLB-IL100, is effective for analyzing 20:1 isomers occurring in fish and other natural oils
Comparison of quantitative measurements of central nervous system tumour consistency and the associated preoperative imaging findings
No full text主査 : 船橋公彦 / タイトル : Comparison of quantitative measurements of central nervous system tumour consistency and the associated preoperative imaging findings /著者 : Hiroyuki Masuda, Masaaki Nemoto, Naoyuki Harada, Yutaka Fuchinoue, Shinichi Okonogi, Yasuhiro Node, Shunpei Ando, Kosuke Kondo, Nobuo Sugo /掲載誌 : British Journal of Neurosurgery /巻号・発行年等 : 33(5): 522-527, 2019 /本文ファイル: 査読後原
サメガレイClidoderma asperrimum の筋肉脂質における全-cis-5,8,11,14,17,20,23-ヘキサコサヘプタエン酸（26:7n-3）の存在
No full textFatty acid analysis of roughscale sole Clidoderma asperrimum flesh lipids was carried out by gas chromatography. An unidentified peak appeared in the chromatogram in the elution region of ≥C24 fatty acids. After enrichment by solvent partitioning, reversed-phase thin-layer chromatography (TLC), and argentation TLC, the peak component was subjected to structural analyses. The partially hydrogenated products after reaction with hydrazine hydrate gave seven isomers of cis-hexacosenoic acid (26:1). Gas chromatography-mass spectrometry (GC–MS) analyses of their dimethyl disulfide adducts identified the monounsaturates as 5-, 8-, 11-, 14-, 17-, 20-, and 23-26:1. The peak component was assigned to all-cis-5,8,11,14,17,20,23-hexacosaheptaenoic acid (26:7n-3). GC–MS analyses of the 4,4-dimethyloxazoline derivative and methyl ester confirmed this structure. This fatty acid is a rare, very long-chain polyunsaturated fatty acid (VLCPUFA). The concentrations of the acid found in roughscale sole were 0.69 ± 0.34% (N = 5) of total fatty acids in flesh lipids. Roughscale sole appears to be characterized by the occurrence of 26:7n-3, which is lacking in popular sources of methylene-interrupted VLCPUFA, such as vertebrate retina, spermatozoa, and herring. 北海道産サメガレイの筋肉脂質の脂肪酸をGC で分析したところ，炭素数24 以上の領域に未知のピークが出現した。この成分を濃縮後，数種の誘導体に変換してGC-MSに供した結果，同成分は全-cis-5,8,11,14,17,20,23-ヘキサコサヘプタエン酸（26:7n-3）と同定された。総脂肪酸中の含有量は供試5 個体の平均で0.69±0.34％であった。サメガレイは，n-3 系およびn-6 系超長鎖ポリエン酸の給源として一般的な高等動物の網膜，精子，ニシン油などには見られない26:7n-3 を含む点で特徴的である
Reinvestigation of positional distribution of tetracosahexaenoic acid in triacyl-sn-glycerols of flathead flounder flesh
No full textPositional distribution of fatty acids in triacyl-sn-glycerols (TAG) of the flathead flounder Hippoglossoides dubius has been reinvestigated in order to accurately determine the contents of tetracosahexaenoic acid (24:6n-3) in the sn-1, sn-2, and sn-3 positions. Flesh TAG obtained from three flounders were subjected to stereospecific analysis using a suitable procedure for fish TAG analysis. The 24:6n-3 acid was found in the three positions at the concentrations of 0.3--5.5 mole% (the sn-1 position), 1.6--23.3 mole% (the sn-2 position), and 0.6--8.9 mole% (the sn-3 position). In contrast to a previous analysis, the present analysis revealed that 24:6n-3 is preferentially esterified in the sn-2 position followed by the sn-3 and sn-1 positions. Other polyunsaturated fatty acids, docosahexaenoic acid (22:6n-3; DHA) and docosapentaenoic acid (22:5n-3; DPA), showed a similar distribution pattern. These results indicate that the general tendency observed for long-chain polyunsaturated fatty acids in marine fish TAG can be extended to the distribution of 24:6n-3 in flathead flounder TAG. Because the use of flathead flounders is entirely for human food, we thus intake 24:6n-3 concentrated in the sn-2 position of their TAG
Effects of Participatory and Physical Life Goals in a Preventive Care Program for Frail Community-Dwelling Older People: A Retrospective Cohort Study
No full textAbstract
Date Presented 3/31/2017
Life goals related to activities and participation had a more positive effect on frail older people’s health and quality of life than did life goals related to physical function and structure. The setting of meaningful goals may help to improve the effectiveness of preventive care programs.
Primary Author and Speaker: Yoshimi Yuri
Additional Authors and Speakers: Shinichi Takabatake, Yoko Tsuji, Yuri Fujii, Toshikatsu Kaneda, Yasuhiro Higashi, Hiroko Hashimoto, Kazuyo Nakaoka, Mari Oka</jats:p
Synthesis of Urethane Derivatives of Mono- and Diacylglycerols for Use as HPLC Standards in the Enantiomeric Separation
No full textThis paper presents a convenient method for the preparation of reference standards for high-performance liquid chromatography (HPLC) used in stereospecific analysis of triacyl-sn-glycerols via monoacylglycerol or diacylglycerol intermediates. In the analysis, these partial acylglycerols are separated into their respective positional and enantiomeric isomer classes by chiral HPLC as their 3,5-dinitrophenylurethane derivatives or by silicic acid HPLC as their (S)- or (R)-1-(1-naphthyl)ethyl urethane derivatives. In this study, these urethane derivative standards were synthesized by the following novel procedure: first, partial urethane derivatives of glycerol were prepared by carbamoylation of glycerol with isocyanates; secondly, the products were separated into positional isomer classes by silicic acid HPLC, and; finally, a fatty acid was added to the partial urethanes using N,N'-dicyclohexylcarbodiimide. The identities of the resulting urethane derivatives of glycerol were verified by mass spectrometry and HPLC. This new procedure is advantageous in that standard urethane derivatives of partial acylglycerols can be synthesized from no more than 50 mu g of fatty acids. This benefit is especially important in the case of rare and expensive fatty acids, such as very long chain polyunsaturated fatty acids, tetracosahexaenoic acid, and hexacosaheptaenoic acid, found in marine lipids
Individual variations in fatty acid composition and concentration as indicators of the nutritional condition of wild pointhead flounder larvae
No full textWe investigated the fatty acid compositions and concentrations of wild marine fish larvae with a highly accurate method because our knowledge of them has been seriously limited compared with cultured larvae. This study presents estimates of the fatty-acid-based nutritional condition of individual larvae in the field. Because the pointhead flounder Cleisthenes pinetorum displays relatively high stock size fluctuations, we investigated the developmental change in the fatty acid compositions of the body trunk, head, and eye and the annual fluctuations in the fatty acid concentrations in the trunk. We show that the process of fatty acid accumulation is not uniform across body parts and that the trunk is a better indicator of larval nutritional status than other parts because there is less time lag. Starved larvae with simultaneously high docosahexaenomic acid ratios and low total fatty acid concentrations, as observed in laboratory experiments, are rare in the wild. Thus, starved larvae must be removed rapidly by predators before they can experience a relatively long period of starvation in the wild. Fatty acid accumulation was greater in the larvae of the 2005 year class than in those of the 2006 year class in their first feeding stage, according to the optimal model derived with generalized linear model. A previous study indicated that the 2005 year class showed stronger recruitment than the 2006 year class. We conclude that the fatty acid analysis of wild larvae is a useful index of their nutritional status and mortality, especially in the first feeding stage
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045]
Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression
No full text近畿大学Kindai University博士（医学）主査：岡田 斉 教授
学内授与番号：医第1425号This is a pre-copyedited, author-produced version of an article accepted for publication in [International Immunology] following peer review. The version of record [Yasuhiro Masuta, Kosuke Minaga, Masayuki Kurimoto, Ikue Sekai, Akane Hara, Naoya Omaru, Natsuki Okai, Yasuo Otsuka, Ryutaro Takada, Tomoe Yoshikawa, Sho Masaki, Ken Kamata, Hajime Honjo, Yasuyuki Arai, Kouhei Yamashita, Masatoshi Kudo, Tomohiro Watanabe "Activation of nucleotide-binding oligomerization domain 2 by muramyl dipeptide negatively regulates Toll-like receptor 9-mediated colonic inflammation through the induction of deubiquitinating enzyme A expression" International Immunology, Volume 35, Issue 2, February 2023, Pages 79–94] is available online at: [https://doi.org/10.1093/intimm/dxac045].doctoral thesi
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