124,853 research outputs found
Can competition between the crystal field and the Kondo effect cause non-fermi-liquid-like behavior?
No full textThe recently reported unusual behavior of the static and dynamical magnetic susceptibility as well as the specific heat in Ce1-xLaxNi9Ge4 has raised the question of a possible non-Fermi-liquid ground state in this material. We argue that for a consistent physical picture the crystal-field splitting of two low-lying magnetic doublets of the Ce 4f-shell must be taken into account. Furthermore, we show that for a splitting of the order of the low temperature scale T- of the system a crossover behavior between an SU(4) and an SU(2) Kondo effect is found. The screening of the two doublets occurs on different temperature scales leading to a different behavior of the magnetic susceptibility and the specific heat at low temperatures. The experimentally accessible temperature regime down to 50 mK still lies in the extended crossover regime into a strong-coupling Fermi-liquid fixed point
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.
Get PDFInnate immune activation via IL-1R or Toll-like receptors (TLR) contibutes to acute kidney injury but its role in tissue remodeling during chronic kidney disease is unclear. SIGIRR is an inhibitor of TLR-induced cytokine and chemokine expression in intrarenal immune cells, therefore, we hypothesized that Sigirr-deficiency would aggravate postobstructive renal fibrosis. The expression of TLRs as well as endogenous TLR agonists increased within six days after UUO in obstructed compared to unobstructed kidneys while SIGIRR itself was downregulated by day 10. However, lack of SIGIRR did not affect the intrarenal mRNA expression of proinflammatory and profibrotic mediators as well as the numbers of intrarenal macrophages and T cells or morphometric markers of tubular atrophy and interstitial fibrosis. Because SIGIRR is known to block TLR/IL-1R signaling at the level of the intracellular adaptor molecule MyD88 UUO experiments were also performed in mice deficient for either MyD88, TLR2 or TLR9. After UUO there was no significant change of tubular interstitial damage and interstitial fibrosis in neither of these mice compared to wildtype counterparts. Additional in-vitro studies with CD90+ renal fibroblasts revealed that TLR agonists induce the expression of IL-6 and MCP-1/CCL2 but not of TGF-β, collagen-1α or smooth muscle actin. Together, postobstructive renal interstitial fibrosis and tubular atrophy develop independent of SIGIRR, TLR2, TLR9, and MyD88. These data argue against a significant role of these molecules in renal fibrosis
Synthesis of bis- and tris(indolinylidenemethyl)benzenes by one-pot reactions of polylithiated nitriles with bis(imidoyl)chlorides of oxalic acid
No full textThe reaction of polylithiated di- and tricyanomethylbenzenes with oxalic acid-bis (imidoyl) chlorides afforded novel oligo(indolinylidenemethyl) benzenes with the formation of up to six carbon-carbon bonds. The UV/Vis spectroscopic features of these and related compounds were studied. 1,4-Disubstituted benzenes containing a large pi-system have been efficiently prepared by the reaction of dianions with 1,4-dicyanobenzene
Synthesis of bis- and tris(indolinylidenemethyl)benzenes by one-pot reactions of polylithiated nitriles with bis(imidoyl)chlorides of oxalic acid
No full textThe reaction of polylithiated di- and tricyanomethylbenzenes with oxalic acid-bis (imidoyl) chlorides afforded novel oligo(indolinylidenemethyl) benzenes with the formation of up to six carbon-carbon bonds. The UV/Vis spectroscopic features of these and related compounds were studied. 1,4-Disubstituted benzenes containing a large pi-system have been efficiently prepared by the reaction of dianions with 1,4-dicyanobenzene
ChemInform Abstract: Synthesis of Bis- and Tris(indolinylidenemethyl)benzenes by One-Pot Reactions of Polylithiated Nitriles with Bis(imidoyl)chlorides of Oxalic Acid.
No full textAnders Munk. — Danish Pyrenomycetes. A preliminary Flora, in Dansk Botanisk Arkiv, t. 17, N° 1
No full textAnders Munk. — Danish Pyrenomycetes. A preliminary Flora, in Dansk Botanisk Arkiv, t. 17, N° 1. In: Bulletin mensuel de la Société linnéenne de Lyon, 27ᵉ année, n°3, mars 1958. p. 88
Anders Munk. — Danish Pyrenomycetes. A preliminary Flora, in Dansk Botanisk Arkiv, t. 17, N° 1
No full textAnders Munk. — Danish Pyrenomycetes. A preliminary Flora, in Dansk Botanisk Arkiv, t. 17, N° 1. In: Bulletin mensuel de la Société linnéenne de Lyon, 27ᵉ année, n°3, mars 1958. p. 88
Differential expression analysis for sequence count data
Get PDF*Motivation:* High-throughput nucleotide sequencing provides quantitative readouts in assays for RNA expression (RNA-Seq), protein-DNA binding (ChIP-Seq) or cell counting (barcode sequencing). Statistical inference of differential signal in such data requires estimation of their variability throughout the dynamic range. When the number of replicates is small, error modelling is needed to achieve statistical power.

*Results:* We propose an error model that uses the negative binomial distribution, with variance and mean linked by local regression, to model the null distribution of the count data. The method controls type-I error and provides good detection power. 

*Availability:* A free open-source R software package, _DESeq_, is available from the Bioconductor project and from "http://www-huber.embl.de/users/anders/DESeq":http://www-huber.embl.de/users/anders/DESeq
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