1,721,489 research outputs found
Development of new molecular genetic epidemiological approaches with application to the human growth hormone, insulin-like growth factor I, and leptin receptor genes
No full textThe project had multiple aims: To develop economical and fast methods for the identification of insertion/deletion polymorphisms. Use the developed methods to genotype the 3’UTR 1/D polymorphism in the human leptin receptor gene in a large cohort. To branch out and further the conservative methods of implementation of DNA banks already developed by our laboratory (DOP and L-PCR). Use these developments to perform a cohort study of various polymorphisms in the human GH and IGF1 genes. To develop ARMS assays and perform a cohort study of SNPs in the human GH1 and IGF1 genes. To perform extensive analysis of the data available for the Hertfordshire banks. To analyse the associations, between all the markers used for the methods development, with the various phenotype data available. The main East Hertfordshire database, which contains phenotype data for cardiovascular markers, fasting, bloods, GTT’s lung function, and anthropometrics, and relationship with each genotype found for each SNP in both GH1 and IGF1 genes was also set to be analysed. Genotype-phenotype analysis was intended to be performed for the data available for the East Hertfordshire bone database as well as for the North Hertfordshire database that contains information for ageing markers, blood pressure and anthropometrics. To further expand the investigation of the SNP results by analysis linkage disequilibrium between the GH1 polymorphism and I/D polymorphism in the ACE gene, and LD between the investigated SNP markers in the IGF1 gene.</p
THE FOOD OF THE HAPPY ONES
Get PDFThe paper aims to demonstrate the way food can reflect peoples‘ beliefs and mentalities. We analyze the myth of paradise through the legendary image of the Blajini (the Gentle ones), an ascetic community which appears linked to the Easter celebration. We a lso bring into discussion the tale of Alexander the Great, the myth of Pays de Cocagne and some other Romanian and European writings which concern images of heaven and hell. Each food and each context of feeding presented indicate the different ways in whic h people understand happiness
The Use of Multi-Source Feedback as a Human Resource Management Tool
Get PDFThe article is devoted to the Multiple Source Assessment method as a process of Human Resource Management. Several aspects related to the definition of this method and others concerning its importance, purpose, application and feedback are presented. This method has been used for personal development at the organizational level, and then has begun to be directed to other purposes related of efficiency and performance. The method is considered revolutionary for human resources’ evaluation. It is increasingly used at an international level, with a growing prevalence. Recently, it has also begun to be used in the Romanian companies.multiple source assessment, human resource management, performance
TECHNIQUES OF ANALYSIS AND DIAGNOSTICS OF THE COMPANIES ON THE BASIS OF FINANCIAL INDEX
Get PDFNot only banks do that and all the non-financial firms who want to check the solvability of a company. In this way there were created the scoring models. These models help the decided factors from a company to classify the companies and, depending of the score, to give or not the loan.techniques
Triple negative breast cancer: The kiss of death
Get PDFOne of the most controversial women malignancies, triple negative breast cancers (TNBCs) are critically overviewed here, being focused on data useful in clinical practice or to improve the therapy and patients survival. TNBCs "choose" young women and its "kiss" is, unfortunately deadly in most cases. Currently, few sparse data are available in literature concerning the origins of TNBC. Vasculogenic mimicry detected in TNBCs, seems to be determined by a population of CD133+ cells and may be stimulated by different pharmacological agents such sunitinib. Despite the fact that TNBCs do not usually metastasize through the lymphatic pathways, TNBCs may be characterized by lymphatic invasion and by an increased lymphatic microvascular density. If TNBCs treatment depends on the molecular profile of the tumor, the same statement may be postulated for TNBCs metastasis. Whether metastases have a similar phenotype as the primary tumor remains an enigma. Therefore, the question: 'Could TNBC be subject to a standardized, unanimously accepted therapeutic strategy or is it strictly subclass-dependent?' remains to be further investigated
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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