130,636 research outputs found
Universality of a mesenchymal transition signature in invasive solid cancers
No full textIn this brief communication, additional computational validation is provided consistent with the unifying hypothesis that a shared biological mechanism of mesenchymal transition, reflected by a precise gene expression signature, may be present in all types of solid cancers when they reach a particular stage of invasiveness
A subset of co-expressed genes in Slug-based cancer mesenchymal transition signature remains coexpressed in normal samples in a tissue-specific manner
No full textA recently identified gene expression signature of EMT markers containing the transcription factor Slug was found present in samples from many publicly available cancer gene expression datasets of multiple cancer types except leukemia. We also found many of these genes co-expressed in human cancer xenografted cells, but not in mouse stroma cells, suggesting that the signature is largely produced by cancer cells undergoing some type of EMT. Here we report that a partial signature consisting of a subset of the co-expressed genes of the full signature, including at least Slug (SNAI2), collagens COL1A1, COL1A2, COL3A1, COL6A3 and genes DCN and LUM, is also present in leukemia, in which case it is also strongly associated with the chemokine CXCL12 (aka SDF1). The same subset of co-expressed genes is also strongly present even in normal samples in a tissue-specific manner, with lowest expression in brain tissues and highest expression in reproductive system tissues. The full signature, with prominent presence of COL11A1, THBS2 and INHBA appears to be triggered in solid cancers particularly when cancer cells encounter adipocytes
3. Anastassiou (A.) et Irmer (D.), Index Hippocraticus
No full textDemont Paul. 3. Anastassiou (A.) et Irmer (D.), Index Hippocraticus. In: Revue des Études Grecques, tome 112, Juillet-décembre 1999. p. 746
35. Kleinere Attische Redner. Ed. A. Anastassiou et D. Irmer. Wege der Forschung
No full textDemont Paul. 35. Kleinere Attische Redner. Ed. A. Anastassiou et D. Irmer. Wege der Forschung. In: Revue des Études Grecques, tome 93, fascicule 440-441, Janvier-juin 1980. p. 291
23. Anastassiou (A), Irmer (D.), Testimonien zum Corpus Hippocraticum, Teil II : Galen, 2. Band : Hippokratteszitate in den übrigen Werken Galens einschliesslich der alten Pseudo-Galenica
No full textBoudon-Millot Véronique. 23. Anastassiou (A), Irmer (D.), Testimonien zum Corpus Hippocraticum, Teil II : Galen, 2. Band : Hippokratteszitate in den übrigen Werken Galens einschliesslich der alten Pseudo-Galenica. In: Revue des Études Grecques, tome 115, Janvier-juin 2002. pp. 441-443
23. Anastassiou (A), Irmer (D.), Testimonien zum Corpus Hippocraticum, Teil II : Galen, 2. Band : Hippokratteszitate in den übrigen Werken Galens einschliesslich der alten Pseudo-Galenica
No full textBoudon-Millot Véronique. 23. Anastassiou (A), Irmer (D.), Testimonien zum Corpus Hippocraticum, Teil II : Galen, 2. Band : Hippokratteszitate in den übrigen Werken Galens einschliesslich der alten Pseudo-Galenica. In: Revue des Études Grecques, tome 115, Janvier-juin 2002. pp. 441-443
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Hippocrate. L'officine du médecin, Texte établi, traduit et commenté par Jacques Jouanna avec la collaboration de Anargyros Anastassiou et Antonio Ricciardetto
No full textpeer reviewedÀ l’intérieur de la Collection hippocratique, le traité intitulé Officine du médecin a pour objet d’exposer ce qui se passe à l’intérieur du cabinet du médecin qui doit opérer un patient dans le cas de blessures, particulièrement de fractures ou de luxations. Pour désigner le cabinet du médecin, on a conservé le mot traditionnel d’« officine », car le cabinet du médecin dans l’Antiquité grecque ne correspond pas exactement à ce que nous entendons actuellement ainsi. La communauté des médecins dans la Grèce antique n’était pas constituée de généralistes et de spécialistes, comme c’était déjà le cas en Égypte ancienne, mais tout médecin devait faire des opérations et avait donc dans son officine les instruments nécessaires pour les réaliser. Cela ne signifie pas que les ouvrages de médecine ne pouvaient pas être spécialisés. Car dans la Collection hippocratique, il y a deux groupes d’ouvrages spécialisés, l’un en gynécologie, l’autre en chirurgie. Le traité de l’Officine du médecin appartient au groupe des cinq grands traités chirurgicaux anciens, les quatre autres étant Fractures, Articulations, Mochlique et Blessures de tête. Ce qui distingue ce traité des autres, c’est qu’il ne décrit pas les différentes blessures, fractures et articulations suivant les différentes parties du corps, mais présente, sous forme soit de mémento soit d’introduction générale, les différents éléments humains ou matériels qui entrent en jeu dans toute opération d’un blessé avant d’en venir dans une seconde partie à une réflexion générale sur ce qui était considéré comme essentiel dans la thérapeutique, à savoir les bandages
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
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