1,720,963 research outputs found
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071388
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071388
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071439
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071570
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071438
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071438
The Effects of 5-Aminolevulinic Acid and Ferrous Iron on Mitochondrial-related Diseases
No full textidentifier:oai:t2r2.star.titech.ac.jp:5071388
Hemin enhances the 5-aminolevulinic acid-photodynamic therapy effect through the changes of cellular iron homeostasis
No full textBackground: Photodynamic therapy (PDT) has been utilized as a promising alternative cancer treatment due to its minimum invasiveness over the years. Exogenous 5-aminolevulinic acid (ALA) triggers protoporphyrin IX (PpIX) accumulation, which happens in cancer cells. However, certain types of cancer exhibit reduced effectiveness in the PpIX accumulation mechanism. This study aimed to determine the effect of ALA-PDT combination with hemin on gastric carcinoma TMK-1 cells. Methods: This study utilized TMK-1 gastric cancer cell line to evaluate PpIX, ROS, and Fe2+ accumulation following the administration of ALA, hemin, and a combination of ALA and hemin PDT. We also evaluate the mRNA expressions related to iron homeostasis and treatment impacts on cell viability. Results: The co-addition of ALA and hemin PDT for 4 h of treatment resulted in a significant decrease in cell viability by up to 18 %. While ALA-PDT enhanced PpIX metabolism, the addition of hemin influenced both the production of reactive oxygen species (ROS) and cellular iron homeostasis by inducing Fe2+ accumulation and affecting mRNA levels of IRP, Tfr1, Ferritin, NFS1, and SDHB. Conclusion: These findings suggest that the addition of ALA and hemin enhances phototoxicity in TMK-1 cells. The combination of ALA and hemin with PDT induces cell death, evidenced by increased cytotoxicity properties such as PpIX and ROS, along with significant changes in TMK-1 gastric cancer iron homeostasis. Therefore, the combination of ALA and hemin could be one of the alternatives in photodynamic therapy for cancer in the future
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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