75 research outputs found
Caricatures de Jules Baric à sujet médical et pharmaceutique
No full textKarikaturen von Jules Baric mit medizinischen und pharmazeutischen Themen.
Der Verfasser macht auf das Interesse des graphischen Werkes von J. J. A. Baric (1825-1905) für die Geschichte der Volks - Medizin und Pharmakopöe aufmerksam. Er hebt acht Karikaturen dieses Künstlers hervor welche den Verkauf in der Apotheke, herkömmliche Heilmittel (Pflaumen gegen Obstipation, Essig gegen Unwohlsein, Süssholz fur die Atmungswege), die Tuberkulose und das Quacksalberthema betreffen.Caricatures by Jules Baric on medical and pharmaceutical subjects.
The author draws attention to the graphic work of J. J. A. Baric (1825-1905) and its interest for history of popular medicine and pharmacopoeie. He presents eight caricatures by this artist, which have to do with selling in the pharmacy, traditional remedies (prunes for constipation, vinegar for fainting, licorice for the respiratory passages), tuberculosis, and the subject of charlatans.Julien Pierre. Caricatures de Jules Baric à sujet médical et pharmaceutique. In: Revue d'histoire de la pharmacie, 73ᵉ année, n°265, 1985. pp. 116-126
Baric Structures on Triangulated Categories and Coherent Sheaves
No full textWe introduce the notion of a baric structure on a triangulated category, as an abstraction of S. Morel\u27s weight truncation formalism for mixed ℓ-adic sheaves. We study these structures on the derived category of G-equivariant coherent sheaves on a G-scheme X. Our main result shows how to endow this derived category with a family of nontrivial baric structures when G acts on X with finitely many orbits.We also describe a general construction for producing a new t-structure on a triangulated category equipped with given t- and baric structures, and we prove that the staggered t-structures on introduced by Achar arise in this way. © The Author(s) 2010. Published by Oxford University Press. All rights reserved. For permissions
Hyper baric carburising process
No full textAnew patented technology improves low pressure carburising in vacuum furnace and traditionalcarburising in sealed quench furnace.The author, starting from argument that is possible to see in the specialized publications on the subject,has examined by scientific criteria which are the limits and the advantages of both the low pressurecarburising ,or the controlled atmosphere process. He evaluates the technological possibility to overcomesome of the limits that are conditioning the mechanical property of the heat treated pieces. Beforesuggesting new technological solutions that can promote better metallurgical properties together withclean environment, he examine some scientific arguments to make clear the problems.At the end of this research some important technological modification will be realised and the obtainedresults confirm the validity of the new process of hyper baric carburisation.The cause of the defects arising from the traditional technology have been eliminated and themodifications requested on the furnaces are not expensive. In same cases, maybe the new furnaces areeven cheaper, both in the buying phase than in the running cost
Usefulness of Unstimulated and Stimulated Whole Saliva, Accuracy of Minor Labial Salivary Gland Biopsy in the Diagnosis of Primary Sjögren's Disease: A Croatian Single-Center, Cross-Sectional Study
No full textThe aim of this cross-sectional study was to determine the accuracy of minor labial salivary gland (MLSG) biopsy in the diagnosis of primary Sjögren' s disease (pSD); to study the correlation between the focus score (FS) and anti-SSA/Ro, anti-SSB/La, anti-SSA and -SSB antibodies, unstimulated whole saliva (UWS) and stimulated whole saliva (SWS); to determine the role of UWS and SWS in the clinical evaluation of pSD patients and patients with sicca symptoms.
Methods. A total of 37 subjects were enrolled in the study and divided into two groups: the test group consisted of 15 patients diagnosed with pSD; the control group consisted of 22 patients who had sicca symptoms but did not meet the 2016 American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) diagnostic criteria. Clinical and laboratory tests, including saliva collection, MLSG biopsy, autoantibody titers, were performed in all patients.
Results. The median of the FS was 1.00 [IQR=1.00-1.50] in the test group, whereas in the control group, it was 0.00 [IQR=0.00-0.00] (p< 0.001). The sensitivity, specificity, and accuracy of MLSG biopsy were 86.7%, 100.0%, and 94.6%, respectively. The results showed a correlation between the FS and antinuclear antibodies (ANA) (p=0.002). In addition, Pearson’s correlation showed a weak negative correlation between UWS (r=-0.058, p=0.73) and SWS (r=-0.022, p=0.90) and the FS. In the test group, 73.3% of patients had abnormal UWS values, while 86.7% had abnormal SWS values; among them, values of 0.00 ml/min for UWS and SWS were found in 60.0% and 26.7% of patients, respectively.
Conclusions. Although MLSG biopsy has great diagnostic value and accuracy in diagnosing pSD, it is not always definitive. Our study found a statistically significant association between the FS and ANA, and the greater utility of SWS in diagnosing pSS
Use of FDG PET to Evaluate Hyperbaric Oxygen Therapy for Bisphosphonate-Related Osteonecrosis of the Jaw
No full textAn 80-year-old man presented with painful swelling in the mandibular region and fistula with pus discharge that developed after tooth extractions. He had taken oral alendronate sodium hydrate and prednisolone for osteoporosis for five years. The lesion was diagnosed as bisphosphonate-related osteonecrosis of the jaw. FDG-PET revealed a high accumulation of FDG in the right mandibular region. The patient underwent hyperbaric oxygen therapy twenty times. FDG-PET SUVmax drastically decreased from 5.6 to 1.8 after hyper baric oxygen therapy, paralleling the change in clinical symptoms, while other modalities did not show remarkable changes. This is the first study demonstrating the utility of FDG-PET in monitoring hyper baric oxygen therapy for bisphosphonate-related osteonecrosis of the jaw
Estudo da estabilidade térmica e bárica da levedura Pichia stipitis
No full textMestrado em Materiais Derivados de Recursos RenováveisO objectivo principal deste trabalho foi a determinação da estabilidade térmica e bárica da levedura P. stipitis. Como objectivo secundário, tentou-se desenvolver um método rápido de quantificação da levedura para facilitar o estudo da estabilidade térmica e bárica. Primeiramente, efectuaram-se rectas de calibração e realizaram-se curvas de crescimento seguindo o crescimento
microbiano por diferentes técnicas experimentais, nomeadamente, a densidade óptica, a contagem por câmara de Neubauer e a contagem por
colónias. Foi possível verificar que é possível quantificar a levedura de modo rápido por contagem em câmara de Neubauer e por densidade óptica. A taxa específica de crescimento obtida foi de 0,4262h-1, com um tempo de duplicação de 1h38min.
O estudo da inactivação térmica foi realizado com temperaturas entre 35,0 ºC e 45,0 ºC e a inactivação bárica com pressões entre 50,0 MPa e 250,0 MPa. À medida que aumenta a temperatura e pressão aumenta a velocidade de destruição da levedura. Os tempos de meia-vida para a inactivação térmica variaram entre 88,67 e 1,04 min e para a incativação bárica entre 4,30 e
0,31min. Para a inactivação térmica foi obtida uma energia de activação de 402899 J/mol, enquanto para a inactivação bárica foi obtido um volume de
activação de -89 cm3/mol.
ABSTRACT: The principal objective of this study was to determine the thermal and baric estabilidity of yeast P. stipitis. As a secondary objective, a development of a rapid method for quantification of the yeast was tried, to facilitate the study of thermal stability and barium. First, calibration line and growth curves was done following the growth of microbial growth by different experimental techniques, including optical density, count by a Neubauer chamber and by colony-forming unit. It was noted that it is possible to quantify the yeast quickly by counting in a
Neubauer chamber and optical density. The specific growth rate obtained was 0,4262, with a doubling time of 1h38min.
The study of thermal inactivation was carried out with temperatures between 35,0ºC and 45,0ºC and the baric inactivation pressures between 50,0
MPa and 250,0 Mpa. As the temperature and pressure increases, the rate of destruction of the yeast increases too. The times of half-life for thermal
inactivation ranged between 88,67 and 1,04 min and for baric inactivation between 4,30 and 0,31 min. An activation energy of 402899 J/mol for the
thermal inactivation was obtained, while for the baric inactivation was obtained a activation volume of -89 cm /mol
Une nuit d’ivresse de novembre 1918 de Miroslav Krleža
No full textLa césure que représentent la fin du régime austro-hongrois et l’avènement immédiat d’une nouvelle dynastie est reflétée dans le texte intitulé Une nuit d’ivresse de novembre 1918, qui s’insère dans le journal de Krleža. Entre œuvre littéraire et réflexion profondément politique, le journal se présente comme un genre hybride, comportant des textes qui font écho au déroulement de la chronologie, mais qui furent rédigés à des dates ultérieures. Une chronologie non linéaire lie ces différents moments, entre l’événement fondateur de novembre 1918 (en tant que jeune auteur cherchant une reconnaissance publique), la phase de mise au point définitive du texte en 1952 (comme de l’un des auteurs majeurs de la Yougoslavie socialiste) et l’élaboration véritable du texte en 1942 (alors qu’il est reclus chez lui et redoute une arrestation). Ces trois moments permettent de saisir l’interprétation que donne Krleža d’une fin d’une guerre qui n’en est pas vraiment une et le rôle que lui-même souhaite s’assigner dans ces événements.The break represented by the collapse of the Austro-Hungarian regime and the immediate advent of a new dynasty is clearly reflected in A Drunken Night in November 1918, a text embedded in Krleža’s diary. Part literary work, part political reflection, the diary is a hybrid text, with elements echoing the unfolding chronology of events, but which were written at later dates. A non-linear chronology links these different moments, which include the foundational month of November 1918 (when Krleža was a young author in search of an audience), the final stage of working on the text in 1952 (after he had become one of the most acclaimed authors in socialist Yugoslavia), and the period when the text was actually elaborated in 1942 (when Krleža was secluded at his home in Zagreb, in fear of being arrested). These three different periods allow us to grasp Krleža’s interpretation of the end of a war that was by no means conclusive, and the role he himself wished to play in the unfolding events
T Cell responses to whole SARS Coronavirus in humans
No full textEffective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping peptides spanning whole SARS-CoV proteome to determine T cell responses from 128 SARS convalescent samples by ex vivo IFN-γ ELISPOT assays. Approximately 50% of convalescent SARS patients were positive for T cell responses, and 90% possessed strongly neutralizing Abs. Fifty-five novel T cell epitopes were identified, with spike protein dominating total T cell responses. CD8+ T cell responses were more frequent and of a greater magnitude than CD4+ T cell responses (p < 0.001).
Polychromatic cytometry analysis indicated that the virus-specific T cells from the severe group tended to be a central memory phenotype (CD27+/CD45RO+) with a significantly higher frequency of polyfunctional CD4+ T cells producing IFN-γ, TNF-α, and IL-2, and CD8+ T cells producing IFN-γ, TNF-α, and CD107a (degranulation), as compared with the mild-moderate group. Strong T cell responses correlated significantly (p < 0.05) with higher neutralizing Ab. The serum cytokine profile during acute infection indicated a significant elevation of innate immune responses. Increased Th2 cytokines were observed in patients with fatal infection. Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation
The integration of dental health education with prenatal education
No full textPLEASE NOTE: This work is protected by copyright. Downloading is restricted to the BU community: please log in with a valid BU account to access and click Download. If you are the author of this work and would like to make it publicly available, please contact [email protected] (M.S.)--Boston University, Henry M. Goldman School of Graduate Dentistry, 1979 (Dental Public Health).Includes bibliographical references (leaves 35-36).The purpose of this project was to assess the type and amount of dental health education currently being offered in the prenatal classes sponsored by the Boston Association for Childbirth Education (BACE), and to develop a dental educational aid for the prenatal educators if a need was found to exist. A survey conducted on BACE educators revealed that the current status of dental education in the prenatal classes was minimal, the instructors' self-assessed dental knowledge was "average", and there was a high interest for including dental information into their future prenatal classes. As a result of these findings, a 40 page dental resource entitled A Dental Handbook for Prenatal Educators was developed. Its use was explained to the prenatal educators during a workshop session. A telephone interview was conducted on the workshop participants two weeks after the workshop. Findings indicated that the Dental Handbook was an excellent educational resource in terms of format, ease of reading and clarity of information, and that the workshop participants' self-assessed level of dental knowledge had unanimously risen to "above average"
Effect of Low Selenium Diet on Glutathione Peroxidase 3 Concentration in Male Sprague-Dawley Rats’ Serum
No full textAim: Determination of antioxidative enzyme glutathione peroxidase 3 (GPx3) serum concentrations after consumption of food which contains different concentrations of selenium (Se).
Research subjects and methods: Four-week-old Sprague Dawley rats consumed food containing different concentrations of Se (food Divan) over a period of 10 weeks. The animals were divided into two groups: 1) normal Se (0.363 mg/kg Se) and 2) low Se (0.030 mg/kg Se). Each animal was weighed at the end of protocol, and serum samples were collected for determining GPx3 concentrations. All experimental procedures were in compliance with the European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes and approved by the Ethics Committee of the Faculty of Medicine in Osijek and the Ministry of Agriculture of the Republic of Croatia.
Results: Different concentrations of Se in food did not cause a change in body weight. Food containing the recommended intake of Se according to the guidelines of the World Health Organization significantly increased GPx3 enzyme concentration (13.96±0.42 mg/ml) when compared to low selective Se (12.04 ± 0.33 mg/ml, p = 0.002).
Conclusion: Serum concentration of the antioxidant enzyme GPx3 depends on the concentration of Se in food. It is shown that, in comparison with food with low Se levels, food containing a normal concentration of Se is enriched with the antioxidant GPx3 which, according to numerous studies, has a protective role in the human body
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