1,720,956 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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Advancing Therapeutic Gene Editing through Development of Novel Delivery Modalities and Gene Editing Strategies
No full textSince the landmark discovery of CRISPR-Cas9 system in 2012, the field of gene editing has rapidly expanded its toolkit. Advances such as base editors (BEs) and prime editors (PEs) now enable precise and permanent DNA modifications. These technologies hold promise not only for correcting a broad spectrum of genetic diseases, but also for innovative applications in common diseases, such as cancer and autoimmune disorders. However, realizing the therapeutic potential of gene editing technologies requires overcoming several key challenges. In this thesis, I describe the development of novel delivery modalities and gene editing strategies to advance the therapeutic applications of CRISPR-based precision gene editing technologies.
In Chapter 1, I review the current state of gene editing technologies, highlighting CRISPR-based precision gene editing tools, existing delivery modalities with a focus on in vivo delivery, and key preclinical and ongoing clinical applications.
In Chapter 2, I describe the development of an engineered virus-like particle (eVLP) system for the in vivo delivery of PE components. PE is a versatile gene editor capable of introducing any base substitution as well as small insertions and deletions, but its large size and complex guide RNA (gRNA) structure pose challenges for efficient delivery. eVLPs represent a promising delivery modality that combine the advantages of viral and non-viral delivery modalities. Through iterative rounds of PE protein and gRNA engineering, along with eVLP construct optimization, we generated PE-eVLPs with substantially improved cargo packaging, thereby enhancing potency. In this chapter, I describe the engineering campaigns that improved the PE-eVLP potency and demonstrate their applications in mouse models for efficient transient delivery of PE cargo in vivo.
In Chapter 3, I describe the development of a gene editing strategy to target prion disease, a fatal and rapidly progressing neurodegenerative disease with no effective treatments. Reducing endogenous prion protein has been proposed as a promising therapeutic hypothesis to delay disease onset or progression. To this end, we developed a base editing approach to permanently install a premature stop codon in the gene encoding prion protein, thereby reducing endogenous prion protein levels. Through delivery of base editing components via adeno-associated virus (AAV), we achieved significant lifespan extension in a mouse model of prion disease. In this chapter, I describe the development of base editing strategy as a potential treatment for prion disease.
In Chapter 4, I describe the progress in developing a base editing strategy to treat Hutchinson-Gilford Progeria Syndrome (hereafter referred to as Progeria). In 2021, our lab reported a base editing strategy delivered by a dual-AAV system that corrected the pathogenic mutation causing Progeria, achieving efficient editing in key tissues such as the heart and descending aorta, and extending lifespan in a mouse model of Progeria. To advance this strategy toward clinical translation, we developed a base editing system that can be delivered with a single AAV, which may improve both in vivo efficacy and manufacturability. In this chapter, I describe the development and characterization of this single-AAV strategy for Progeria.
Finally, in Chapter 5, I conclude by discussing the future directions of each project and the broader outlook for therapeutic gene editing.Chemistry and Chemical Biolog
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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