1,868 research outputs found

    Non-communicable diseases: research priorities to mitigate impact of health system shocks.

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    Amitava Banerjee and colleagues argue that the long term impact of non-communicable diseases should be prioritised in planning the response to and management of future health shock

    Long covid: new wine in need of new bottles

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    Finding solutions to long covid will require new ways of thinking across clinical services and research, says Amitava Banerjee

    A Stacked Segmented Adaptive Power Amplifier in 22nm FD-SOI

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    This work was supported by Soitec. (Corresponding author: Aritra Banerjee.

    sj-pdf-1-jrs-10.1177_01410768231154703 - Supplemental material for Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study

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    Supplemental material, sj-pdf-1-jrs-10.1177_01410768231154703 for Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study by Andrea Dennis, Daniel J Cuthbertson, Dan Wootton, Michael Crooks, Mark Gabbay, Nicole Eichert, Sofia Mouchti, Michele Pansini, Adriana Roca-Fernandez, Helena Thomaides-Brears, Matt Kelly, Matthew Robson, Lyth Hishmeh, Emily Attree, Melissa Heightman, Rajarshi Banerjee and Amitava Banerjee in Journal of the Royal Society of Medicine</p

    Hemingway At War

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    Explores the impact of Hemingway’s war experiences on his journalism and fiction. Drawing on dispatches from By-Line, Banerjee shows how battle imbued Hemingway with a strong aversion to war but a great reverence for the “fighting soldier” whom he considered a tragic hero. Argues that the author’s career as a war correspondent developed his disciplined, unimpassioned writing style and his belief in the inevitability of war and human tragedy

    Author Exchange

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    Anthropologist Mukulika Banerjee and political scientist Sushmita Pati have a conversation about their recently published books set in rural Bengal and Delhi’s urban villages, respectively. They situate their analyses of the intersections between democracy, capitalism, urbanization, and globalization in events, relations, and cultures of the everyday. Their exchange offers important insights for how political subjectivities and social ties are differently constituted or, to use Banerjee’s term, “cultivated” in these two settings. The two books offer a fine-grained view of how active citizenship in rural and urban India is refracted through distinct social and institutional structures. India is home to some of the world’s largest cities while more than 900 million people continue to live in the countryside. Its democratic future is therefore inextricably tied to the evolution of political behavior and political economy in both contexts, and, as Banerjee and Pati’s joint response indicates, to how urban and rural dynamics shape each other through (but not only through) migrants and their networks. Contents: Review of Mukulika Banerjee’s \u27Cultivating Democracy: Politics and Citizenship in Agrarian India\u27 by Sushmita Pati Response from Mukulika Banerjee Review of Sushmita Pati’s \u27Properties of Rent: Community, Capital and Politics in Globalising Delhi\u27 by Mukulika Banerjee Response from Sushmita Pati Joint Commentary from Banerjee and Pat

    Optimisation of oral anticoagulation for stroke prevention: a scoping review of factors influencing uptake and implementation in effectiveness studies

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    ePoster abstract and 2 minute audio recording, as presented at UK Stroke Forum 2021 (UKSF2021); Presenter: Jo C. Weldon, Preston, United Kingdom; Authors: Josephine M. Gibson, Preston, United Kingdom; Jo C. Weldon, Preston, United Kingdom; Amitava Banerjee, London, United Kingdom; Umesh Chauhan, Preston, United Kingdom; Rachel Georgiou, Preston, United Kingdom; Miland Joshi, Preston, United Kingdom; Deirdre Lane, Liverpool, United Kingdom; Deborah Lowe, London, United Kingdom; Naoimh McMahon, Lancaster, United Kingdom; Paul Rutter, Portsmouth, United Kingdom; Cheng-Hok Toh, Liverpool, United Kingdom; Dame Caroline L. Watkins, Preston, United Kingdom

    Dinuclear cobalt(II) complexes of Schiff-base compartmental ligands: Syntheses, crystal structure and bio-relevant catalytic activities

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    Three dicobalt(II) complexes, namely [Co2(L1H)(H2O)2(OAc)2](OAc)2 (1), [Co2(L2)(H2O)2(OAc)2](OAc) (2) and [Co2(L3)(H2O)2(OAc)2](OAc) (3) of the p-cresol based ‘‘end-off’’ compartmental ligands 2,6-bis(R-iminomethyl)- 4-methyl-phenolato, where R = N-ethylpiperazine for L1, 2-ethylpyridine for L2 and N-ethylpiperidine for L3, have been synthesized and characterized by common physicochemical techniques, and in the case of complex 1 also by single crystal X-ray diffraction analysis. All the complexes show excellent catecholase-like activity, monitored not only with 3,5-di-tert-butylcatechol but also with tetrachlorocatechol, a substrate reluctant to be oxidized. To the best of our knowledge, to date no cobalt complex has been found in the literature to manifest such activity. The complexes are observed to interact efficiently with CT-DNA and on incubation (employing plasmid pTZ57/R/T DNA) they exhibit concentration dependent DNA cleavage activity. The mechanisms related to the DNA cleavage and catecholase-like activities have been investigated. The cytotoxicity of the complexes has also been examined through an MTT assay

    Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania

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    Leishmaniasis, a vector-borne disease, is caused by intracellular parasite Leishmania donovani. Unlike most intracellular pathogens, Leishmania donovani are lodged in parasitophorous vacuoles and replicate within the phagolysosomes in macrophages. Effective vaccines against this disease are still under development, while the efficacy of the available drugs is being questioned owing to the toxicity for nonspecific distribution in human physiology and the reported drug-resistance developed by Leishmania donovani. Thus, a stimuli-responsive nanocarrier that allows specific localization and release of the drug in the lysosome has been highly sought after for addressing two crucial issues, lower drug toxicity and a higher drug efficacy. We report here a unique lysosome targeting polymeric nanocapsules, formed via inverse mini-emulsion technique, for stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line. A benign polymeric backbone, with a disulfide bonding susceptible to an oxidative cleavage, is utilized for the organelle-specific release of miltefosine. Oxidative rupture of the disulfide bond is induced by intracellular glutathione (GSH) as an endogenous stimulus. Such a stimuli-responsive release of the drug miltefosine in the lysosome of macrophage RAW 264.7 cell line over a few hours helped in achieving an improved drug efficacy by 200 times as compared to pure miltefosine. Such a drug formulation could contribute to a new line of treatment for leishmaniasis.A. Das acknowledges SERB (India) Grants (CRG/2020/000492 and JCB/2017/000004) and DBT Grant (BT/PR22251/NNT/28/1274/2017) for supporting this research. N. Mukherjee acknowledges SERB (India) Grant PDF/2016/001437 and K. Das acknowledges the grant EMR/2015/001674 for supporting this research. Financial support from DST (DST/INSPIRE/03/2017/002477) is acknowledged by R.T. This manuscript bears CSMCRI registration no 7/2021.Pramanik, SK (corresponding author), CSIR Cent Salt & Marine Chem Res Inst, Bhavnagar 364002, Gujarat, India. Mukherjee, N (corresponding author), CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, Kolkata 700032, India. Chattopadhy, S (corresponding author), BITS Pilani, Pilani 403726, Goa, India. Das, A (corresponding author), Indian Inst Sci Educ & Res Kolkata, Mohanpur 741246, W Bengal, India. [email protected]; [email protected]; [email protected]

    Banerjee_QSurvey_RawDataSet_PPC

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    Raw dataset for questionnaire survey study (kinesiology taping_cancer care continuum)Author: Gourav Banerjee et alJournal: Progress in Palliative Care</div
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