1,723,235 research outputs found
ADAMS/FlexPTCV
No full textADAMS/FlexPTCV è una utilità di modellazione sviluppata e validata assieme all’Ing. Francesco Ambrogi che consente di simulare. il moto di generiche parti o sottosistemi su componenti flessibili utilizzando una metodologia basata su logiche CAD ed approccio modale del comportamento del corpo flessibile. Questo tool è disponibile come strumento accessorio nel codice ADAMS/Vie
Immunomodulators and enzymes of purine metabolism in human lymphocytes. Ambrogi F, Petrini M, Azzara A, Carulli G, Caracciolo F, Grassi B, Bertelli A.
No full textThe enzymes ADA and PNP were evaluated in lymphocytic subpopulations in peripheral blood obtained from healthy subjects, elderly subjects and patients with immunoproliferative diseases. Some similar assessments were performed on lymphoid cells from cord blood. Preliminary studies indicate that Thymostimulin can in some cases correct enzymic defects
Steering system tuning through virtual analysis: parameter identification and target setting of electrical power steering
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Evidenza clinica e sperimentale dell'attivita' antimitotica della bromocriptina (CB-154).
No full textLeukocyte migration inhibitory activity in the serum of patients affected by Hodgkin's disease and other immunoproliferative diseases
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TP53 mutation, epithelial-mesenchymal transition, and stemlike features in breast cancer subtypes
No full textAltered p53 protein is prevalently associated with the pathologic class of triple-negative breast cancers and loss of p53 function has recently been linked to the induction of an epithelial-mesenchymal transition (EMT) and acquisition of stemness properties. We explored the association between TP53 mutational status and expression of some genes involved in the canonical TGF- signaling pathway (the most potent EMT inducer) and in two early EMT associated events: loss of cell polarity and acquisition of stemness-associated features. We used a publicly accessible microarray dataset consisting of 251 p53-sequenced primary breast cancers. Statistical analysis indicated that mutant p53 tumors (especially those harboring a severe mutation) were consistent with the aggressive class of triple-negative cancers and that, differently from cell cultures, surgical tumors underexpressed some TGF-β related transcription factors known as involved in EMT (ID1, ID4, SMAD3, SMAD4, SMAD5, ZEB1). These unexpected findings suggest an interesting relationship between p53 mutation, mammary cell dedifferentiation, and the concomitant acquisition of stemlike properties (as indicated by the overexpression of PROM1 and NOTCH1 genes), which improve tumor cells aggressiveness as indicated by the overexpression of genes associated with cell proliferation (CDK4, CDK6, MKI67) and migration (CXCR4, MMP1). © Copyright 2012 Danila Coradini et al
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