90 research outputs found
Correction to: The hidden therapist: evidence for a central role of music in psychedelic therapy.
No full textThe article The hidden therapist: evidence for a central role of music in psychedelic therapy, written by Mendel Kaelen, Bruna Giribaldi, Jordan Raine, Lisa Evans, Christopher Timmerman, Natalie Rodriguez, Leor Roseman, Amanda Feilding, David Nutt, Robin Carhart-Harris, was originally published electronically on the publisher's internet portal
Supplementary_Material_841568 – Supplemental material for Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity
No full textSupplemental material, Supplementary_Material_841568 for Dissociable effects of cannabis with and without cannabidiol on the human brain’s resting-state functional connectivity by Matthew B Wall, Rebecca Pope, Tom P Freeman, Oliwia S Kowalczyk, Lysia Demetriou, Claire Mokrysz, Chandni Hindocha, Will Lawn, Michael AP Bloomfield, Abigail M Freeman, Amanda Feilding, David J Nutt and H Valerie Curran in Journal of Psychopharmacology</p
sj-docx-1-jop-10.1177_02698811211069113 – Supplemental material for LSD and creativity: Increased novelty and symbolic thinking, decreased utility and convergent thinking
No full textSupplemental material, sj-docx-1-jop-10.1177_02698811211069113 for LSD and creativity: Increased novelty and symbolic thinking, decreased utility and convergent thinking by Isabel Wießner, Marcelo Falchi, Lucas Oliveira Maia, Dimitri Daldegan-Bueno, Fernanda Palhano-Fontes, Natasha L Mason, Johannes G Ramaekers, Madeleine E Gross, Jonathan W Schooler, Amanda Feilding, Sidarta Ribeiro, Draulio B Araujo and Luís Fernando Tófoli in Journal of Psychopharmacology</p
Blood and Desire
No full textIn 1970 Amanda Feilding drilled a hole in her head to access a blissful state. These actions were captured in her multi-media artwork, Trepanation for the National Health (1978). Meanwhile, Penny Slinger sought ecstatic liberation through self-exorcism. This resulted in her feminist surrealist, sexually transgressive, autobiographical photo-collage series, An Exorcism (1969–77). Challenging the male-centric histories of the British counterculture, this chapter maps Slinger and Feilding’s fearless female experimentation and the tightly interwoven series of lover-collaborators led by their radical image making. It argues that these experiments facilitated ground-breaking representations of alternative states of being, gender, sexuality, and arousal
Daring to regulate coca and cocaine: Lessons from Colombia's drug war trenches
No full textThis essay is from a Beckley Foundation Report, commissioned and convened by Amanda Feilding for the Beckley Foundation¿s Global Initiative for Drug Policy Reform, called The Cocaine Papers. This Report is the latest in the Beckley Foundation's "Roadmaps to Regulation" series, and will be published later this year. It is a critical review of Colombia¿s 2020 legislative proposal (law project 236) to regulate the coca leaf and cocaine markets, authored by Senator Iván Marulanda and co-sponsored with Senator Feliciano Valencia. The essay provides a qualitative analysis of the regulatory regime proposed, its effects across the supply system, and the associated benefit and cost outcomes for Colombia. The essay concludes with a reflection on the challenges surrounding the adoption of coca leaf and cocaine regulation and offers lessons to overcome the political barriers to policy chang
Interview with Amanda Feilding, Lady Neidpath, Founder and Director of the Beckley Foundation
No full textCortical correlates of psychedelic-induced shaking behavior revealed by voltage imaging
No full text(1) From mouse to man, shaking behavior (head twitches and/or wet dog shakes) is a reliable readout of psychedelic drug action. Shaking behavior like psychedelia is thought to be mediated by serotonin 2A receptors on cortical pyramidal cells. The involvement of pyramidal cells in psychedelic-induced shaking behavior remains hypothetical, though, as experimental in vivo evidence is limited. (2) Here, we use cell type-specific voltage imaging in awake mice to address this issue. We intersectionally express the genetically encoded voltage indicator VSFP Butterfly 1.2 in layer 2/3 pyramidal neurons. We simultaneously capture cortical hemodynamics and cell type-specific voltage activity while mice display psychedelic shaking behavior. (3) Shaking behavior is preceded by high-frequency oscillations and overlaps with low-frequency oscillations in the motor cortex. Oscillations spectrally mirror the rhythmics of shaking behavior and reflect layer 2/3 pyramidal cell activity complemented by hemodynamics. (4) Our results reveal a clear cortical fingerprint of serotonin-2A-receptor-mediated shaking behavior and open a promising methodological avenue relating a cross-mammalian psychedelic effect to cell-type specific brain dynamics
The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner.
No full textBACKGROUND: Serotonin 2A receptors, the molecular target of psychedelics, are expressed by neuronal and vascular cells, both of which might contribute to brain haemodynamic characteristics for the psychedelic state. AIM: Aiming for a systemic understanding of psychedelic vasoactivity, here we investigated the effect of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine - a new-generation agonist with superior serotonin 2A receptor selectivity - on brain-supplying neck-arterial blood flow. METHODS: We recorded core body temperature and employed non-invasive, collar-sensor based pulse oximetry in anesthetised mice to extract parameters of local blood perfusion, oxygen saturation, heart and respiration rate. Hypothesising an overlap between serotonergic pulse- and thermoregulation, recordings were done under physiological and elevated pad temperatures. RESULTS: N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (1.5 mg/kg, subcutaneous) significantly increased the frequency of heart beats accompanied by a slight elevation of neck-arterial blood flow. Increasing the animal-supporting heat-pad temperature from 37°C to 41°C enhanced the drug's effect on blood flow while counteracting tachycardia. Additionally, N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine promoted bradypnea, which, like tachycardia, quickly reversed at the elevated pad temperature. The interrelatedness of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine's respiro-cardiovascular effects and thermoregulation was further corroborated by the drug selectively increasing the core body temperature at the elevated pad temperature. Arterial oxygen saturation was not affected by N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine at either temperature. CONCLUSIONS: Our findings imply that selective serotonin 2A receptor activation modulates systemic cardiovascular functioning in orchestration with thermoregulation and with immediate relevance to brain-imminent neck (most likely carotid) arteries. As carotid branching is a critical last hub to channel cardiovascular output to or away from the brain, our results might have implications for the brain haemodynamics associated with psychedelia
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