126,168 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Development in building activity, materials and techniques of the Early to Middle Cyprus Architecture
No full textTobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1 : role of prostacyclin and NADPH-oxidase
No full textTobacco smoke (TS) interacts with interleukin-1β (IL-1β) to modulate generation of reactive oxygen species (ROS) and expression of cyclooxygenase-2. We explored molecular mechanisms by which TS/IL-1β alters expression and activity of microsomal-prostaglandin E synthase-1 (mPGES-1) and of prostacyclin synthase (PGIS) in mouse cardiac endothelial cells. TS (EC(50) ∼5 puffs/L) interacting with IL-1β (2 μg/L) up-regulates PGE(2) production and mPGES-1 expression, reaching a plateau at 4-6 h, but down-regulates prostacyclin (PGI(2)) release by increasing IL-1β-mediated PGIS tyrosine nitration. Inhibition of NADPH-oxidase, achieved pharmacologically and/or by silencing its catalytic subunit p47phox, or exogenous PGI(2) (carbaprostacyclin; IC(50) ∼5 μM) prevents production of both ROS and PGE(2), and negatively modulates mPGES-1 expression induced by TS/IL-1β. Moreover, inhibiting PGI(2), either using PGIS siRNA and/or CAY10441 (EC(50) ∼20 nM), a PGI(2) receptor antagonist, increases NADPH-oxidase activation, mPGES-1 synthesis, and PGE(2) production. Finally, lower PGI(2) levels associated with higher PGIS tyrosine nitration, p47phox translocation to the membrane (an index of activation of NADPH-oxidase), and mPGES-1 expression and activity were detected in cardiovascular tissues of ApoE(-/-) mice exposed to cigarette smoke compared to control mice. In conclusion, cigarette smoke in association with cytokines alters the balance between PGI(2)/PGE(2), reducing PGI(2) production and increasing synthesis and activity of mPGES-1 via NADPH-oxidase activation, predisposing to development of pathological conditions.-Barbieri, S. S., Amadio, P., Gianellini, S., Zacchi, E., Weksler, B. B., Tremoli, E. Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase
Synthesis of Water-soluble Triazole Ligands and Application of Their Metal Complexes in Biphasic Hydrogenations of C=C and C=O
No full textAbstract:
Homogenous catalysis is a powerful tool for organic synthesis but its success in industrial application is limited because of difficult catalyst separation and reuse. To overcome these issues, the use of biphasic catalysis is at present of great interest because the catalyst is confined in one of the two-phases and the product in the other phase allowing for a prompt recovery of the product and an easy recycle of the catalyst. In particular, the development of water soluble catalysts for aqueous/organic biphasic reactions is increasingly attractive [1]. Our research group has been involved in the synthesis of triazolyl ligands by taking advantage of the copper-catalyzed azide-alkyne [3+2] cyclization [2]. Recently, we have synthesized a small library of N-N or N-S ligands which have been employed in Suzuki-Miyaura reactions [3,4]. In this work, we wish to present our studies on biphasic (water/toluene) catalytic hydrogenation of C=O and C=C (Schemes 3 & 4) double bonds using a water soluble triazole ligand in combination with Ruthenium and Iridium.
[1] (a) Cornils B.; Herrmann W. A.; Horvath I. T.; Leitner W.; Mecking S.; Olivier-Bourbigou H.; Vogt (Eds.) D. Multiphase Homogeneous Catalysis, Wiley-VCH, Weinheim, 2005. (b) Joo F. Aqueous Organometallic Catalysis, Kluwer Acad. Publ. Dordrecht, 2001. [2] V. V. Rostovtsev, L.G. Green, V.V. Fokin, K.B. Sharpless, Angew. Chem., Int. Ed. 2002, 41, 2596. [3] Amadio E.; Scrivanti A.; Chessa G.; Matteoli U.; Beghetto V.; Bertoldini M.; Rancan M.; Venzo A.; Bertani R. J. Org. Chem. 2012, 716, 193. [4] Amadio E.; Bertoldini M.; Scrivanti A.; Chessa G.; Beghetto V.; Matteoli U.; Bertani R.; Dolmella A. Inorg. Chim. Acta 2011, 370, 388
Adjuvant electrochemotherapy with bleomycin and cisplatin combination for canine soft tissue sarcomas: a study of 30 cases
No full textElectrochemotherapy (ECT) couples the administration of anticancer drugs with the delivery of electric pulses that increase the drug uptake through the cell membranes, thus resulting in an improved efficacy. This study has evaluated the tolerability and efficacy of the combination of systemic bleomycin and local cisplatin as ECT agents for incompletely excised canine soft tissue sarcoma (STS). Thirty dogs with incompletely excised STSs were enrolled. The dogs received intravenous 20 mg/m2 bleomycin and the tumor bed and margins were infiltrated with cisplatin at the dose of 0.5 mg/cm2. Then, trains of permeabilizing biphasic electric pulses were applied under sedation. More precisely, five minutes after the injection of the chemotherapy agents, sequences of 8 biphasic pulses lasting 50+50 microseconds each, were delivered in bursts of 1300 V/cm using caliper electrodes. A second session was performed two weeks later. The treatment was well tolerated and side effects were minimal. Twenty-six dogs had no evidence of recurrence at the time of manuscript writing, four had recurrence and one of the four recurring dogs, died of lung metastases. Median estimated disease free was 857 days. Perivascular wall tumors response was compared to that of the other STSs, but the difference in outcome was not significative. ECT using combination of bleomycin and cisplatin appears to be effective in the treatment of incompletely resected STSs in dogs. This therapeutic approach could be a useful addition to the current options in consideration of its low cost, limited toxicity, and ease of administration
Lettere d'uomini illustri conservate in Parma nel R. Archivio dello stato. Volume I.°
No full textNo more published.Dedication signed: Amadio Ronchini.Alamanni, L.--Anguillara (dell') G.A.--Bandello, M.--Bartoli, C.--Bembo, P.--Bonfadio, J.--Caro, A.--Cada (della) G.--Guarini, B.--Giucciardini, F.--Molza, F.M.--Salviati, L.--Tansillo, L.--Tasso, B.--Tasso, T.--Tolomei, C.--Trissino, G.G.--Vettori, P.Mode of access: Internet
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Mapping P2X and P2Y receptor proteins in striatum and substantia nigra: An immunohistological study.
No full textAnalysis of the stress and deformation states in the vertical flat-jack test
No full textPerforming a realistic assessment of unreinforced masonry structures involves designing and executing appropriate experimental tests on masonry components for determining the material model parameters to be used in structural analysis. Considering recent developments in which inverse analysis was used as calibration framework, a vertical flat-jack test is investigated in this paper. Two simplified models are described for the analysis of the stress state in the masonry due to the pressure transferred by the flat-jack. Furthermore, with the aim of designing the sensor setup for the test, a POD analysis on the deformation state of the structure is carried out, highlighting the basic deformation modes which govern the response. The results show that high stresses and local modes can occur in the proximity of the flat-jack, and thus local use of FRP reinforcement is recommended to avoid undesired brittle crack propagation which may prevent accurate calibration of mortar joint mechanical characteristics
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