140,655 research outputs found
Defensa de Aulo Cecina
No full textTexto en latín e españolPrecede ó tit : Consejo Superior de Investigaciones Científicas Instituto "Antonio de Nebrija
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
New insights on the molecular and cell biology of human cholangiopathies.
No full textMol Aspects Med. 2008 Feb-Apr;29(1-2):50-7. Epub 2007 Oct 24.
New insights on the molecular and cell biology of human cholangiopathies.
Alvaro D, Mancino MG.
SourceDivision of Gastroenterology, Department of Clinical Medicine, Rome, Italy.
Abstract
Cholangiopathies are diseases of high social impact representing the main indication for liver transplantation in the infanthood and the third in adulthood. Despite the heterogeneous etiology and pathogenesis, cholangiopathies share many different common morphological features and, chronically progress toward a ductupenic condition clinically evidenced by the classical features of a cholestatic syndrome. The primary target of damage in the course of cholangiopathies are cholangiocytes, the epithelia cells lining the biliary tree. A bulk of researches performed in the last decade, highlighted the extraordinary biological properties of cholangiocytes involved in a number of important processes such as bile formation, proliferation, injury repair, fibrosis, angiogenesis and regulation of blood flow. Recent advances on the molecular and cell biology of human cholangiopathies are opening new potential therapeutic perspectives for these diseases.
PMID: 18230407 [PubMed - indexed for MEDLINE
Cholangiocarcinoma: risk factors and clinical presentation.
No full textEur Rev Med Pharmacol Sci. 2010 Apr;14(4):363-7.
Cholangiocarcinoma: risk factors and clinical presentation.
Gatto M, Alvaro D.
SourceDepartment of Clinical Medicine, Division of Gastroenterology, "Sapienza" University of Rome, Polo Pontino, Rome, Italy.
Abstract
Cholangiocarcinoma (CCA), a cancer originating from the neoplastic transformation of the biliary epithelium, is characterized by a progressive increase in incidence and prevalence. A number of risk factors have been identified including primary sclerosing cholangitis, liver fluke infestation, and hepatolithiasis. More recently, hepatitis viruses (HCV, HBV) have been taken into consideration as risk factors for the intrahepatic CCA and this could explain the increased incidence seen in the last two decades. All these risk factors induce chronic inflammation in the biliary epithelium together with partial bile obstruction. These two conditions are considered the background (chronic inflammation) favouring the cancer development. The only effective treatment is the radical surgical resection but, this is applicable in less than 40% of the patients since CCA is mostly diagnosed at an advanced stage. This mainly occurs because, in the majority of the cases, CCA is clinically silent, with symptoms only developing at an advanced stage but also for the lack of effective biomarkers to be used for a screening purpose. A number of serum and bile biomarkers have been recently proposed for the diagnosis of CCA but, their impact on the early diagnosis is still under the evaluatio
Métricas de autor Alvaro Hernan Moreno Durán
No full textInforme de las métricas de autor del Dr. Alvaro Hernan Moreno Durán de las publicaciones indexadas en Google Académico cuyo objetivo es entregar un insumo para el fortalecimiento de las capacidades y potencialidades de los autores de la Universidad Santo Tomás en el posicionamiento y visibilidad de sus publicaciones.Report of the author metrics Alvaro Hernan Moreno Durán of the publications indexed in Google Scholar whose objective is to provide an input for the strengthening of the capacities and potentialities of the authors of the Santo Tomás University in the positioning and visibility of their publications.http://unidadinvestigacion.usta.edu.c
DISCURSOS DE LA CAMPAÑA DEL GRAL. ALVARO OBREGON
No full textSpeech given by the Governor of Arizona, Thomas E. Campbell, during the dinner hosted by both Chambers of Commerce in Nogales, to Gen. Alvaro Obregón, emphasizing the fact that for a long time there has not been a mutual understanding between Mexico and the United States and that this can be attributed to the fact that their nationals do not thoroughly know each other; he highlights Gen. Alvaro Obregón as the leader who will advance Mexico and offers his friendship to both the people of Mexico and their newly elected leadership. An introductory commentary from Gen. Obregón and a speech by Mr. Flavio A. Bórquez, Governor of Sonora, excusing himself for not being a great orator, thanking for the friendship of Governor Campbell and offering to work to extend relationships between both countries. Invitation to a banquet in honor of Gen. Alvaro Obregón. Files D-07, D-08, and D-09. / Discurso pronunciado por el Gobernador de Arizona, Thomas E. Campbell, durante la comida que le ofrecieron las Cámaras de Comercio de ambos Nogales al Gral. Alvaro Obregón, enfatizando el hecho de que es ya demasiado largo el tiempo que ha transcurrido sin un buen entendimiento entre México y Estados Unidos y que ello debe atribuirse a que sus nacionales no se conocen a fondo; destaca la figura del Gral. Alvaro Obregón como la del líder que hará progresar a México y ofrece su amistad tanto al pueblo de México como a sus nuevos gobernantes. Un comentario introductorio del Gral. Alvaro Obregón y un discurso del Sr. Flavio A. Bórquez, Gobernador del estado de Sonora, excusándose por no ser orador, agradece la amistad del Gobernador Campbell y ofrece trabajar para estrechar las relaciones entre ambos países. Invitación a un banquete en honor del Gral. Alvaro Obregón. Exps. D-07, D-08 y D-0
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Implications for transportation planning of changing production and distribution processes
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 1997.Includes bibliographical references (p. 232-241).by Alvaro E. Pereira.Ph.D
Improvement of estradiol 17 beta-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the rat
No full textThe intravenous administration of dimethylethanolamine in the rat promotes a selective enrichment of liver membranes with polyunsaturated phosphatidylcholines. The effect of dimethylethanolamine pretreatment on cholestasis induced by estradiol 17 beta-D-glucuronide, a potent cholestatic agent, was assessed in this study. Dimethylethanolamine, dissolved in sodium-taurocholate was infused intravenously (0.3 mg/kg/min) for 15 hr. One group of control rats (estradiol 17 beta-D-glucuronide controls) received the bile salt only. An estradiol 17 beta-D-glucuronide bolus was then injected intravenously (10.4 mg/kg) into dimethylethanolamine-pretreated and estradiol 17 beta-D-control rats, and its effect on bile flow and biliary lipid secretion was compared for 3 hr. The estradiol 17 beta-D-glucuronide inhibitory effect on bile flow and biliary lipid secretion was significantly antagonized by dimethylethanolamine pretreatment. The maximum inhibition of bile flow was found 30 min after estradiol 17 beta-D-glucuronide administration, when it decreased from 3.5 +/- 0.4 microliters/min/100 gm (basal) to 0.9 +/- 0.3 microliters/min/100 gm in estradiol 17 beta-D-glucuronide controls, whereas in dimethylethanolamine-pretreated rats this decreased only from 3.2 +/- 0.4 (basal) to 2.3 +/- 0.4 microliters/min/100 gm. Bile flow and the biliary secretion of cholesterol, phosphatidylcholine and bile salts were significantly higher in the dimethylethanolamine-pretreated rats than in estradiol 17 beta-D-glucuronide controls (p less than 0.02) during the cholestatic phase. The inhibitory effect of estradiol 17 beta-D-glucuronide on bile flow was associated with a marked decrease of membrane fluidity (p less than 0.001) assessed by 1,6-diphenyl-1,3,5-hexatriene fluorescence anisotropy and with a cholesterol enrichment of microsomes, sinusoidal and canalicular liver plasma membranes and inhibition of sinusoidal Na+,K(+)-ATPase activity (p less than 0.05). These membrane alterations persisted 180 min after estradiol 17 beta-D-glucuronide administration despite complete normalization of bile flow. Dimethylethanolamine pretreatment significantly counteracted the reduction of membrane fluidity (p less than 0.001), the cholesterol enrichment and the inhibition of Na+,K(+)-ATPase (p less than 0.05) promoted by estradiol 17 beta-D-glucuronide administration in all membrane subfractions 30 and 180 min after administration. In addition, dimethylethanolamine-pretreated rats had more polyunsaturated fatty acids in membrane phosphatidylcholine with respect to the control groups. Dilatation of canaliculi and loss of microvilli were evident in estradiol 17 beta-D-glucuronide controls 180 min after estradiol 17 beta-D-glucuronide administration.(ABSTRACT TRUNCATED AT 400 WORDS
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