9,330 research outputs found
Distribution of Y chromosomal STRs loci in Mayan and Mestizo populations from Guatemala
No full textIn this study, a sample of 225 Guatemalan males, comprising 115 Mestizo-Guatemalan and 110 Mayan-Guatemalan, was typed for 17 Y-short tandem repeats (STRs) loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635, YGATA_H4.1 and DYS385a/b). The haplotype diversity (H = 1) and discrimination capacity (96.86%) were calculated. Analysis of molecular variance (AMOVA) demonstrated a low but significant interpopulation differentiation when compared with the results obtained when we confront the Mestizo and Mayanpopulations with the European populations.
Furthermore, the genetic variability and differences among the American, African, Asian, and European populations were analyzed with the software Statistica 9.1. In addition, the genetic distances were also calculated using other published data. Reynolds and Slatkińs genetic distance was visualized using the multidimensional scaling (MDS) analysis. All the analysis performed locates the Mayanpopulation next to the Native American population, while Guatemalan-Mestizopopulation was found to be between these populations and the European population, similar to other Mestizo one.
The implementation of the estimation of individual ancestry proportions of the whole population sample showed the presence of two well-differentiated population groups
Genotype data for 38 INDELs of 143 unrelated adults from the SouthEast Spanish population
No full textData from the paper:Population genetic data of 38 insertion-deletion markers in South East Spanish population. M Saiz, MJ Alvarez-Cubero, LJ Martinez-Gonzalez, JC Alvarez, JA Lorente.Forensic Science International: Genetics (2014), 13; 236-
Genotype data for 38 INDELs of 143 unrelated adults from the SouthEast Spanish population
No full textData from the paper:Population genetic data of 38 insertion-deletion markers in South East Spanish population. M Saiz, MJ Alvarez-Cubero, LJ Martinez-Gonzalez, JC Alvarez, JA Lorente.Forensic Science International: Genetics (2014), 13; 236-8THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV
Characteristics of Q-switched cladding-pumped ytterbium-doped fiber lasers with different high-energy fiber designs
No full textWe theoretically and experimentally analyze Q-switched cladding pumped ytterbium-doped fiber lasers designed for high pulse energies. We compare the extractable energy from two high-energy fiber designs: (1) single- or few-moded low-NA large mode area (LMA) fibers and (2) large-core multimode fibers, which may incorporate a fiber taper for brightness enhancement. Our results show that the pulse energy is proportional to the effective core area and, therefore, LMA fibers and multimode fibers of comparable core size give comparable results. However, the energy storage in multimode fibers is mostly limited by strong losses due to amplified spontaneous emission (ASE) or even spurious lasing between pulses. The ASE power increases with the number of modes in a fiber. Furthermore, spurious feedback is more difficult to suppress with a higher NA, and Rayleigh back-scattering increases with higher NA, too. These effects are smaller in low-NA LMA fibers, allowing for somewhat higher energy storage. For the LMA fibers, we found that facet damage was a more severe restriction than ASE losses or spurious lasing. With a modified laser cavity, we could avoid facet damage in the LMA fiber, and reached output pulse energies as high as 2.3 mJ, limited by ASE. Theoretical estimates suggest that output pulse energies around 10 mJ are feasible with a larger core fiber, while maintaining a good beam qualit
Multi-mJ, multi-Watt Q-switched fiber laser
No full textUsing a large mode area, ytterbium-doped cladding-pumped fiber and a novel cavity configuration we obtain 2.3 mJ Q-switched pulses, a record pulse energy for a fiber laser. Average powers in excess of 5W were achieved
Prognostic role of genetic biomarkers in clinical progression of prostate cancer.
No full textJournal Article;The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as well as perform a genetic classification of high-risk patients. A cohort of 451 men (235 patients and 216 controls) was studied. We calculated means of regression analysis using clinical values (stage, prostate-specific antigen, Gleason score and progression) in patients and controls at the basal stage and after a follow-up of 72 months. Significantly different allele frequencies between patients and controls were observed for rs1904577 and rs918 (MSR1 gene) and for rs17552022 and rs5030739 (ELAC2). We found evidence of increased risk for PCa in rs486907 and rs2127565 in variants AA and CC, respectively. In addition, rs627928 (TT-GT), rs486907 (AG) and rs3747531 (CG-CC) were associated with low tumor aggressiveness. Some had a weak linkage, such as rs1904577 and rs2127565, rs4792311 and rs17552022, and rs1904577 and rs918. Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa. In the future, clinical use of these biomarkers, in combination with current ones, could potentially reduce the rate of unnecessary biopsies and specific treatments.Ye
SYNTHETIC CANNABINOIDS AND THE SEROTONIN SYNDROME: AN UNFORESEEN ASSOCIATION
No full textSYNTHETIC CANNABINOIDS AND THE SEROTONIN SYNDROME: AN UNFORESEEN ASSOCIATION Duccio Papanti 1, Laura Orsolini 2, Tommaso Bonavigo 1, Federico Sandri 1, Elisabetta Pascolo-Fabrici 1, Fabrizio Schifano 3 1 University of Trieste, Italia 2 University of Marche, Italia 3 University of Hertfordshire, UK Educational Objectives: Use of synthetic cannabinoids (SCs) has been increasingly associated with severe adverse effects, including deaths. SC intoxication is very different to cannabis one and shows common features with the serotonin syndrome. Purpose Synthetic cannabinoid compounds belong to a new psychoactive class of substances misused as an alternative to marijuana (MJ). These compounds have been developed for research purposes and have never been tested in clinical human studies. Currently, SCs can be easily bought on a global level, both online and in local stores. We aimed here at identifying SC pharmacodynamics, effects/symptoms of intoxication and neurobehavioral sequaelae in humans, with a focus on findings compatible/common to the serotonin syndrome. Methods: A search was carried out on PubMed/Medline for the terms “synthetic cannabimimetics”, “synthetic cannabinoids”, “synthetic cannabis” in order to identify effects/symptoms of intoxication, neurobehavioral sequaelae related to SC intake in humans. Results: SC compounds are structurally dissimilar and incorporate indole mojeties, not present in MJ. SC are full agonists on cannabinoid receptors (CB-rs) while cannabis main psychoactive, tetrahydrocannabinol (THC), exerts partial agonism on cannabinoid receptors. SCs visual hallucinations are described as fractals/trails/flashes of colour/geometric patterns [1]. Signs of intoxication are elevated heart rate; hallucinations; mydriasis; agitation; vomiting; and seizures; these signs are common in the serotonin syndrome. Indole is structurally similar to serotonin (5-HT), has activity on 5-HT receptors and is typically identified within indoleamine hallucinogens such as DMT. While 5-HT2A receptors are the primary site of action for DMT (typically producing visual geometric hallucinations in the users), the agonism of 5-HT2A receptors contributes substantially to the development of the serotonin syndrome. Conclusions: Beside the well-known cannabimimetic properties, SC drugs could have additive hallucinogenic effects due to the indole mojeties incorporated in their structures. SCs intake/intoxication can produce acute signs/symptoms/clinical findings belonging to the serotonin syndrome. Literature Reference [1] Spaderna, M., Addy, P.H., D’Souza, D.C., 2013. Spicing thin
Mobility of toxic elements in carbonate sediments from a mining area in Poland
No full textOspina-Alvarez, N., Głaz, L., Dmowski, K., & Krasnodębska-Ostręga, B. (2014). Mobility of toxic elements in carbonate sediments from a mining area in Poland. Environmental Chemistry Letters, 12, 435–441. doi:10.1007/s10311-014-0468-
Self-compression of 4.9 µm pulses to sub-40 fs with 2 mJ energy in Zinc Sulfide
No full textNonlinear self-compression of few-cycle multi-mJ pulses at 4.9 µm in ZnS is presented. 80 fs input pulses are compressed to 37 fs with 2.1 mJ energy at a 1 kHz repetition rate. © 2024 The Author(s
Correction to: Chamoun et al., Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection
No full textChamoun MN, Blumenthal A, Sullivan MJ, Schembri MA, Ulett GC. 2018. Bacterial pathogenesis and interleukin-17: interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology. https://doi.org/10.1080/1040841X.2018.1426556.
When the above article was first published online, the below three corrections were missed.
The author ‘Antje Blumenthal’ was wrongly affiliated to the affiliation “cSchool of Chemistry and Molecular Biosciences, and Australian Infectious Disease Research Centre, The University of Queensland, Brisbane, Australia”. Now this affiliation has been removed for this author.
The affiliation ‘bTranslational Research Institute, The University of Queensland Diamantina Institute, Woolloongabba, Australia’ of the author ‘Antje Blumenthal’ should read ‘bThe University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia’.
In Table 3, the sentence ‘Benefit of manipulating IL-17 levels to improve immunization strategies M. tuberculosis’ should read “Benefit of manipulating IL-17 levels to improve immunization strategies against M. tuberculosis”.No Full Tex
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