4,943 research outputs found

    Evaluation of coronary flow with computed tomography derived FFR: Advantages and pitfalls

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    Coronary computed tomographic angiography (CCTA) is an excellent noninvasive, anatomic imaging modality for direct visualization of coronary arteries and for the assessment of coronary artery disease (CAD). CCTA has high sensitivity and high negative-predictive value for the identification of obstructive CAD; however, its specificity and positive-predictive value are low. After more than a decade of using CCTA to assess the anatomic severity of CAD, novel modalities of obtaining functional information from CCTA have been developed to increase its specificity and accuracy. These modalities use computational fluid dynamics to calculate fractional flow reserve (FFR) from CCTA datasets. Computed tomography-derived FFR (FFRCT) predicts virtual hyperemia for computation. Therefore, no additional image acquisition, medication, radiation exposure, or pharmacologic stress agent during CCTA examination are necessary for the calculation of FFRCT. Multiple, prospective single or multicenter studies have shown that FFRCT is poised to become a gate-keeper for catheterization laboratory. In this article, we aim to review the principles, diagnostic accuracy, advantages, limitations, and pitfalls of FFRCT

    Thickness of carotid intima and epicardial fat in rosacea: a cross-sectional study

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    Abstract: Background: Rosacea is a chronic facial skin disease associated with excessive inflammatory response to various triggers. Although some studies have supported the increased risk of cardiovascular diseases in rosacea, it has not been completely accepted. Objective: We aimed to investigate epicardial fat thickness and carotid intima-media thickness as cardiovascular risk predictors in rosacea patients. Methods: We conducted a cross-sectional study including 40 rosacea patients and 40 controls. Demographic data, epicardial fat thickness, carotid intima-media thickness, lipid parameters, biochemical parameters, presence of insulin resistance, and presence of metabolic syndrome of the participants were recorded. Results: Forty rosacea patients (31 female and 9 male) and 40 controls (30 female and 10 male) were enrolled in the study. Rosacea patients had significantly higher epicardial fat thickness and carotid intima-media thickness volumes than controls (P<0.001). In the multivariate logistic regression analysis, epicardial fat thickness was independently related to presence of rosacea (P<0.001, OR=13.31). In the multiple linear regression analysis, the epicardial fat thickness was independently associated with rosacea (β= 0.47, P<0.001), carotid intima-media thickness (β= 0.36, P<0.001), and systolic blood pressure (β=0.19, P=0.015) and the carotid intima-media thickness was independently associated with epicardial fat thickness (β= 0.6, P<0.001). The epicardial fat thickness levels were correlated with carotid intima-media thickness (r=0.63, P<0.001), LDL (r=0.23, P=0.037), systolic blood pressure (r=0.45, P<0.001), and diastolic blood pressure levels (r=0.37, P=0.001). The carotid intima-media thickness levels were correlated with epicardial fat thickness (r=0.63, P<0.001), systolic blood pressure (r=0.04, P<0.001), and diastolic blood pressure levels (r=0.27, P=0.016). Study limitations: The small number of participants. Conclusions: Examination and follow-up of rosacea patients for cardiovascular diseases may be recommended practices

    SOCIO-ECONOMIC IMPACT OF SUPPORT TURKISH NGOs ON DEVELOPING COUNTRIES: SADAKATASI ASSOCIATION

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    Makale, İbrahim Güran Yumuşak’ın danışmanlığında Hacı Altun tarafından hazırlanan “Türkiye’deki Sivil Toplum Kuruluşlarının Az Gelişmiş Ülkelere Sosyo-Ekonomik Katkıları: Sadakataşı Derneği Örneği” başlıklı yüksek lisans projesine dayalı olarak hazırlanmış ve güncellenmiştir. -- Prof. Dr. İstanbul S. Zaim Üniversitesi, [email protected] -- Sadakataşı Derneği, İstanbul, [email protected]ünümüzde Sivil Toplum Kuruluşları gün geçtikçe önemi artan ve etki alanı genişleyen bir işleve sahip olmaktadır. STK’larının güçlenmesi ve büyümesi, devletin üzerinden sosyal sorumluluk kapsamındaki yükleri azaltmaktadır. STK’ların bir bölümü sadece kendi ülkesi sınırları içerisinde değil diğer ülkelere yönelik faaliyetlerde bulunmaktadırlar. Son on yılda Türkiye’de, başta Osmanlı hinterlandında bulunan ülkeler olmak üzere birçok az gelişmiş ülke ve bölgelere yönelik faaliyetler gerçekleştiren STK’ların sayısı oldukça artmıştır. Makalede, Türkiye sınırları dışında faaliyet gösteren STK’lardan biri olan Sadakataşı Derneği’nin az gelişmiş ülke ve bölgelere yönelik yaptığı faaliyetler analiz edilerek sosyo-ekonomik katkıları incelenmektedir. Az gelişmiş ülkelere yapılan eğitim, sağlık ve gıda yardımları, ülkenin beşeri sermaye potansiyelini geliştirmekte ve iktisadi hayatı canlandırmaktadır. Bunun yanısıra kabullenilmiş fakirlik algısının kırılmasına ve Türk halkıyla bölge insanı arasında dostluk bağlarının güçlenmesine önemli katkılar sağlamaktadır.Today, Civil Society Organizations (NGOs) have an increasingly important and expanding role. Strengthening and growing NGOs reduces the burden of the state concerning social responsibility. Some of the NGOs are engaged not only in their own borders but also in other countries. Over the past decade, the number of NGOs in Turkey, especially those active in the hinterlands of the Ottoman Empire, has been increasing. In this article, the socio-economic contributions of the Sadakataşı Association, one of the NGOs operating outside the borders of Turkey, are analyzed by examining the activities of the association for the less developed countries and regions. Education, health and food aids made to underdeveloped countries improve the human capital potential of the country and stimulate the economic life. Besides, it contributes to breaking the accepted perception of poverty and strengthening the bonds of friendship between the Turkish people and the people of the region

    Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults

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    Coronary artery disease (CAD) is uncommon in young adult patients. However, these patients have different risk factor profiles and high-risk coronary plaques are more common. The aim of this study was to examine the relations between the coronary plaque burden, plaque composition, serum non-high-density lipoprotein cholesterol (non–HDL-C) levels, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio in young adults. We analyzed a total of 551 patients under age 45 who had undergone coronary computed tomography angiography (CCTA). Coronary plaque characteristics were analyzed using CCTA. Multivariate linear regression analysis was used to assess the predictors of non-calcified plaque (NCB) and calcified plaque (CB) burdens. Serum non–HDL-C levels and TG/HDL-C ratio were higher in the coronary atherosclerosis patient group. Serum non–HDL-C levels and the TG/HDL-C ratio were higher in the obstructive CAD patient group. The plaque burden was positively correlated with non-HDL-C (r = 0.30; p < 0.001), and TG/HDL-C ratio (r = 0.18; p < 0.001).  NCB was positively correlated with age, gender, smoking status, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, serum triglycerides, hbA1c, non–HDL-C, and TG/HDL-C ratio. Non–HDL-C (β coefficient = 0.13; p = 0.023) and TG/HDL-C ratio (β = 0.10;  p = 0.042) were independent predictors of NCB. Serum non–HDL-C levels and TG/HDL-C were significantly associated with the presence and burden of coronary plaques. Serum non–HDL-C and TG/HDL-C ratios were independently associated with NCB, suggesting their use as easy-to-compute markers for identifying high-risk groups in young adults

    Rubaies of İbrahim Aczî kendî (The last 180 rubaies)

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    1881-1965 yılları arasında Konya&apos;da yaşayan İbrahim Aczî Kendî, Konya&apos;nın XX. yüzyılda yetiştirdiği önemli şair, gazeteci, araştırmacı, yazar, mutasavvıf ve folklorculardandır. Konya&apos;da öğretmenlik yapan İbrahim Aczî Kendî, Arapça ve Farsça öğrenerek kendini geliştirmiş, tasavvuf, edebiyat ve tarihle ilgili kitaplar hazırlamıştır. İbrahim Aczî Kendî&apos;nin bizzat kendisinin kaleme aldığı, tek nüshası Yusuf Ağa Kütüphanesinde 10465/1 numara ile kayıtlı olan Devr-i Zaman adlı eseri, 360 Farsça rubâî ve bu rubâîlerin Osmanlı Türkçesiyle yazılmış açıklamalarından oluşmaktadır. Bu çalışmada İbrahim Aczî Kendî&apos;nin hayatı incelenmiş, Devr-i Zaman adlı eserinde bulunan 360 rubâînin son 180 tanesi çalışılmıştır. Her bir rubâînin Farsça ana metinleri bilgisayar ortamına aktarılmış, bazen sadece tercüme, bazen de çeşitli açıklamalar içeren Osmanlı Türkçesiyle yazılan kısımlar ise latin harfleriyle aktarılmıştır. İbrahim Aczî Kendî, bu çalışmada ele alınan rubâîlerinde, genellikle ilahi aşk, toplumsal ahlâk, zamandan şikâyet, riya ve kibirden uzak durmanın gerekliliği gibi birçok konuya değinmiştir.İbrahim Aczî Kendî who lived the years between 1881 and 1965 in Konya is an important poet, a journalist, an investigate author, a mystic and a folklorist who raised by Konya in 20th century. İbrahim Aczî Kendi, worked as a tutor in Konya, improved himself by learning Arabian and Persian, prepared books about mysticism, literature and history. Devr-i zaman, which is written by İbrahim Aczî Kendî by himself and whose only transcript is registered with the number 104657/1 in Yusuf Ağa Library, is made of 360 Persian rubaies and their explanation which is written in Ottoman Turkish. In this study İbrahim Aczî Kendî&apos;s life and last 180 of 360 Persian rubaies are studied. Each of rubaies&apos; Persian main texts are transferred to electronic environment. Parts that sometimes include translation, sometimes also include various types of explanations written Ottoman Turkish are transferred with Latin letters. İbrahim Aczî Kendî, rubaies that handled in this study, touches on many topics, such as sociel ethics, complaints about today&apos;s youht, hypocrisy and staying away from and arrogance

    External interventions and the duration of civil wars

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    The authors combine an empirical model of external intervention, with a theoretical model of civil war duration. Their empirical model of intervention allows them to analyze civil war duration, using"expected"rather than"actual"external intervention as an explanatory variable in the duration model. Unlike previous studies, they find that external intervention is positively associated with the duration of civil war. They distinguish partial third-party interventions that extend the length of war, from multilateral"peace"operations, which have a mandate to restore peace without taking sides - and which typically take place at war's end, or at least when both sides have agreed to a cease-fire. In a future paper, the authors will examine whether partial third-party interventions - whatever their effect on a war's duration - increase the risk of war's recurrence. If that proves true, then even if interventions reduce the length of civil war, they may do so at the cost of further destabilizing the political system, and sowing the seeds of future rebellion.Children and Youth,Peace&Peacekeeping,Post Conflict Reconstruction,Post Conflict Reconstruction,International Affairs,Post Conflict Reconstruction,Social Conflict and Violence,Peace&Peacekeeping,Post Conflict Reconstruction,International Affairs
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