101,111 research outputs found
Active faulting and deformation of the Mongolian Altay mountains
No full textIn this thesis, I use multiple techniques to investigate the active faulting and deformation of the Altay Mountains, Western Mongolia. The Altay are an intracontinental transpressional mountain range, which are deforming in the far-field of the India-Asia collision. An anastomosing network of dextral faults strikes NNW-SSE, and accommodates NE-SW oriented shortening by rotating anticlockwise about vertical axes. I begin by characterising the Altay faults, and add to what is already known about their surface expression with new observations of active faulting and three previously undescribed ancient earthquake ruptures. I use 10Be cosmogenic dating and uranium-series dating on pedogenic carbonate to estimate the average Quaternary rate of slip for two of the major fault zones in the Altay. The slip rate on the Ölgiy fault is constrained to 0.3-2.1 mm/yr-1. Results from the Hovd fault are ambiguous, demonstrating the complications encountered with application of Quaternary dating techniques. I measure palaeomagnetic directions from Cretaceous to Pliocene-aged sediments in the eastern Altay to constrain the degree of anticlockwise rotation. Results from thermal demagnetisation of specimens indicate that the eastern Altay has not undergone significant rotation, in contrast with previous studies from the Siberian Altay that reveal almost 40 degrees of anticlockwise rotation. This suggests that the eastern-most Altay fault is too young to have experienced significant rotation, or is kinematically different from the Siberian Altay. I apply apatite fission track (AFT) dating and track length modeling to the central Altay. Results from AFT dating show rapid cooling in the late Cretaceous due to the distal assembly of Central Asia, suggesting that there was pre-existing topography at the start of the Late Cenozoic phase of deformation, the timing of which is constrained to have initiated at least 20 Myr ago. My work demonstrates that combining results from techniques that cover a variety of time scales quantifies the evolution of active faulting and deformation in the region
Adenozinin yardımcı T hücresi yanıtlarının regülasyonundaki moleküler mekanizmaları
No full textCataloged from PDF version of article.Includes bibliographical references (leaves 56-68).Polarizations of helper T cells into different functional subsets is important in order to influence the progression of immune-related diseases. One of the major outcomes in immune cell activation and generation of immunogenic response followed by TCR stimulation, is elevation of extracellular adenosine and upregulation of adenosine A2A receptors. Adenosine A2A receptor stimulation elevates intracellular cAMP to regulate helper T cell responses., Intracellular receptors of cAMP, PKA and EPAC proteins regulate cellular responses downstream of cAMP. In this study, we showed that adenosine differentially suppresses Th1 polarization rather than polarization of other functional T cell subsets. Adenosine signaling strongly decreased T cell accumulation in all the polarizing conditions except for Th2 condition. Adenosine-mediated decrease in T cell accumulation is associated with decreased proliferation and survival. PI3K-AKT pathway by targeting the Akt phospho-activation is one of the essential factors for regulation of immune response. One of the targets for Akt is Foxo1, which is inhibited by Akt phosphorylation. Foxo1 is known to suppress T cell proliferation and important in T cell trafficking and survival. Mechanistic studies have shown that adenosine signaling decreases the phosphorylation of Akt and Foxo1 molecules downstream of TCR. A Foxo1 inhibitor, AS1842856, reverses the reduction in T cell accumulation after adenosine receptor stimulation in particularly Th1 and Th17 conditions by increasing T cell survival in these conditions rather than T cell proliferation. Further studies using PKA and EPAC specific analogs indicated that both pathways may be required for adenosine mediated suppression of Th1 polarization; however, PKA pathway alone is largely responsible from inhibition of T cell proliferation. Results of this study have major implications to understand potential cell-intrinsic effects of one of the major immunoregulatory pathways.by Altay Koyaş
P–T path, zircon U–Pb ages and tectonic implications of Devonian pelitic granulites in the southern Chinese Altay orogen
No full textThe Chinese Altay orogen is an important part of the giant Central Asian Orogenic Belt. However, its tectono–metamorphic evolution is still a matter of debate. Here, we report Devonian pelitic granulites at the Wuqiagou area in the southern Chinese Altay orogen. They are characterized by an assemblage of garnet + orthopyroxene + cordierite ± spinel + biotite + plagioclase ± K–feldspar + quartz + Fe–Ti oxides. Based on petrographic features and P–T estimates, together with phase equilibrium modeling in the NCKFMASHTO system, three metamorphic stages can be distinguished as follows: (1) pre–peak prograde (M1) stage, with small biotite–plagioclase– or spinel–bearing assemblages preserved as inclusions in garnets and P–T conditions of <4.0 kbar and 700–770 °C; (2) peak metamorphic (M2) stage, with an garnet–orthopyroxene–cordierite–bearing assemblage and P–T conditions of 4.2–5.2 kbar and 780–830 °C; and (3) post–peak retrograde (M3) stage, with the biotite–plagioclase–bearing intergrowth ..
On the fine spectrum of the operator B(r,s,t) over c0 and c
No full textAbstractWe determine the fine spectrum of the operator B(r,s,t) defined by a triple-band matrix over the sequence spaces c0 and c. This generalizes the spectrum of the second-order difference operator Δ2 and includes some other special cases such as the generalized difference operator B(r,s) of [B. Altay, F. Başar, On the fine spectrum of the generalized difference operator B(r,s) over the sequence spaces c0 and c, Internat. J. Math. Math. Sci. 18 (2005) 3005–3013], the difference operator Δ of [B. Altay, F. Başar, On the fine spectrum of the difference operator on c0 and c, Inform. Sci. 168 (2004) 217–224], the right shift and Zweier matrices
"Où se situe la Turquie ?" Essai de comparaison du degré de développement social et humain de quelques pays
No full textManço Altay. "Où se situe la Turquie ?" Essai de comparaison du degré de développement social et humain de quelques pays . In: CEMOTI, n°18, 1994. Le Tadjikistan existe-t-il? Destins politiques d'une nation imparfaite, sous la direction de Stéphane A. Dudoignon et Guissow Jahangiri. pp. 263-281
Queer and trans life: Anthropological futures
No full textAgainst a background marked by endless ordinary crises, widespread precarity, and disrupting critical events, Queer and Trans Life charts queer investments for the future. It examines the challenges and pleasures in marginal everyday experiences of gender and sexual dissidence and the labours of care and endurance which sustain a sense of sociality and community, often against all odds. It presents queer and trans anthropological research from emerging European contexts. Though occasionally posited as non-belonging, the volume demonstrates that queer anthropology in Europe continues to thrive by providing textured ethnographic analysis and timely interventions in anthropological theory
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Preface
No full textDate of Conference: 4-7 September 2006Conference name: ECCBR: European Conference on Case-Based Reasoning 200
Introduction: Queer and Trans life
No full textBook synopsis: Against a background marked by endless ordinary crises, widespread precarity, and disrupting critical events, Queer and Trans Life charts queer investments for the future. It examines the challenges and pleasures in marginal everyday experiences of gender and sexual dissidence and the labours of care and endurance which sustain a sense of sociality and community, often against all odds. It presents queer and trans anthropological research from emerging European contexts. Though occasionally posited as non-belonging, the volume demonstrates that queer anthropology in Europe continues to thrive by providing textured ethnographic analysis and timely interventions in anthropological theory
Vertical axis rotation (or lack thereof) of the eastern Mongolian Altay Mountains: implications for far-field transpressional mountain building
No full textThe Altay Mountains of Western Mongolia accommodate 10–20% of the current shortening of the India-Asia collision in a transpressive regime. Kinematic models of the Altay require faults to rotate anticlockwise about a vertical axis in order to accommodate compressional deformation on the major strike slip faults that cross the region. Such rotations should be detectable by palaeomagnetic data. Previous estimates from the one existing palaeomagnetic study from the Altay, on Oligocene and younger sediments from the Chuya Basin in the Siberian Altay, indicate that at least some parts of the Altay have experienced up to 39 ± 8° of anticlockwise rotation. Here, we present new palaeomagnetic results from samples collected in Cretaceous and younger sediments in the Zereg Basin along the Har-Us-Nuur fault in the eastern Altay Mountains, Mongolia. Our new palaeomagnetic results from the Zereg Basin provide reliable declinations, with palaeomagnetic directions from 10 sites that pass a fold test and include magnetic reversals. The declinations are not significantly rotated with respect to the directions expected from Cretaceous and younger virtual geomagnetic poles, suggesting that faults in the eastern Altay have not experienced a large degree of vertical axis rotation and cannot have rotated >7° in the past 5 m.y. The lack of rotation along the Har-Us-Nuur fault combined with a large amount of rotation in the northern Altay fits with a kinematic model for transpressional deformation in which faults in the Altay have rotated to an orientation that favours the development of flower structures and building of mountainous topography, while at the same time the range widens at the edges as strain is transferred to better oriented structures. Thus the Har-Us-Nuur fault is a relatively young fault in the Altay, and has not yet accommodated significant rotation
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