1,720,970 research outputs found
Hypericum perforatum L.: a medicinal plant with potential as a curative agent against obesity-associated complications
No full textWOS: 000581562900002PubMed ID: 33090307Obesity is a low-grade inflammatory disease that is getting increasingly common among adults and children and causes different complications. Insulin resistance, Type II diabetes, atherosclerosis, metabolic syndrome and hypertension are among the major health problems, that are associated with obesity. Some medications are used to treat obese individuals and metabolic surgery is recommended, if appropriate, for individuals with a BMI >= 40. Due to the fact that medications and metabolic surgery are not tolerated by all, researchers focus on alternative therapies. Medicinal plants comprise the most important group of these alternative treatments. Hypericum perforatum L. is the medicinal plant, which we focused on in this study. Hypericum perforatum L. has been recognized as a medicinally valuable plant for over 2000 years. It has been used for generations to treat anxiety, depression, insomnia, gastritis, hemorrhoids, wounds, and burns. Recent studies have indeed shown promising effects for the treatment of obesity. In this study, 3T3-L1 adipocytes were used to mimic the adipocyte differentiation associated with obesity in cellular terms. Lipoprotein lipase (Lpl), Diacylglycerol-O-acyltransferase 1 (Dgat1), Fatty acid synthase (Fasn) markers were used to study the lipid accumulation, and Collagen V (ColV) was used to study cell elasticity to investigate the relationship of the effects of the administration of Hypericum perforatum L. with obesity.Scientific Resarch Project (BAP) Grant from the Mula Stk Kocman University [AR-GE 17/059]This work was supported by the Scientific Resarch Project (BAP) Grant (AR-GE 17/059) from the Mula Stk Kocman University granted to Dr. Filiz ALTAN. Authors would like to thank to Dr. Reat uNAL for valuable scientific support and critical reading; to Dr. Zekiye Buket YILMAZ for critical reading and language editing; to Dr. Guven GoRK and Dr. Olcay CEYLAN for providing the plant material and to Dr. Mehmet VAROL for his expertise and assistance in technical editing
Transcriptional analyses of the effects ofCatharanthus roseusL. medicinal plant extracts on some markers related to obesity and inflammation in 3T3-L1 mouse cell lines
No full textWOS: 000549674500002Catharanthus roseusL. (C. roseus) is one of the medicinal plants used to treat diabetes. In this study, 3T3-L1 preadipocyte cell lines which are fully differentiated into adipocytes were utilized and these were treated with extracts derived from above ground part ofC. roseus.The effect of these extracts on obesity and inflammation markers in cells was examined at the transcriptional level. Adipocyte lipid contents were measured by Oil Red O staining. Analyses, including changes related to adiposity and inflammation, were evaluated by measuring the relative mRNA expression levels of the genes of interest by the Real Time Reverse Transcription-Polymerase Chain Reaction (RT-PCR) method. The appropriate dose and durations forC. roseuswere determined to be 12.5 mu g/mL and 24- and 48 h respectively. The expression of the inflammation marker Interleukin-6 (Il-6) was decreased whenC. roseusextract was administered to fully differentiated 3T3-L1 cells according to the determined dose and durations. Lipoprotein lipase (Lpl) and Fatty acid synthase (Fasn) gene expressions in fully differentiated cells decreased compared to the control after 24 h however, this effect was not observed after 48 h. Collagen V, has also been shown to be affected by treatment of fully differentiated 3T3-L1 cells with plant extracts in both 24- and 48-h periods.Scientific Research Project (BAP) Grant from the Mula Stk Kocman University [19/084/05/1/2]This work was supported by a Scientific Research Project (BAP) Grant (19/084/05/1/2) from the Mula Stk Kocman University to Dr. Filiz ALTAN. We also would like to thank Dr. Mehmet VAROL for his expertise and assistance in language and technical editing
QTL ANALYSIS OF FIBER COLOR AND FIBER QUALITY IN NATURALLY GREEN COLORED COTTON (Gossypium hirsutum L.)
No full textImproving fiber quality of naturally colored cotton has become more important in recent years due to changes in the spinning technology and consumer demand. The identification of quantitative trait loci (QTL) closely linked to the fiber quality traits can allow marker assisted selection (MAS) which leads us to future's improved cotton cultivars. In this study, we performed genetic mapping on F-2 population of G. hirsutum (Yesil x Nazilli 84) intraspecific cross, and identified QTL for fiber color parameters (L, a, b, Delta L, Delta a, Delta b, Delta E) and fiber quality traits (fiber length, uniformity and elongation). The resulting genetic linkage map comprised of 123 amplified fragment length polymorphism (AFLP) markers and 27 linkage groups (LGs), covering 2068.5cM with an average distance of 16.8cM between two markers. Using single marker analysis a total of 43 QTL for fiber color parameters and fiber quality traits were identified, including four for fiber length, two for fiber uniformity, two for fiber elongation, five for L, four for a, four for b, eight for Delta L, four for Delta a, four for Delta b and six for Delta E. The identified QTL for fiber color parameters and fiber quality traits explained between 7.8% and 14.6% and between 5.9% and 14.7% of the phenotypic variation, respectively. Additionally, recombinant individuals having green fiber color together with long fiber length, high fiber uniformity and elongation were obtained in the segregating population. These individuals can be used to develop new cotton varieties in the future.Scientific and Technological Research Council of Turkey [104O589
Responses of the tomato (Lycopersicon esculentum Mill.) plant to exposure to different salt forms and rates
No full text0000-0001-5123-0031WOS: 000257693600010We aimed to investigate the effects of NaCl and Na(2)SO(4) on seed and pollen germination of tomato (Lycopersicon esculentum Mill.) in vitro. In addition, the effects of NaCl, Na(2)SO(4), and CaCl(2) on yield and quality, plant growth, some physiological parameters, and the distribution of mineral composition in greenhouse grown tomato plants were investigated. Seed germination was affected by high salinity treatments (MS and 1/2 MS). Pollen germination and pollen tube length were significantly affected by salt forms and doses. Pollen germination was blocked by the above doses of 50 mM NaCl and 30 mM Na(2)SO(4). In the greenhouse experiment, with increasing concentration of all forms of salt, stomatal density, chlorophyll content, plant growth, and yield decreased. Reductions were higher in fruit yield and stomatal density in the NaCl treatment than those in Na(2)SO(4) and CaCl(2) treatments. Membrane permeability was impaired with increases in all 3 forms of salt concentrations, but the effect of NaCl treatment on membrane permeability was more striking compared to the other salt forms. Proline accumulation increased with increasing salt concentrations. The K and N concentrations decreased with increases in all 3 types of salt concentrations. Concentration of Ca decreased with increasing NaCl and Na(2)SO(4), but increased with CaCl(2) salt concentrations. The growth and yield reduction under both NaCl and Na(2)SO(4) stress may be due to the combined effects of lower rates of Ca, K, and N, and excess accumulation of Na, while in the CaCl(2) experiment the growth reduction may be related to lower rates of K and N and the high rate of Ca
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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