40 research outputs found
Interaction of poorphyromonas gingivalis protease (HRgpA) with epithelial cells
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Oral dysbiosis initiates periodontal disease in experimental kidney disease
No full textBackground and hypothesis: It is presently unclear why there is a high prevalence of periodontal disease in individuals living with chronic kidney disease. Whilst some have argued that periodontal disease causes chronic kidney disease, we hypothesized that alterations in saliva and the oral microenvironment in organisms with kidney disease may initiate periodontal disease by causing dysbiosis of the oral microbiota. Methods: Experimental kidney disease was created using adenine feeding and subtotal nephrectomy in rats, and by adenine feeding in mice. Loss of periodontal bone height was assessed using a dissecting microscope supported by micro-CT, light, confocal and electron microscopy, and immunohistochemistry. Salivary biochemistry was assessed using NMR spectroscopy. The oral microbiome was evaluated using culture-based and molecular methods, and the transmissibility of dysbiosis was assessed using co-caging and microbial transfer experiments into previously germ-free recipient mice. Results: We demonstrate that experimental kidney disease causes a reproducible reduction of alveolar bone height, without gingival inflammation or overt hyperparathyroidism but with evidence of failure of bone formation at the periodontal crest. We show that kidney disease alters the biochemical composition of saliva and induces progressive dysbiosis of the oral microbiota, with microbial samples from animals with kidney disease displaying reduced overall bacterial growth, increased alpha diversity, reduced abundance of key components of the healthy oral microbiota such as Streptococcus and Rothia, and an increase in minor taxa including those from gram-negative phyla Proteobacteria and Bacteroidetes. Co-housing diseased rats with healthy ones ameliorates the periodontal disease phenotype, whilst transfer of oral microbiota from mice with kidney disease causes periodontal disease in germ-free animals with normal kidney function. Conclusions: We advocate that periodontal disease should be regarded as a complication of kidney disease, initiated by oral dysbiosis through mechanisms independent of overt inflammation or hyperparathyroidism.</p
A Randomised Control Trial and Comparative Analysis of Multi-Dimensional Learning Tools in Anatomy
No full textResearch was funded by the Cakmak Lab and the University of Otago, Otago Medical School. Author notes: These authors contributed equally: Ben Kei Daniel and Mustafa Asil. Contributions: Conception and Design of Study: Y.C. and C.W.; Design of materials: Y.C. and C.W.; Randomization of participants: P.K.; Acquisition of data: C.W.; Data analysis and interpretation: Y.C., M.A., B.D. and C.W.; Drafting of manuscript and/or critical revision: C.W., Y.C., M.A., B.D. and P.K.; All authors read and approved the final manuscript.Peer reviewe
Special Session: AutoSoC: A Suite of Open-Source Automotive SoC Benchmarks
No full textThe current demands for autonomous driving generated momentum for an increase in research in the different technologies required for these applications. Nonetheless, the limited access to representative designs and industrial methodologies poses a challenge to the research community. Considering this scenario, there is a high demand for an open-source solution that could support development of research targeting automotive applications. This paper presents the current status of AutoSoC, an automotive SoC benchmark suite that includes hardware and software elements and is entirely open-source. The objective is to provide researchers with an industrial-grade automotive SoC that includes all essential components, is fully customizable, and enables analysis of functional safety solutions and automotive SoC configurations. This paper describes the available configurations of the benchmark including an initial assessment for ASIL B to D configurations.Accepted author manuscriptComputer EngineeringQuantum & Computer Engineerin
Hırs ve Başarı
No full textOrison Swett Marden's Hırs ve Başarı (Ambition and Success) is an inspirational self-help book focused on unlocking individual potential and living a fulfilling life. The author defines ambition not merely as a desire but as a divine impulse that constantly propels humans upward and forward. The book explains how a healthy ambition can overcome obstacles such as inertia, procrastination, and dissatisfaction, transforming an ordinary life into an extraordinary success story. While criticising "unworthy ambitions" focused solely on material gain, Marden emphasises the importance of "noble ambitions" centred on character development and contribution to society. Touching on the impact of the environment and the choice of friends on success, the author advocates the power of envisioning oneself in a better position and remaining loyal to that vision. The work conveys the message that, regardless of age or circumstances, humans can determine their own destiny by activating their latent powers.Orison Swett Marden'in Hırs ve Başarı adlı eseri, bireysel potansiyeli açığa çıkarma ve tatmin edici bir yaşam sürme üzerine odaklanan ilham verici bir kişisel gelişim kitabıdır. Yazar, hırsı (ambition) sadece bir istek değil, insanı sürekli yukarıya ve ileriye taşıyan, Tanrısal bir dürtü olarak tanımlar. Kitapta, sağlıklı bir hırsın; atalet, erteleme ve tatminsizlik gibi engelleri nasıl aşabileceği ve sıradan bir yaşamı nasıl olağanüstü bir başarı öyküsüne dönüştürebileceği anlatılır. Marden, sadece maddi kazanç odaklı "değersiz hırsları" eleştirirken, karakter gelişimini ve topluma katkıyı merkeze alan "asil hırsların" önemini vurgular. Çevrenin ve arkadaş seçiminin başarı üzerindeki etkisine değinen yazar, kişinin kendini daha iyi bir konumda hayal etmesinin (vizyonun) ve bu hayale sadık kalmasının gücünü savunur. Eser, yaş veya koşullar ne olursa olsun, insanın içindeki gizli güçleri harekete geçirerek kendi kaderini tayin edebileceği mesajını verir
ASIL upgrade of a safety element out of context
No full textAuthor: Marco TerlerScientific Paper Wien, FH Campus Wien 202
Strategic management of population programs
No full textFormal strategic planning and management appear to contribute to organizational effectiveness. The author surveys the literature on strategic management in private/for-profit organizations and applies lessons from that literature to population programs. Few would argue that population programs would not benefit from strategic planning and management, but it would be inadvisable to initiate the process when the organization is faced with a short-term crisis; during or immediately before a change in leadership; or when implementation is unlikely. Public sector programs seem to have the latitude to manage strategically. Models available for adoption include life-cycle models, strategic issues management, stakeholder analysis, and portfolio analysis. The model selected may be a function of: (1) who will use it (life-cycle/evolutionary models may be well-suited to the planning needs of donors); (2) the presence of challenges to the survival of the program or to key components of it (stakeholder analysis would find ready application in those circumstances); and (3) the relative success and stability of the program (portfolio analysis may help a program balance its activities in a stable environment whereas strategic issues management is useful in responding to a dynamic environment.) It is important to marshall top-level support, designatewho will do the leg work, analyze the organization's history and current situation, assess internal strengths and weaknesses and external threats and opportunities, and summarize critical issues facing the program. Then a strategy may be developed. Among the available approaches are: (1) scenario developments (useful for a program that senses a need to change its approach to clients); (2) critical issues analysis (useful for refining successful programs); and (3) a goal approach (useful for programs with diffuse, ill-defined objectives). There are no short-cuts, it is argued. A strategic plan typically contains: (1) a mission statement that describes the social need to be addressed, what is unique about the organization, what its values are, and who the principal stakeholders are; (2) a statement of the population to be served and goals for service delivery and quality standards; (3) a service delivery strategy; (4) a financial strategy; (5) a marketing strategy; and (6) support strategies. Most organizations will find that there is no ideal structure - all require tradeoffs - and that attention should focus on eliminating patently dysfunctional aspects of the structure.Health Monitoring&Evaluation,ICT Policy and Strategies,Agricultural Knowledge&Information Systems,Educational Sciences,Enterprise Development&Reform
Determined-Safe Faults Identification: A step towards ISO26262 hardware compliant designs
No full textThe development of Integrated Circuits for the Automotive sector imposes on major challenges. ISO26262 compliance, as part of this process, entails complex analysis for the evaluation of potential random hardware faults. This paper proposes a systematic approach to identify faults that do not disrupt safety-critical functionalities and consequently can be considered Safe. By deploying code coverage and Formal verification techniques, our methodology enables the classification of faults that are unclassified by other technologies, improving ISO26262 compliance. Our results, in combination with Fault Simulation, achieved a Diagnostic Coverage of 93% in a CAN Controller. These figures allow an initial assessment for an ASIL B configuration of the IP
Bibliometric examination of health tourism in the context of hygiene
No full textObjective: In recent years, health tourism has been increasing its importance in terms of both the development of national economies and improving the quality of health systems. Health tourism is summarized as the visit of people who demand treatment to different regions in order to access high-cost treatments outside the region where they live, often at lower prices. Health tourism is included in the literature not only in terms of access to lower-priced services, but also as a form of tourism that occurs when individuals who demand the service want to access quality services. This study aims to evaluate the publications on health tourism, which consumers apply in line with their needs, from different perspectives, to reveal the diffusion and relationships of existing studies and to examine the hygiene effect. Methods: The data used in this study were obtained from studies published only in the English language by filtering the studies in “Scopus” and “WoS” (Web of Science) databases between 2020–2024. In the retrieval of the data, restrictions were made as “health tourism” in titles, abstracts and keywords and “hygiene” in all fields. In the bibliometric analysis part, co-author analysis, keywords analysis, country citation analysis, author citation analysis, source citation analysis, and bibliographic matching analysis were performed, respectively, using the Vosviewer program. The geographical distribution of studies on health tourism was visualized using the R program and Biblioshiny plugin. Results: As a result of the review, it was determined that the studies searched in the WoS database consisted of 3512 research articles, 338 reviews, 217 early access publications, and 179 conference proceedings, while the publications in the Scopus database were 303 research articles, 55 reviews, 60 book chapters, and 24 conference proceedings. It has been observed that the number of studies conducted in the last five years has increased significantly, especially after the Covid-19 pandemic. In addition, the interconnections of studies on health tourism were evaluated from different perspectives. The countries, authors, and relationship tables that publish the most on the subject were revealed. Conclusion: It has been observed that studies on health tourism continue to increase every year. It has been determined that the research on health tourism is unevenly distributed on the basis of countries and that the leading countries in this field constitute a significant part of the total studies. The importance of hygiene concept in health tourism has been shown with the help of analysis results, tables and graphs
