22,353 research outputs found
Sonographic evaluation of experimental acute renal arterial occlusion in dogs
No full textSpies, J. B., Hricak, H., Slemmer, T. M., Zeineh, S., Alpers, C. E., Zayat, P., ... & Sandler, M. A. (1984). Sonographic evaluation of experimental acute renal arterial occlusion in dogs. American journal of roentgenology, 142(2), 341-346.PublishedN/
CE Challenges: Work to Do
No full textCE has been used for more than two decades now. Despite many successes and advantages, there are still many challenges to be addressed. These challenges are both technical and organisational. In the paper we will address the current challenges of CE. Many challenges are related to the exchange of data and knowledge and to the systems that make data and knowledge exchange possible. Although much progress has been made in enabling extensive data and knowledge exchange and use, much remains to be wished. For example, there are still barriers to data exchange. Technically, these barriers may consist of different formats, differences in infrastructures and systems, and different semantics. There are also organisational and political barriers. For example, investment in information system may heavily impact upstream suppliers, while revenues of better information exchange may predominantly be gained by downstream actors. Without sharing costs and revenues, chain-wide information exchange will not be easily realised. Another barrier is the possible lack of willingness to share information, because of potential misuse of knowledge and loss of power. The paper is organised as follows. First we will describe the current manifestation of CE as described in a recent book. Second, we will list current trends in CE. Third, we will present some Critical Success Factors (CSFs) that are considered relevant for implementing and adapting CE practices. Last, we indicate some research and practical questions to be addressed, especially for areas that have a high potential and actual impact. </p
Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression
No full textTo investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets. However, the cell-specific expression of many leukocyte receptors is difficult to characterize in vivo. Here, we report a protocol based on flow cytometry that allows simultaneous characterization of surface receptor expression on different subsets of infiltrating renal leukocytes. The described technique combines an adapted method to prepare single cell suspensions from whole kidneys with subsequent four-color flow cytometry. We recently applied this technique to determine the differential expression of murine chemokine receptors CCR2 and CCR5 on infiltrating renal leukocyte subsets. In this article, we summarize our current findings on the validity of the method as compared with immunohistology and in situ hybridization in two murine models of nonimmune ( obstructive nephropathy) and immune-mediated ( lupus nephritis) inflammatory renal disease. Flow cytometry analysis revealed an accumulation of CCR5-, but not CCR2-positive lymphocytes in inflamed kidneys, compared to the peripheral blood. Particularly renal CD8(+) cells expressed CCR5 (79% in obstructed kidneys, 90% in lupus nephritis). In both models, infiltrating renal macrophages were positive for CCR2 and CCR5. These data corresponded to immunohistological and in situ hybridization results. They demonstrate that flow cytometric analysis of single cell suspensions prepared from inflamed kidneys is a rapid and reliable technique to characterize and quantify surface receptor expression on infiltrating renal leukocyte subsets
Synthesis optimization and charge carrier transfer mechanism in LiLuSiO<sub>4</sub>:Ce, Tm storage phosphor
No full textLiLuSiO4:Ce and LiLuSiO4:Ce, Tm show very efficient charge carrier storage properties upon beta irradiation after samples have received treatment in vacuum. They outperform the commercial storage phosphor BaFBr(I):Eu2+ in many aspects. The influence of the synthesis conditions, Ce and Tm concentration, nonstoichiometry and codoping with Ca, Hf, Al and Ge are reported. Based on the results of the synthesis optimization, thermoluminescence (TL) emission and TL excitation spectra a mechanism of charge carrier transfer, storage, and recombination during irradiation and thermal or optical readout is proposed.Accepted Author ManuscriptRST/Fundamental Aspects of Materials and EnergyRST/Luminescence Material
Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice
No full textChemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine receptor-bearing leukocytes. Chemokines play important roles in leukocyte trafficking and blocking chemokines can effectively reduce renal leukocyte recruitment and subsequent renal damage. However, recent data indicate that blocking chemokine or chemokine receptor activity in renal disease may also exacerbate renal inflammation under certain conditions. An increasing amount of data indicates additional roles of chemokines in the regulation of innate and adaptive immune responses, which may adversively affect the outcome of interventional studies. This review summarizes available in vivo studies on the blockade of chemokines and chemokine receptors in kidney diseases, with a special focus on the therapeutic potential of anti-chemokine strategies, including potential side effects, in renal disease. Copyright (C) 2004 S. Karger AG, Basel
The impact of P(NDI2OD-T2) crystalline domains on the open-circuit voltage of bilayer all-polymer solar cells with an inverted configuration
No full textWe fabricated P(NDI2OD-T2)/PTB7 bilayer all-polymer solar cells with an inverted configuration, where the annealing temperature was systematically varied. The current density-voltage behavior was investigated and the structural properties of the P(NDI2OD-T2) layers were characterized. Absorption spectroscopy, surface morphology, and crystallite analysis showed that increasing phase segregation of P(NDI2OD-T2) films occurred as the annealing temperature increased. We found that, as the P(NDI2OD-T2) stacking improved, with larger domains, the open-circuit voltage decreased and the saturation dark current density increased. This work provides a guide for the processing of P(NDI2OD-T2) layers to maximize the power conversion efficiency of all-polymer solar cells. (C) 2015 Author(s).open1186sciescopu
Data and code for: Variational Graph Author Topic Modeling
No full textThis is the tensorflow implementation of KDD-2022 paper "Variational Graph Author Topic Modeling" by Delvin Ce Zhang and Hady W. Lauw.
VGATM is a Graph Neural Network model that extracts interpretable topics for documents with authors and venues. Topics of documents then fulfill document classification, citation prediction, etc.
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Updated analytical solutions of continuity equation for electron beams precipitation – I. Pure collisional and pure ohmic energy losses
No full textWe present updated analytical solutions of continuity equations for power-law beam electrons precipitating in (a) purely collisional losses and (b) purely ohmic losses. The solutions of continuity equation (CE) normalized on electron density presented in Dobranskis & Zharkova are found by method of characteristics eliminating a mistake in the density characteristic pointed out by Emslie et al. The corrected electron beam differential densities (DD) for collisions are shown to have energy spectra with the index of −(γ + 1)/2, coinciding with the one derived from the inverse problem solution by Brown, while being lower by 1/2 than the index of −γ/2 obtained from CE for electron flux. This leads to a decrease of the index of mean electron spectra from −(γ − 2.5) (CE for flux) to −(γ − 2.0) (CE for electron density). The similar method is applied to CE for electrons precipitating in electric field induced by the beam itself. For the first time, the electron energy spectra are calculated for both constant and variable electric fields by using CE for electron density. We derive electron DD for precipitating electrons (moving towards the photosphere, μ = +1) and ‘returning’ electrons (moving towards the corona, μ = −1). The indices of DD energy spectra are reduced from −γ − 1 (CE for flux) to −γ (CE for electron density). While the index of mean electron spectra is increased by 0.5, from −γ + 0.5 (CE for flux) to −γ + 1(CE for electron density). Hard X-ray intensities are also calculated for relativistic cross-section for the updated differential spectra revealing closer resemblance to numerical Fokker–Planck (FP) solutions
Introduction and Author Biographical Notes
No full textThe Introductory Notes include The Cutting EDge\u27s mission statement, editorial board, founder\u27s note, and author\u27s biographies
From the Editors and Author Biographical Notes
No full textLetter from the Editors and Author Biographical Note
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