8 research outputs found
Tinea kapitisli hastalarda itrakonazol terbinafin tedavisinin etkinliğinin değerlendirilmesi
No full textGriseofulvin günümüzde dünyanın bir çok yerinde tinea kapitis tedavisinde onay almış tek oral antifungal ajandır. Griseofulvine alerjisi olan, tolere edemeyen ya da cevap alınamayan olgularda alternatif bir tedavi gerekmektedir. Son yıllarda itrakonazol ve terbinafîn tedavisinin tinea kapitisli çocuklarda etkili ve güvenilir tedavi seçenekleri olduklarım gösteren çok sayıda çalışma vardır. Bu çalışmada tinea kapitisli çocuklarda itrakonazol ve terbinafîn tedavisinin etkinliği, yan etkileri ve tedavi maliyetleri değerlendirildi. Dicle Üniversitesi Tıp Fakültesi Dermatoloji Polikliniğine Aralık 2000 - Ocak 2003 tarihleri arasından başvuran 61 tinea kapitisli hasta arasında yaş, cinsiyet ve ağırlık açısından eşleştirme yapılan 50 çocuk seçildi. Hastaların ağırlıkları esas alınarak günlük doz oral yoldan itrakonazol 24 hastaya, terbinafîn 26 hastaya 4 hafta süreyle uygulandı. İtrakonazol ve terbinafîn tedavisinin etkinliği 2., 4., 8. ve 12. haftalarda klinik ve mikolojik muayene ile değerlendirildi ve 12. haftada etkin tedavi ve etkisiz tedavi şeklinde sınıflandırıldı. Tedavinin ikinci haftası ve tedavi bitiminde olası yan etkiler ve tolerabilite açısından hastalar ve ebeveynleri sorgulandı ve hastaların laboratuar testleri yapıldı. Takip dönemi sonunda itrakonazol grubunda %83,3, terbinafîn grubunda ise %92,3 oranında tedaviden etkin sonuç alındı. Her iki ajan istatiksel olarak etkili idi ( p<0,001). Her iki ilaç grubunda da tedavinin kesilmesine neden olabilecek yan etkilere rastlanmadı. İki grup arasında etkinlik açısından anlamlı bir fark bulunmadı (p: 0,202). Tedavi maliyetleri açısından terbinafîn tedavisinin daha ekonomik olduğu görüldü. Sonuç olarak; oral terbinafîn ve itrakonazol tedavisi tinea kapitisli çocuklarda etkili ve güvenli bulundu.Griseoftılvin is the only one oral antifungal agent that licensed worldwide for treatment of tinea capitis. Cases who are allergic to, intolerant of or nonresponsive to griseofulvin require an alternative therapy. In recent years, numerous study exist that demonstrated effectiveness and safety of itraconazole and terbinafine treatment in children with tinea capitis. In this study, effectiveness, side effects and cost of itraconasole and terbinafine treatment was evaluated in children with tinea capitis. Fifty children who were matched for age, sex and body weight were selected among 61 patients with tinea capitis that were admitted to the outpatient Clinic of Dermatology in Medical Faculty of Dicle University in the period of December 2000- January 2003. Itrakonazole was administrated daily oral dose on the basis of their weight to 24 patients, terbinafin to 26 patients for 4 weeks.The effectiveness of itraconazole and terbinafine therapy were evaluated clinically and mycologically examination at 2, 4, 8, 12th weeks and graded as effective therapy and ineffective therapy at 12th week. At the second week and the end of treatment, the patients and parents were questioned about side effects and tolerability, and laboratory tests were performed. At the end of the 12* week, the percentage of effective therapy were determined as 83,3% in itraconazole and 92,3 % in terbinafin group. Both agents were statistically effective (p < 0,001). There was no evidence of side effects to withdraw from therapy in both groups. There were no significant differences of effectiveness between two groups (p: 0,202). According to costs of treatment, terbmafin therapy was cheaper. In conclusion, we found that itraconazole and terbinafine treatment was effective and safe in children with tinea capitis
Aksiller hiperhidroz tedavisinde botulinum toksini: Bir olgu sunumu
No full textBackground: Localized idiopathic hyperhidrosis is a disorder of sweating, unknown pathogenesis. If conventional treatments remain ineffective, surgical treatments such as sympathectomy and excision of the active sweat glands, are alternatives. Previous studies have shown botulinum toxin's effect in reducing sweat production. We present a patient who have been treated effectively with botulinum toxin
The effect of domed and hip roof coverings on mosque design in case of fire
No full textThe architectural design seeks solutions to many problems, one of which is designing buildings that can quickly and safely evacuate people. Mosques, which are places of worship and multifunctional gathering centers for Muslims, are significant buildings in terms of fire research because they often host many people at the same time. However, there is a lack of research on fire safety in mosques. This study focuses on the consequences of different scenarios and types of mosque roof design, with a capacity of 500 people, as produced by the Turkiye Presidency of Religious Affairs. The examined scenarios are Scenario 1 (500 kW fire size) and Scenario 2 (1000 kW fire size), and the investigated roof types of mosques are Type 1 (hip roof) and Type 2 (dome). In the analyzed scenarios, it was observed that the dome roof type in the examined mosque design extended the evacuation time by around 10–35%. The dome creates a space for storing smoke, which reduces the spread of smoke in the main room and raises the ASET. This study recommends expanding the scope of future research by incorporating a greater variety of fire scenarios and roof covering types in mosques, while also investigating the impact of natural ventilation openings on evacuation times. © 2023 The Author
Author Correction: Retrospective analysis of pathological changes in the maxillary sinus with CBCT
No full textA new method of UA_CPE coupled with spectrophotometry for the faster and cost-effective detection of proline in fruit juice, honey, and wine
No full textThe study developed a new method for proline detection in honey, wine and fruit juice using ultrasound assisted-cloud point extraction (UA-CPE) and spectrophotometry. Initially, a quaternary complex was built, containing proline, histamine, Cu(II), and fluorescein at pH 5.5. Samples were treated with ethanol-water mixture before extraction and preconcentration, using an ultrasonic bath for 10min at 40 degrees C (40 kHz, 300W). After the optimization of variables affecting extraction efficiency, good linearity was obtained between 15 and 600 mu g L-1 with sensitivity enhancement factor of 105. The limits of detection and quantification were 5.7 and 19.0 mu g L-,(-1) respectively. The recovery percentage and relative standard deviations (RSD%) were between 95.3 and 103.3%, and 2.5 and 4.2%, respectively. The accuracy of the method was verified by the analysis of a standard reference material (SRM 2389a).Commission of Scientific Research Projects, Cumhuriyet University, (CUBAB) [F-480]This study was supported financially by Commission of Scientific Research Projects, Cumhuriyet University, (CUBAB) as research Project with code of F-480, conducted in control of the main author
Bibliometric analysis of 3D printing technology in the field of architecture: an education review
No full textWith the ease of access to 3D printers, innovative studies are carried out daily to bring new perspectives to the discipline of architecture and to produce new and creative ideas to solve existing problems. The primary purpose of this article is to explore the developments in architecture using 3D printing production by carrying out a bibliometric analysis of the 3D printer-related publications in the Web of Science database in the field of architecture. The publications between 2013 and 2023 were analyzed by keyword, author, countries, citation, affiliation, and source. VOSviewer and Biblioshiny software were used to display the results of the analysis graphically. Afterward, studies on the use of 3D printing in education were examined in detail. It was concluded that 3D printing has brought a new perspective and design flexibility to the field of architecture. However, the limitations of current technology and its potential impact on design processes remain a point of contentious discussion among students, academics, and practitioners
Glycaemic control and complications in haemodialysis patients: The TURK-HEMODIAB Study
No full textBackground The most common cause of end-stage kidney disease is diabetes mellitus (DM). The most commonly used renal replacement therapy in Turkey and in many countries around the world is haemodialysis (HD). Glycaemia control is important in these populations. In this study we aimed to screen for glycaemic control and complications in a large population of diabetic HD patients in Turkey. Methods A total of 16 043 patients were screened in 253 dialysis centres in Turkey and 5038 diabetic HD patients were included in the study. At participating centres, patients' diabetes history, complications, medications, haemoglobin A1c (HbA1c) and other laboratory data were reviewed and recorded by nephrologists. Results The average age of the patients was 64.0 ± 11.2 years and 56% were male. The mean HbA1c was 7.4 ± 1.5%. Patients were divided into three groups according to the HbA1c level (8%). As the HbA1c levels increased, the mean systolic blood pressure and diastolic blood pressure increased significantly. In addition, as the HbA1c levels increased, the number of patients with coronary artery disease, patients undergoing coronary artery bypass graft surgery and the rate of patients with diabetic retinopathy and vision loss increased. Diabetic foot disease and amputation rates were also higher in the group with poor glycaemic control. The number of patients using intensive or mixed insulin was also higher in the group with high HbA1c levels. In ordinal logistic regression analysis, age significantly decreased and higher body mass index slightly increased the risk of a higher HbA1c. Also, the need for a diabetic diet was greater in those with high HbA1c levels. Conclusion Our study highlights that the target values for diabetic HD patients in Turkey are partially compatible with the 2022 Kidney Disease: Improving Global Outcomes guidelines for diabetes management. Nevertheless, more effort and teamwork are needed to improve patient outcomes
