346 research outputs found
Phra Maha Katsapa ro phop Phra Si-an na Kakutthabatkhiri
No full textThe author illustrates the legend of Phra Maha Katsapa -- one of Lord Buddha's important disciples-- and his retreat in the Mount Kakutthabat. Phra Maha Katsapa was believed to wait in a cave on that mountain until the time Phra Si-an would reincarnate and achieve nirvana. The author also refers to recent attempt of a British Buddhist monk in finding the location of the mountain in India
Tetrasomy 18p: case report and review of literature
No full textShahad Bawazeer,1 Maha Alshalan,2 Aziza Alkhaldi,3 Nasser AlAtwi,3 Mohammed AlBalwi,1,3,4 Abdulrahman Alswaid,2 Majid Alfadhel,1,2,4 1Developmental Medicine Department, King Abdullah International Medical Research Center, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 2Department of Pediatrics, Genetic Division, King Abdullah Specialized Children Hospital, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 3Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; 4King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia Abstract: Tetrasomy 18p syndrome (Online Mendelian Inheritance in Man 614290) is a very rare chromosomal disorder that is caused by the presence of isochromosome 18p, which is a supernumerary marker composed of two copies of the p arm of chromosome 18. Most tetrasomy 18p cases are de novo cases; however, familial cases have also been reported. It is characterized mainly by developmental delays, cognitive impairment, hypotonia, typical dysmorphic features, and other anomalies. Herein, we report de novo tetrasomy 18p in a 9-month-old boy with dysmorphic features, microcephaly, growth delay, hypotonia, and cerebellar and renal malformations. We compared our case with previously reported ones in the literature. Clinicians should consider tetrasomy 18p in any individual with dysmorphic features and cardiac, skeletal, and renal abnormalities. To the best of our knowledge, we report for the first time an association of this syndrome with partial agenesis of cerebellar vermis. Keywords: tetrasomy 18p, chromosomal, isochromosome, 18p, dysmorphic, CGH microarray, chromosome, syndrom
Combining biomedical knowledge graphs and text to improve predictions for drug-target interactions and drug-indications
No full textBiomedical knowledge is represented in structured databases and published in biomedical literature, and different computational approaches have been developed to exploit each type of information in predictive models. However, the information in structured databases and literature is often complementary. We developed a machine learning method that combines information from literature and databases to predict drug targets and indications. To effectively utilize information in published literature, we integrate knowledge graphs and published literature using named entity recognition and normalization before applying a machine learning model that utilizes the combination of graph and literature. We then use supervised machine learning to show the effects of combining features from biomedical knowledge and published literature on the prediction of drug targets and drug indications. We demonstrate that our approach using datasets for drug-target interactions and drug indications is scalable to large graphs and can be used to improve the ranking of targets and indications by exploiting features from either structure or unstructured information alone.Mona Alshahrani, Abdullah Almansour and Asma Alkhaldi are supported by the National Center of Artificial Intelligence (NCAI), Saudi Data and Artificial Intelligence Authority (SDAIA), Saudi Arabia.Magbubah Essack has been supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) grant no. FCC/1/1976-20-0
al-Rawiyat de Maha Hasan: métamorphose et réincarnation comme dernière tentative pour préserver la vie
No full textAl-Rawiyat (The Storytellers) is a metafictional novel written by Syrian author Maha Hasan in 2014. The text contains two intertwined levels: the first is the inner monologue of a woman who is writing a novel; the second is represented by the stories of the characters she creates and that become themselves storytellers. In this text Maha Hasan explores the art of storytelling through multiple stories and many female characters. Ḥasan’s storytellers often live in parallel and imaginary worlds, in a permanent state of metamorphosis and perpetual reincarnation. The stories they live and narrate represent their last attempt to preserve life in an inhuman time that changes at a spasmodic rhythm and generates simultaneous events with contradictory effects. This novel translates into fiction the rapid changes of the present period, which—as affirmed by Rosi Braidotti in her Metamorphoses—does not truncate the brutality of power relations, but at deeper view, intensifies them to their point of implosion
PERGOLAKAN IDEOLOGI DALAM NOVEL TERJEMAHAN YANG MAHA KECIL KARYA ARUNDHATI ROY: KAJIAN HEGEMONI GRAMSCI (Ideological Upheavel in Arundhati Roy’s Translated Novel Yang Maha Kecil: The Study of Gramsci’s Hegemony)
No full textPenelitian ini bertujuan untuk mengungkap dan mendeskripsikan formasi ideologi dalam novel terjemahan Yang Maha Kecil karya Arundhati Roy,serta melihat hubungannya dengan ideologi pengarang dengan menggunakan kajian teori hegemoni yang digagas Antonio Gramsci. Tinjauan teori hegemoni Gramsci dalam penelitian ini melihat praktik hegemoni ideologi dalam Yang Maha Kecil melalui negosiasi ideologi yang dilakukan pengarang sebagai aparatur hegemoni. Metode yang digunakan adalah metode kualitatif melalui pendekatan deskriptif dan pemahaman arti secara mendalam. Penelitian ini menghasilkan temuan berupa teridentifikasinya sejumlah ideologi, yaitu ideologi (1) ultraortodoks (2) komunis, (3) anglofilia, (4) rasialisme, dan (5) patriarki. Adapun ideologi yang dinegosiasi ditunjukkan oleh ideologi komunisme dan ultraortodoks. Simpulan dari penelitian ini adalah adanya pertentangan dalam cara pandang pengarang tentang ideologi komunis dan ultraortodoks yang dinegosiasikan. Dalam hal ini, pengarang melihat bahwa ideologi komunis maupun ideologi ultraortodoks (agama) yang mengajarkan kesetaraan manusia secara sosial maupun di mata Tuhan, ternyata sama sekali tidak mengubah sistem pembedaan manusia.(This research aims to disclose and describe the formation of ideology in translated novel Yang Maha Kecil written by Arundhati Roy, as well as to recognize its relationship with the author’s ideology using Antonio Gramsci’s theory of hegemony. Gramsci’s hegemony theory is used in this research to observe the practice of ideological hegemony in Yang Maha Kecil through ideological negotiations practiced by the author as a hegemony apparatus. The method used is the qualitative one using the descriptive approach and extensive comprehension of meaning. This research produced findings in the form of identifying a number of ideologies, namely ideology (1) ultra-orthodox, (2) communism, (3) anglophilia, (4) racism, and (5) patriarchy. The negotiated ideology is demonstrated by communism and ultra-orthodox ideology. The conclusion of this research is that there is conflict in the author's perspective on communism and ultra-orthodox ideologies that are negotiated. In this case, the author sees that both communism and the ultra-orthodox (religion), which promote human equality both socially and religiously, apparently fail to change the system of human discrimination.
Receptor-targeted nanocarriers for tumor specific treatment and imaging
No full textLung cancer is the leading cause of cancer death in the United States. The efficacy of chemotherapy in lung cancer is limited by the development of cancer cell resistance during the treatment, difficulties in the delivery of anticancer drugs specifically to lung tumors, and severe adverse side effects of high doses chemotherapy on healthy organs. The main objectives of the present research are: (1) to provide effective delivery of therapeutic and imaging agents to lungs, (2) to mitigate the above described resistance, (3) to enhance the efficacy of lung cancer chemotherapy and limit adverse side effects of the treatment. To achieve these goals, we developed, characterized, and evaluated in vitro and in vivo on orthotopic model of lung cancer using a novel multifunctional tumor-targeted Nanocarrier-based Drug Delivery System (NDDS) composed of (1) a carrier; (2) a synthetic analog of Luteinizing Hormone-Releasing Hormone (LHRH peptide) as a targeting moiety; (3) an anticancer drug or imaging agent; (4) suppressors of drug resistance. We tested and compared: linear polymer, dendrimers and liposomes as nanocarriers; antisense oligonucleotides or small interfering RNA targeted to MRP1 and BCL2 mRNA as suppressors of pump and nonpump cellular resistance respectively; near-infrared cyanine dye Cy5.5, rhodamine, or fluorescein isothiocyanate as imaging agents.
The proposed multivalent NDDS exhibited preferential accumulation in the lungs, increased the sensitivity and specificity of tumor imaging, enhanced cancer treatment, and limited adverse side effects of the treatment on healthy organs. Targeting of nanocarriers to tumor specific receptors minimizes the influence of the architecture, composition, size, and molecular mass of nanocarriers on the efficacy of imaging and cancer treatment.
Local intratracheal administration sustained higher concentration of NDDS and its payload in the lungs and substantially limited their accumulation in other organs. Moreover, intratracheal local delivery of NDDS led to the more efficient treatment of lung cancer when compared with the intravenous administration of NDDS or free drugs. Simultaneous suppression of pump and nonpump resistance dramatically enhanced the cytotoxicity of the anticancer drug leading to a substantial increase in apoptosis induction.Ph.D.Includes bibliographical references
Gereja Hati Yesus Yang maha Kudus - Katedral (sejarah Gereja Katolik di Sulawesi Selatan dan Tenggara)
No full textThe Hati Yesus yang Maha Kudus Church is the oldest Catholic church in Makassar. Built in 1898, the church later became the cathedral church in Makassar. In this paper, the author makes the church as the object of research using the method of archaeological descriptions. This study aims to find out how the application of building styles in gothic churches and its changes to date. Through the embodiment of the visual elements of the oldest Catholic church in Makassar, the gothic style and other artistic styles of the buildings the church shows an interesting and unique blend of architecture. The shape of windows, doors, and curved roofs is part of the Gothic style that was the influence of the Dutch colonial period. Although the style and forms of this church have a resemblance of form with the later Christian church, the Christian church of Immanuel Makassar, the Hati Yesus yang Maha Kudus Church has become part of the Roman Catholic church structure which has many historical values, both in Makassar's local history, as well as Indonesian national history.
Keywords: Church of the Most Sacred Heart of Jesus, Catholic, history, Architecture, Makassar.

Gereja Hati Yesus yang Maha Kudus merupakan gereja Katolik tertua di Makassar. Dibangun pada tahun 1898, gereja ini kemudian men-jadi gereja Katedral di Makassar. Dalam tulisan ini, penulis menjadi¬kan gereja Hati Yesus yang Maha Kudus sebagai objek penelitian dengan menggunakan metode deskripsi arkeologis. Penelitian ini bertujuan untuk mengetahui bagaimana penerapan gaya bangunan pada gereja gotik dan perubahannya hingga saat ini. Melalui perwujudan unsur-unsur visual pada gereja Katolik tertua di Makassar tersebut, gaya gotik dan gaya artistik lainnya dari bangunan memperlihatkan perpaduan arsitektur yang menarik dan unik. Bentuk jendela, pintu, dan atap melengkung adalah bagian dari corak gotik yang merupakan pengaruh dari masa kolonial Belanda. Meskipun gaya dan bentuk gereja ini memiliki kemiripan bentuk dengan gereja Kristen yang muncul kemudian, yaitu gereja Kristen Immanuel Makassar, Gereja Hati Yesus yang Maha Kudus, menjadi bagian dari struktur gereja Katolik Roma yang memiliki banyak nilai-nilai sejarah, baik sejarah lokal Makassar, bahkan sejarah nasional Indonesia umumnya. 
Kata Kunci: Gereja Hati Yesus yang Maha Kudus, Katolik, sejarah, Arsitektur, Makassar.</jats:p
Suboptimal Attainment of Global Goals of Human Rights, Universal Health Coverage and Sustainable Development Goals in Gaza During 2023–2024
No full textMohammed Alkhaldi,1– 4 Bhavana Akilan,5 Maha Hoteit,6,7 Mohamed Elhadidy,8– 10 Suzanne Morrison11 1Department of Public Health, Faculty of Communication, Arts and Sciences, Canadian University Dubai, Dubai, United Arab Emirates; 2School of Physical and Occupational Therapy, Faculty of Medicine, and Health Sciences, McGill University, Montreal, QC, Canada; 3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, The University of Oxford, Oxford, UK; 4The Middle East and North Africa Regional Network, The Global Health Network, Dubai, United Arab Emirates; 5Global Leadership and Health Humanities, University of Toronto Scarborough, Toronto, Ontario, Canada; 6Faculty of Public Health, Lebanese University, Beirut, Lebanon; 7National Council for Scientific Research, Lebanon (CNRS-Lebanon), Beirut, Lebanon; 8Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza, Egypt; 9Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Zewail City of Science and Technology, Giza, Egypt; 10Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary, Medicine, Mansoura University, Mansoura, Egypt; 11Department of International Affairs and Social Sciences, College of Humanities and Social Sciences, Zayed University, Abu Dhabi, United Arab EmiratesCorrespondence: Mohammed Alkhaldi, Email [email protected]: The Israel military occupation, ongoing for over 75 years, has profoundly impacted the health and well-being of Palestinians. Despite longstanding calls for Universal Health Coverage (UHC) and sustainable development, the response of global health systems and organizations to crises such as the recent large-scale military assault on Gaza in October 2023 has been inadequate. There is a critical need to examine why these global health approaches have failed and how they can be restructured to address the unique challenges in Gaza effectively. This analysis aims to analyze the shortcomings of global health strategies in the context of the Gaza crisis during 2023– 2024, evaluate their alignment with UHC and the Sustainable Development Goals (SDGs), and propose actionable solutions to enhance their relevance and effectiveness in conflict-affected settings. The ongoing military assault has rendered Gaza uninhabitable, exacerbating mass human loss, destruction, health insecurity, and widespread social inequities. The crisis has highlighted the erosion of health systems and the inability to meet basic population needs. Global health strategies, as currently implemented, fail to address the specific challenges of Gaza, including ensuring human rights for health, achieving UHC, and advancing SDGs. These failures are rooted in a lack of context-specific adaptation, inadequate accountability, and unresponsive global health diplomacy. The analysis concludes that global health entities and organizations have been largely ineffective in responding to the Gaza crisis, resulting in significant inequities and failures in life-saving actions. To address these challenges, there is an urgent need to tackle the factors behind the ineffective role of these organizations and suboptimal attainment of global goals. This role of global health should be redefined. Reforming the existing global health architecture and shaping well-representative alliances by involving influential actors from the Global South is a priority. These alliances should prioritize accountability, advocacy, and diplomacy while developing innovative and context-specific approaches to safeguard human rights, achieve UHC, and promote sustainable development in Palestine.Keywords: global health, UHC, SDGs, health rights, Palestine, Gaz
Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals
No full textThe original version of this Article contained an error in the spelling of the author Maha Al-Asmakh, which was incorrectly given as Al-Asmakh Maha. This has now been corrected in the PDF and HTML versions of the Article.Scopu
Teknik Persuasif Dalam Buku Allah Maha Baik Karya Arum Faiza
No full textPersuasive Techniques in the Book of Allah is Good by Arum Faiza This research is entitled persuasive techniques in the book Allah is Good by Arum Faiza. The reason for choosing this title is because the book Allah is Good by Arum Faiza is a book that contains Islamic motivations so the author wants to know the persuasive techniques he uses. Persuasive techniques are important to study because of the conditions that the author must fulfill in his work as a motivational book. This research is a qualitative research by using data collection techniques through documentation and hermaneutic techniques. The method used is content analysis. This study uses the keraf theory (2007), the results of the persuasive technique research in the book Allah Maha Baik by Arum Faiza found 51 data, including persuasive techniques (1) Rationalization of 6 data or equivalent to 12%, (2) Identification of 6 data or equivalent to 12 %, (3) Suggestions as much as 30 data or equivalent to 59%, (4) Compensation as much as 4 data or as much as 7%, (5) Conformity as much as 2 data or equivalent to 4%, (6) Replacement not found, (7) Projection as much as 3 data or the equivalent of 6%. Thing. Based on the results of the research above, it can be concluded that the persuasive technique used by Arum Faiza in the book Allah is Good is more dominant in using the technique of suggestion because the book Allah is Good tends to use persuasion to influence other people, this persuasion is used to encourage readers to be motivated by words. -words used, followed by rationalization, identification, conformity, compensation and projection
- …
