1,721,154 research outputs found
Investigation of the relationship of platelet-related parameters with prediction of gram negative bacteremia and disease prognosis
Full text linkTıp Fakültesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim DalıAmaç: Platelet ilişkili parametrelerin Gram negatif bakteriyemiyi öngörmede ve prognozundaki rolünü değerlendirmek amaçlanmıştır. Gereç-Yöntem: 1 Aralık 2020 ile 31 Aralık 2022 tarihleri arasında hastanemize başvuran, Gram-negatif bakteriyemi tanısı alan hastalar retrospektif olarak incelenmiştir. Dahil edilen hastalar Gram negatif bakteriyemisi olup sepsisi olan ve Gram negatif bakteriyemisi olup sepsisi olmayan hastalar şeklinde iki gruba ayrılmış olup, ek olarak sağlıklı kontrol grubu eklenmiştir. Hastalara ait klinik veriler, laboratuvar sonuçları retrospektif olarak hastane otomasyon sisteminden elde edilmiştir. Veriler değerlendirilerek platelet ilişkili parametrelerin Gram negatif bakteriyemiyi öngörmede ve prognozundaki rolü irdelenmiştir. p<0,05 istatistiksel anlamlılık olarak kabul edilmiştir. Bulgular: Çalışmaya 100 hasta ve 100 sağlıklı kontrol grubu olmak üzere toplam 200 kişi dahil edildi. Hastaların 54'ü erkek (%54,0), 46'sı kadındı (%46,0). 77'sinde sepsis vardı (%77,0), 23'ünde sepsis yoktu (%23,0). MPV değerinin Gram negatif bakteriyemisi olan sepsis hastalarında daha yüksek olduğu, MPV artışının mortalite ile ilişkisi olduğu ve 10,75 fL'lik MPV seviyesinin Gram negatif bakteriyemi tahmini için %70,0 duyarlılığa ve %73,0 özgüllüğe sahip olduğu belirlenmiştir. P-LCR değerinin Gram negatif bakteriyemisi olan sepsis hastalarında daha yüksek olduğu, P-LCR artışının kötü prognostik olduğu ve 30,750 seviyedeki P-LCR düzeyinin Gram negatif bakteriyemi tahmini için %73,0 duyarlılığa ve %72,0 özgüllüğe sahip olduğu görülmüştür. PDW değerinin Gram negatif bakteriyemisi olanlarda daha yüksek olduğu, PDW artışının kötü prognostik olduğu ve 16,350 olarak belirlendiğinde PDW düzeyinin Gram negatif bakteriyemi tahmini için %67,0 duyarlılığa ve %85,0 özgüllüğe sahip olduğu bulunmuştur. Sonuç: Tam kan sayımı analizinde kolayca bakılabilen MPV, P-LCR ve PDW, özellikle Gram negatif sepsisi öngörmede ve Gram negatif bakteriyemide prognostik olarak değerlendirme yapmada faydalı olabilir. Anahtar Kelimeler: Gram negatif bakteremi, MPV, PDW, platelet, sepsisObjective: It was aimed to evaluate the role of platelet-related parameters in predicting and prognosing Gram-negative bacteremia. Materials-Methods: Patients diagnosed with Gram-negative bacteremia who were admitted to our hospital between December 1, 2020 and December 31, 2022 were examined retrospectively. The included patients were divided into two groups: patients with Gram-negative bacteremia but sepsis and patients with Gram-negative bacteremia but no sepsis, and a healthy control group was added. Clinical data and laboratory results of the patients were obtained retrospectively from the hospital automation system. The data were evaluated and the role of platelet-related parameters in predicting and prognosing Gram-negative bacteremia was examined. p<0.05 was accepted as statistical significance. Results: A total of 200 people, 100 patients and 100 healthy control groups, were included in the study. 54 of the patients were male (54.0%) and 46 were female (46.0%). 77 had sepsis (77.0%), 23 did not have sepsis (23.0%). It was determined that the MPV value was higher in sepsis patients with Gram-negative bacteremia, an increase in MPV was associated with mortality, and an MPV level of 10.75 fL had a sensitivity of 70.0% and a specificity of 73.0% for the prediction of Gram-negative bacteremia. It was observed that the P-LCR value was higher in sepsis patients with Gram-negative bacteremia, an increase in P-LCR was poor prognostic, and a P-LCR level of 30,750 had a sensitivity of 73.0% and a specificity of 72.0% for the prediction of Gram-negative bacteremia. It was found that the PDW value was higher in those with Gram-negative bacteremia, an increase in PDW was poor prognostic, and when set at 16.350, the PDW level had a sensitivity of 67.0% and a specificity of 85.0% for the prediction of Gram-negative bacteremia. Conclusion: MPV, P-LCR and PDW, which can be easily measured in complete blood count analysis, may be especially useful in predicting Gram-negative sepsis and making prognostic evaluations in Gram-negative bacteremia. Keywords: Gram negative bacteremia, MPV, PDW, platelet, sepsi
Yoğun bakim ünitesinde alt solunum yolu örneklerinde bakteri üreyen i?mmünkompetan hastalarda CMV reaktivasyonu
No full textAmaç: İmmünsüpresif hastalarda Sitomegalovirüs (CMV) reaktivasyonu görüldüğü ve bu durumun olumsuz klinik sonuçlara neden olduğu bilinmektedir. İmmünkompetan hastalarda ise immünsüpresif hastalara kıyasla CMV reaktivasyonu ile alakalı daha az veri bulunmaktadır. Bu çalışmada hastanemizde yoğun bakım ünitesinde (YBÜ) takip edilen, alt solunum yolu örneklerinde bakteri üremesi olan, immünkompetan kritik hastalarda CMV reaktivasyonu varlığını ve reaktivasyonun hastanede yatış günü, ventilatör günü ve mortalite gibi parametrelerle ilişkisini araştırmak amaçlanmıştır. Yöntem: Çalışmaya 01.05.2019 ve 31.03.2020 tarihleri arasında hastanemizde karışık YBÜ'de takip edilen, en az 48 saattir mekanik ventilatör desteği alan, A. baumannii ile ilişkili solunum yolu kolonizasyonu veya ventilatör ilişkili pnömoni (VİP) ön tanısı olan CMV IgG pozitif immünkompetan hastalar dahil edildi. Serum ve endotrakeal aspirat (ETA) örneklerinde Real-time PCR yöntemi ile CMV reaktivasyonu varlığı araştırıldı. Hastalar VİP ve sepsis tablosunda olanlar ve olmayanlar şeklinde iki gruba ayrıldı. Gruplar arasında CMV reaktivasyon oranları ve CMV DNA kopya sayıları karşılaştırıldı. P<0.05 istatistiksel anlamlılık olarak kabul edildi. Bulgular: Çalışmaya 22'si (%64,7) erkek, 12'si (%35,3) kadın olan, 72,2±10,4 (en az 48 – en çok 91) yaş ortalamasına sahip 34 hasta dahil edildi. 27 hastada CMV reaktivasyonu görüldü (%79,4). VİP ve sepsis tablosunda olan hastalarda olmayanlara kıyasla CMV DNA kopya sayısı 5,8 kat fazlaydı ancak bu fark istatistiksel olarak anlamlı bulunmadı (p=0,717). Serumda CMV reaktivasyonu saptanan hastalarda hem hastanede yatış günü hem de ventilatör günü daha fazla bulundu (p=0,047, 0,036). CMV reaktivasyonu ile mortalite arasında ilişki saptanmadı (p=0,774). Sonuç: Çalışmamızda YBÜ'de alt solunum yolu örneklerinde bakteri üreyen immünkompetan hastalarda CMV reaktivasyon oranı %79,4 olarak saptandı ve bu oranın ulaşılabildiği kadarıyla literatürdeki en yüksek ikinci reaktivasyon oranı olduğu görüldü. Ayrıca bu reaktivasyonun uzamış hastane yatışı ve uzamış mekanik ventilatör süresi gibi olumsuz klinik sonuçlarla ilişkili olduğu görüldü. CMV reaktivasyonunu artıran faktörlerin ve reaktivasyonun yarattığı klinik sonuçların incelendiği büyük örneklem hacmine sahip çok merkezli gözlemsel çalışmalara ihtiyaç vardır. Bu çalışmalar sayesinde YBÜ'de takip edilen hastalar arasında kimlerin yüksek CMV enfeksiyonu riskine sahip olduğu aydınlatılacaktır.Objective: It is known that cytomegalovirus (CMV) reactivation is seen in immunosuppressive patients and this situation causes adverse clinical outcomes. There is less data on CMV reactivation in immunocompetent patients compared to immunosuppressed patients. In this study, we aimed to investigate CMV reactivation in immunocompetent critically ill patients with bacterial growth in lower respiratory tract samples followed in the intensive care unit (ICU) in our hospital, and to investigate the relationship of reactivation with outcomes such as length of stay (LOS), duration of mechanical ventilation, and mortality. Method: CMV IgG positive immunocompetent patients followed in our mixed ICU between 01.05.2019 and 31.03.2020, mechanically ventilated for at least 48 hours, respiratory tract colonization with A. baumannii or a preliminary diagnosis of ventilator-associated pneumonia (VAP) was included in the study. CMV reactivation was investigated by Real-time PCR method in serum and endotracheal aspirate (ETA) samples. The patients were divided into two groups as those with VAP and sepsis and those without. CMV reactivation rates and CMV DNA levels were compared between the groups. P<0.05 was accepted as statistical significance. Results: 34 patients, 22 (64.7%) male and 12 (35.3%) female, with a mean age of 72.2±10.4 (minimum 48 – maximum 91) were included in the study. CMV reactivation was seen in 27 patients (79.4%). CMV DNA level was 5.8 times higher in patients with VAP and sepsis compared to patients without, but this difference was not statistically significant (p=0.717). Both LOS and duration of mechanical ventilation were higher in patients with CMV reactivation in the serum (p=0.047, 0.036). There was no relationship between CMV reactivation and mortality (p=0.774). Conclusion: In our study, the rate of CMV reactivation in immunocompetent patients with bacterial growth in lower respiratory tract samples in the ICU was 79.4%, and this rate was the second highest reactivation rate in the literature as far as could be reached. In addition, this reactivation was associated with adverse clinical outcomes such as prolonged hospitalization and prolonged mechanical ventilation. There is a need for multicenter observational studies with large sample sizes to examine the factors that increase CMV reactivation and the clinical consequences of reactivation. These studies will elucidate who among the patients followed in the ICU has a high risk of CMV infection
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Investigation of the prognostic value of serum salusin-? and salusin-? levels at the time of admission in COVİD-19 patients
No full textAmaç: Vasküler inflamasyon, Yeni koronavirüs hastalığı 2019 (COVID-19)'un gelişmesinde ve ilerlemesinde önemli bir rol oynar. Ayrıca yüksek sitokin seviyesi COVID-19'da kötü prognoza işaret eder. COVID-19 hastalarının takibinde akut dönemde hastalığın şiddetini ve komplikasyonlarını belirlemek için, mikro ve makro damar yapılardaki endotel patofizyolojisini belirlemek ve endotel fonksiyon testlerini takipte kullanmak düşünülmelidir. Bu çalışmada COVID-19 hastalığının akut döneminde hastalığın şiddetini belirlemede salusin-α ve salusin-β peptidlerinin kullanılabilirliğinin araştırılması amaçlandı. Yöntem: Çalışmaya 01.09.2021 ve 01.03.2022 tarihleri arasında hastanemizde erişkin pandemi yataklı servisi ve erişkin yoğun bakım ünitesinde yatarak takip edilen, oral veya nazofarengeal sürüntü örneklerinde SARS-CoV-2 PCR testi pozitif saptanan hastalar dahil edildi. Çalışmamıza 74 COVID-19 tanılı hasta ve 37 kontrol grubu olmak üzere toplamda 111 katılımcı dahil edildi. Çalışmaya alınan hastalarda, takipte yoğun bakım ünitesi ihtiyacı veya mortalite gelişmesi birincil sonlanım noktası olarak kabul edildi. Hasta grubu; birincil sonlanım noktasına ulaşmaksızın komplikasyonsuz taburcu edilen hastalar ve birincil sonlanım noktasına ulaşan hastalar olarak ikiye ayrıldı. Başvuru anında alınan serum örneklerinden salusin-α ve salusin-β seviyeleri istatiksel olarak kıyaslandı. P<0.05 istatistiksel anlamlılık olarak kabul edildi. Bulgular: Çalışmaya dahil edilen hastaların 42'si (%56,8) erkek ve 32'si (%43,2) kadındı. Çalışma popülasyonunun yaş ortancası 67,5 (en az 25, en çok 97) yıldı. Birincil sonlanım noktasına ulaşan hastalardaki salusin-β seviyeleri; hem ulaşmayan hastalara göre (p=0,008) hem de sağlıklı kontrol grubuna göre (p=0,008) istatiksel olarak anlamlı derecede yüksek bulundu. Gruplar arasında salusin-α seviyeleri arasında ise istatiksel olarak anlamlı fark saptanmadı (p=0,279). Sonuç: Çalışmamızda birincil sonlanım noktasına ulaşan hastalarda ulaşmayan hastalar ve sağlıklı kontrol grubuna göre salusin-β seviyelerinin belirgin olarak daha yüksek olduğu saptandı. Yapılan ROC eğri analizine göre salusin-β seviyesinin 12,45 pg/ml olması, birincil sonlanım noktası tahmini için %83,8 duyarlılık ve %40,5 özgüllük ile yoğun bakıma yatış veya mortalite gibi komplikasyon gelişme riskini öngördürmektedir. Elde edilen veriler hipotezimizi desteklemekle birlikte, salusinlerin COVID-19 prognozunu belirlemesinin değerlendirilmesi için büyük örneklem hacmine sahip çok merkezli gözlemsel çalışmalara ihtiyaç vardır.Objective: Vascular inflammation has an important role in the development and progression of Novel coronavirus disease 2019 (COVID-19). Also, high cytokine level predicts poor prognosis in COVID-19. In order to determine the severity and complications of the disease in the acute period in the follow-up of COVID-19 patients, it should be considered to determine the endothelial pathophysiology in micro and macrovascular structures and to use endothelial function tests in the follow-up. In this study, it was aimed to investigate the utility of salusin-α and salusin-β peptides in determining the severity of the disease in the acute period of COVID-19. Method: Patients who were followed up in our hospital adult COVID-19 pandemic clinic and adult intensive care unit (ICU) between 01.09.2021 and 01.03.2022 and who were found to have positive SARS-CoV-2 PCR test in oral or nasopharyngeal swab samples were included in the study. In total, 111 patients were included in our investigation, of which 37 were in the control group and 74 had a COVID-19 diagnosis. The primary endpoint was the need for intensive care unit or mortality in the patients included in the study. The patients were divided into two groups those who did not reach the primary endpoint and were discharged without complications and those who reached the primary endpoint. Salusin-α and salusin-β levels of serum samples taken at the time of application were statistically compared. P<0.05 was accepted as statistical significance. Results: Of the patients included in the study, 42 (56.8%) were male and 32 (43.2%) were female. The median age of the study population was 67.5 (minimum 25, maximum 97) years. Salusin-β levels in patients reaching the primary endpoint; It was found to be statistically significantly higher than both the patients who did not reach (p=0.008) and the healthy control group (p=0.008). There was no statistically significant difference in salusin-α levels between the groups (p=0.279). Conclusion: In this study, salusin-β levels were found to be significantly higher in patients who reached the primary endpoint compared to patients who did not reach the primary endpoint and the healthy control group. The results of the ROC curve analysis showed that a salusin-β level of 12.45 pg/ml predicts the risk of complications such as ICU admission or mortality, with a sensitivity of 83.8% and a specificity of 40.5% for the estimation of the primary endpoint. The obtained data support our hypothesis, but multicenter observational studies with larger sample sizes are needed to evaluate salusins' determination of COVID-19 prognosis
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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