3,142 research outputs found
Free Will Conceptualization Systematic Review Non Pre-Registered Analysis Datafile and Code
No full textThis page is for the non-pre-registered correlation analysis regarding the number of years ago and the sample size, as suggested by the peer reviewer Prasad Chandrashekar. For other materials of this project led by Alison Lam (first author) and Siu Kit Yeung as co-author (second author), please see https://osf.io/2t67z
Control and Filtering for Discrete Linear Repetitive Processes with H infty and ell 2--ell infty Performance
No full textRepetitive processes are characterized by a series of sweeps, termed passes, through a set of dynamics defined over a finite duration known as the pass length. On each pass an output, termed the pass profile, is produced which acts as a forcing function on, and hence contributes to, the dynamics of the next pass profile. This can lead to oscillations which increase in amplitude in the pass to pass direction and cannot be controlled by standard control laws. Here we give new results on the design of physically based control laws for the sub-class of so-called discrete linear repetitive processes which arise in applications areas such as iterative learning control. The main contribution is to show how control law design can be undertaken within the framework of a general robust filtering problem with guaranteed levels of performance. In particular, we develop algorithms for the design of an H? and dynamic output feedback controller and filter which guarantees that the resulting controlled (filtering error) process, respectively, is stable along the pass and has prescribed disturbance attenuation performance as measured by and – norms
Safety and long-term efficacy of fractional CO2 laser treatment in women suffering from genitourinary syndrome of menopause
No full textAbstract not availableFariba Behnia-Willison, Sara Sarraf, Joseph Miller,*, Behrang Mohamadi,
Alison S. Care, Alan Lam, Nadia Willison, Leila Behnia, Stefano Salvator
Development and application of rhodium-catalysed ynamide carbometallation reactions
No full textHighly stereo- and regioselective rhodium-catalysed carbometallations of ynamides
using organometallic reagents have been disclosed. The scope of the process was
explored, and investigations revealed that Rh(cod)(acac) acts as an effective
precatalyst for carbometallation of ynamides using a range of organozinc reagents. A
plausible mechanism has been suggested where an alkenylzinc intermediate is
formed. This species has been exploited in further transformations with electrophiles
and in cross-coupling reactions, thus providing access to multisubstituted enamides
in a stereo- and regioselective manner. It was also possible to carry out the carbometallation of ynamides using organoboron
reagents by using [Rh(cod)(MeCN)2]BF4 as a precatalyst. This complementary
protocol allowed the introduction of a greater diversity of substituents, including
those carrying sensitive functional groups. Mechanistic studies, including deuterium labelling, suggested that an alkenylrhodium
intermediate was produced during the course of the reaction. With a set of optimised
conditions, this species was successfully used in a tandem carbometallation–
conjugate addition (or annulation) reaction with bifunctional arylboron reagents. The
2-amidoindene products were obtained in good yields and high regioselectivities.Preliminary studies on the development of an asymmetric variant of this
transformation have been undertaken and the initial results have been reported. In addition, highly enantioselective dihydroxylation of the enamide substrates
prepared from the developed rhodium-catalysed carbometallations of ynamides was
readily accomplished using commercially available AD-mix- . This novel procedure
provides an access to a wide range of chiral products that might be difficult to access
using existing methods. Finally, as a further exemplification of asymmetric enamide
dihydroxylation, this method was applied to a concise total synthesis of the antifugal
natural product (+)-Tanikolide
REDUCTION OF THE VIBRATION-ROTATION-LAM HAMILTONIAN
No full textAuthor Institution: Department of Physics, Texas Tech UniversityThe vibration-rotation-LAM Hamiltonian requires two independent separation conditions to reduce the Coriolis interaction and the vibration-LAM kinetic energy interaction. In the limit of the LAM approaching a SAM, the effective vibration-rotation Hamiltonian and/or energy must reduce to the usual vibration-rotation Hamiltonian when no internal motion is a LAM. We show how to perform this reduction, especially as it relates to the T-and R-transformations and the normal coordinate transformation
Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
No full textAfter publication of this work [1], it has come to our attention
that there is an error in the author list of the initial
version of this manuscript; rather than Ernest J Lam,
the second author of the manuscript should be listed as
Ernest T Lam
Utility of novel diagnostic tests for tuberculosis using human urine
No full textIncludes abstract.Includes bibliographical references.Two thirds of new TB cases in sub-Saharan Africa are HIV coinfected. HIV-TB co-infection increases the incidence of extra-pulmonary, sputum smear-negative and sputum-scarce TB. In these vulnerable patientgroups with high mortality rates, sputum-based diagnostic tools are unhelpful. Urine-based diagnostics offer an attractive, easily available alternative for rapid diagnosis. We evaluated the point-of-care urine LAM strip test (Determine TB LAM Ag test, Alere) and urine-based Xpert MTB/RIF for TB diagnosis in two patient cohorts with high HIV prevalence. A spot urine sample was collected from two cohorts of persons with suspected TB. The first cohort consisted of ambulatory primary care clinic patients suspected of having TB (group 1) whilst the second comprised hospitalised patients with suspected HIV co-infection (group 2). The urine LAM ELISA, LAM strip test and Xpert MTB/RIF were performed according to the manufacturer’s instructions. In addition, the effects of using an alternative ‘rulein’ cut-point for the urine LAM strip test and a pelleted (2-10ml) urine sample for Xpert MTB/RIF testing on diagnostic accuracy and inter-reader reliability was assessed. The diagnostic reference standard was M. tuberculosis culture positivity
Supplementary Material, SupplementaryMaterial - Prenatal Growth Patterns and Birthweight Are Associated With Differential DNA Methylation and Gene Expression of Cardiometabolic Risk Genes in Human Placentas: A Discovery-Based Approach
No full text
Supplementary Material, SupplementaryMaterial for Prenatal Growth Patterns and Birthweight Are Associated With Differential DNA Methylation and Gene Expression of Cardiometabolic Risk Genes in Human Placentas: A Discovery-Based Approach by Pao-Yang Chen, Alison Chu, Wen-Wei Liao, Liudmilla Rubbi, Carla Janzen, Fei-Man Hsu, Shanthie Thamotharan, Amit Ganguly, Larry Lam, Dennis Montoya, Matteo Pellegrini, and Sherin U. Devaskar in Reproductive Sciences
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A comparative study of standard contract conditions for energy performance contracting in Australia, Canada and the United States
No full textAuthor name used in this publication: Lam, P.T.I.Author name used in this publication: Lee, P.2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishedPublisher permissio
Stiffness-force feedback in UAV tele-operation
No full textAerospace Design, Integration and OperationsAerospace Engineerin
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