117,484 research outputs found
Unraveling the genetics of fatty liver in obese children: additive effect of P446L GCKR and I148M PNPLA3 polymorphisms
No full text
Vitamin K concentration and cognitive status in elderly patients on anticoagulant therapy: a pilot study
No full textObjectives. Recent studies have suggested that vitamin K may exert significant effects on the central nervous system. The present study investigates the relationship between vitamin K plasmatic levels and cognitive functions in elderly patients on oral anticoagulant therapy (OAT). Design. At the Thrombosis Centre of Haematology, "Sapienza" University of Rome, 85 patients on OAT, aged between 75 and 92, were randomly enrolled in the study. Patients were on OAT with vitamin K antagonists (VKAs). Vitamin K1 concentrations were determined using standardized High-Performance Liquid Chromatography (HPLC). Cognitive functions were assessed using the Milan Overall Dementia Assessment (MODA). Results. MODA scores are positively correlated to vitamin K1 concentration. Patients with vitamin K1 below 0.100 μg/L and between 0.100 and 0.400 μg/L showed a mean MODA score of 79 ± 5 and 82 ± 3, respectively. Patients with vitamin K1 above 0.400 μg/L had a significantly greater MODA score (89 ± 1). After binning the data into bicentiles, MODA scores are shown to be linearly dependent on vitamin K1 concentrations (p<0.001). Even long-term OAT (>10 years) does not affect MODA scores. Education seems to exert a greater role on the cognitive status in comparison with aging. Conclusions. The study shows a positive association between vitamin K1 concentration and cognitive status in elderly patients (≥75 years) on OAT. The relationship between vitamin K1 concentration and MODA scores is described by a linear model. Cognitive status is not influenced by the duration of OAT but by the years of education. © 2020 Ludovico Alisi et al
"l BENEDETTINI NELLA VENEZIA GIULIA" DI ANTONIO ALISI
No full textAntonio Alisi je 1943. godine, povodom tisuéucetristote
obljetnice smrti sv. Benedikta iz Norcie, prikupio najvaznije vijesti
o samostanima benediktinskog reda u Julijskoj Krajini u dvije
rukopisne biljdnice koje se cuvaju u Diplomatskoj arhivi u Trstu.
S obzirom na vaznost tematike i na ulogu koju je imao taj crkveni
red u gospodarskoj proizvodnji, u ocuvanju klasicne kulture, u
preobrazbi krajolika putem melioracijskih radova i krcenjem
neplodnog zemljista, smatrali smo korisnim objaviti to djelo, uz
promjene i dodatke koji su proizisli tijekom istrazivanja, a koji su
opsirno dokumentirani u biljeskama.Nel 1943 Antonio Alisi, in ricorrenza del quattordicesimo centenario della
morte di S. Benedetto da Norcia, raccoglieva in due quaderni manoscritti conservati presso
l'Archivio Diplomatico di Trieste le notizie più importanti sui numerosi monasteri fondati
dall'Ordine benedettino nella Venezia Giulia. Vista l'importanza dell'argomento ed il
ruolo svolto dall'Ordine nella produzione economica, nella conservazione della cultura
classica, nella trasformazione del paesaggio attraverso le opere di bonifica e dissodamento
dei terreni, ci è parso opportuno pubblicare in trascrizione il manoscritto
Probiotics in Childhood Diseases: From Basic Science to Guidelines in 20 Years of Research and Development
No full textClinical evidence of the use of probiotics in pediatric NAFLD, framed within gut microbiota response, is herein discussed
Da Opuntia ficus-indica e Capsicum spp. prodotti sostenibili per i beni culturali. Il Programma Bilaterale Italia-Messico (2014-2020)
No full textQuesto volume è il frutto dell’attività svolta in ENEA sull’applicazione della mucillagine di Opuntia ficus-indica (fico d’india) e dell’estratto di frutti di Capsicum (peperoncino) nel settore dei beni culturali. L’applicazione di queste sostanze vegetali nel campo della conservazione è stata sviluppata all’interno di progetti finanziati dal Programma Esecutivo di Cooperazione Scientifica e Tecnologica tra l’Italia e gli Stati Uniti del Messico, promossi e finanziati dal Ministero per gli Affari Esteri e della Cooperazione Internazionale (MAECI). I due progetti, il primo con il titolo “Recupero di antiche tecnologie messicane per lo sviluppo di prodotti sostenibili per il restauro dei beni culturali” (2014-2017) e il secondo “Realizzazione di biomateriali per il restauro sostenibile dei beni culturali attraverso la valorizzazione di specie vegetali multifunzionali: Opuntia ficus-indica e Capsicum spp.”(2018-2020) sono stati sostenuti attraverso il cofinanziamento dei progetti “Grande Rilevanza” per lo svolgimento di attività congiunte con il partner messicano. In questo volume sono descritti i risultati ottenuti nel corso della realizzazione dei due progetti: si è messa a punto una metodologia estrattiva (con valutazione delle rese e delle caratteristiche dell’estratto ottenuto con diversi metodi) ed esplorate le procedure di stabilizzazione dei prodotti a base di mucillagine (NopalGel e NopalCap). Si è stabilito il range di concentrazione ottimale per l’utilizzo del NopalGel come additivo nelle malte, per il supporto dei dipinti murali, su malte idrauliche, su mattoni di terra cruda, sul supporto di una tela per dipinti, su carta moderna e su film di amido termoplastico. Prima di passare a prove in campo, si è verificata la biorecettività dei materiali trattati con NopalGel e NopalCap, per poterli applicare su beni storico-artistici e valutarne la capacità di ritardare l’attacco biologico. Sono quindi descritti i casi studio pionieri delle applicazioni dei prodotti NopalGel e NopalCap in interventi restauro
Hedgehog/hyaluronic acid interaction network in nonalcoholic fatty liver disease, fibrosis, and hepatocellular carcinoma
No full textThe I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-Alcoholic fatty liver disease
No full textThe aim of this secondary analysis of a randomized controlled trial was to test whether the I148M variant of Patatin-like phospholipase domain-containing protein-3 (PNPLA3) is associated with the response to docosahexaenoic acid (DHA) in children with non-Alcoholic fatty liver disease (NAFLD). Sixty children with NAFLD were randomized in equal numbers to DHA 250 mg/day, DHA 500 mg/day or placebo. Coherently with the primary analysis, the probability of more severe steatosis after 24 months of DHA supplementation was 50% lower [95% confidence interval (CI) -59% to -42%)] in the combined DHA 250 and 500 mg/day groups versus placebo. The present secondary analysis revealed an independent effect of PNPLA3 status on the response to DHA. In fact, the probability of more severe steatosis was higher (37%, 95% CI 26-48%) for the PNPLA3 M/M versus I/M genotype and lower (-12%, 95% CI -21% to -3%) for the I/I versus I/M genotype (Somers' D for repeated measures). We conclude that the 148M allele of PNPLA3 is associated with lower response, and the 148I allele with greater response, to DHA supplementation in children with NAFLD. © Copyright 2013, Mary Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2013
Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players?
No full textIntroduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH). It is clear that obesity is one of the main risk factors involved in NAFLD pathogenesis, even if specific mechanisms have yet to be elucidated. We investigated the distribution of intestinal bifidobacteria and lactobacilli in the stools of four groups of children: obese, obese with NAFL, obese with NASH, and healthy, age-matched controls (CTRLs). Material and methods: Sixty-one obese, NAFL and NASH children and 54 CTRLs were enrolled in the study. Anthropometric and metabolic parameters were measured for all subjects. All children with suspected NASH underwent liver biopsy. Bifidobacteria and lactobacilli were analysed in children’s faecal samples, during a broader, 16S rRNA-based pyrosequencing analysis of the gut microbiome. Results: Three Bifidobacterium spp. (Bifidobacterium longum, Bifidobacterium bifidum, and Bifidobacterium adolescentis) and five Lactobacillus spp. (L. zeae, L. vaginalis, L. brevis, L. ruminis, and L. mucosae) frequently recurred in metagenomic analyses. Lactobacillus spp. increased in NAFL, NASH, or obese children compared to CTRLs. Particularly, L. mucosae was significantly higher in obese (p = 0.02426), NAFLD (p = 0.01313) and NASH (p = 0.01079) than in CTRLs. In contrast, Bifidobacterium spp. were more abundant in CTRLs, suggesting a protective and beneficial role of these microorganisms against the aforementioned diseases. Conclusions: Bifidobacteria seem to have a protective role against the development of NAFLD and obesity, highlighting their possible use in developing novel, targeted and effective probiotics
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