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Conasprella (Boucheticonus) alisi
No full textConasprella (Boucheticonus) alisi (R̂ckel, Richard & Moolenbeek, 1995) Figs 2, 23–24 Conus alisi R̂ckel et al., 1995a: 579, figs 2, 4–5. Conus species no. 19 – R̂ckel et al. 1995b: pl. 72 figs 21–22. Boucheticonus alisi – Tucker & Tenorio 2013: 78. — Monnier et al. 2018a: 207. Material examined 211 lots (about 495 specimens). See Supp. file 1. Type material Holotype NEW CALEDONIA • 22.2 mm; Norfolk Ridge, Banc Aztèque, off New Caledonia, stn DW183; 23°18′ S, 168°05′ E; 330–367 m depth; 31 Jan. 1993; SMIB 8 expedition; MNHN-IM-2000-2588 (Fig. 23A). Figured material NEW CALEDONIA • 20.5 mm; Norfolk Ridge, Jumeau Ouest, off New Caledonia, stn CP3055; 23°42′ S, 168°01′ E; 250–320 m depth; 20 Oct. 2008; TERRASSES expedition; MNHN (Fig. 23B) • 27.7 mm; off N New Caledonia, stn DW926; 18º57′ S, 163º25′ E; 325–330 m depth; 7 Aug. 1994; BATHUS 4 expedition; MNHN (Fig. 23C) • 25 mm; off New Caledonia, stn DW230; 22º52′ S, 167º12′ E; 390–420 m depth; 30 Sep. 1985; MUSORSTOM 4 expedition; MNHN (Fig. 23D) • 20.3 mm; Norfolk Ridge, off New Caledonia, stn CP806; 23º42′ S, 168º01′ E; 308–312 m depth; 27 Nov. 1993; BATHUS 3 expedition; MNHN (Fig. 23E) • 18.7 mm; Norfolk Ridge, Banc P, off New Caledonia, stn DW1729; 23º20′ S, 168º16′ E; 340–619 m depth; 27 Jun. 2001; NORFOLK 1 expedition; MNHN (Fig. 23F) • 21.7 mm; same collection data as for preceding; MNHN (Fig. 23G) • 20.2 mm; same collection data as for preceding; MNHN (Fig. 23H) • 18 mm; Norfolk Ridge, Banc P, off New Caledonia, stn DW1728; 23º19′ S, 168º15′ E; 207–276 m depth; 27 Jun. 2001; NORFOLK 1 expedition; MNHN (Fig. 23I) • 19.1 mm; Norfolk Ridge, Banc P, off New Caledonia, stn DW1729; 23º20′ S, 168º16′ E; 340–619 m depth; 27 Jun. 2001; NORFOLK 1 expedition; MNHN (Fig. 23J) • 18 mm; Norfolk Ridge, Jumeau Ouest, off New Caledonia, stn DW3056; 23°42′ S, 168°01′ E; 250–330 m depth; 20 Oct. 2008; TERRASSES expedition; MNHN (Fig. 23K) • 20 mm; Norfolk Ridge, off New Caledonia, stn DW830; 23º20′ S, 168º01′ E; 361–365 m depth; 29 Nov. 1993; BATHUS 3 expedition; MNHN (Fig. 23L) • 19 mm; Grand Passage, off N New Caledonia, stn DW2964; 18º18′ S, 162º57′ E; 256–270 m depth; 02 May 2008; CONCALIS expedition; Atheris coll. (Fig. 23M). Geographical distribution and bathymetry New Caledonia: Norfolk Ridge and Grand Passage area, Loyalty Ridge and Coral Sea (Lansdowne Bank and Bellona Plateau), typically at depths between 200–500 m (Fig. 24). This species can be considered endemic. Remarks Conical shell small to moderately small (maximum length 30 mm), slightly pyriform. Protoconch (Fig. 23L) multispiral, pointed, of 4.5–5 whorls. Protoconch white with a peculiar brown blotch on fourth whorl. Spire slightly stepped, of moderate height, with a slightly convex outline. Radular tooth (Fig. 23M) large, very elongated with an extremely long anterior section that is more than four times as long as the posterior section of the tooth. Barb small and indistinct, with a blade that is enlarged and widened laterally. Serrations absent. Waist indistinct. Shaft fold not well developed but present. Slanted base with a large basal spur. This is one of the most abundant deep-water species of Conidae in New Caledonia. In spite of its large multispiral protoconch, the species can be considered endemic. It is highly variable in pattern and color. Pustulose specimens (Fig. 23I), with a somehow weird aspect, are not uncommon, but their identification is often confusing. In the phylogeny (Fig. 2), the specimens of C. alisi sequenced form a clade sister to Conasprella cf. pseudokimioi.Published as part of Tenorio, Manuel J. & Puillandre, Nicolas, 2023, Revision of the deep-water cone snail fauna from New Caledonia (Gastropoda, Conoidea), pp. 1-134 in European Journal of Taxonomy 896 on pages 34-36, DOI: 10.5852/ejt.2023.896.2291, http://zenodo.org/record/840551
ALISI - Application Laboratories of Institute of Scientific Instruments
No full textThe aim of ALISI is to establish and run well equipped regional R&D center developing diagnostic methods and technologies focused on microworld and nanoworld
Vitamin K concentration and cognitive status in elderly patients on anticoagulant therapy: a pilot study
Full text linkObjectives. Recent studies have suggested that vitamin K may exert significant effects on the central nervous system. The present study investigates the relationship between vitamin K plasmatic levels and cognitive functions in elderly patients on oral anticoagulant therapy (OAT). Design. At the Thrombosis Centre of Haematology, "Sapienza" University of Rome, 85 patients on OAT, aged between 75 and 92, were randomly enrolled in the study. Patients were on OAT with vitamin K antagonists (VKAs). Vitamin K1 concentrations were determined using standardized High-Performance Liquid Chromatography (HPLC). Cognitive functions were assessed using the Milan Overall Dementia Assessment (MODA). Results. MODA scores are positively correlated to vitamin K1 concentration. Patients with vitamin K1 below 0.100 μg/L and between 0.100 and 0.400 μg/L showed a mean MODA score of 79 ± 5 and 82 ± 3, respectively. Patients with vitamin K1 above 0.400 μg/L had a significantly greater MODA score (89 ± 1). After binning the data into bicentiles, MODA scores are shown to be linearly dependent on vitamin K1 concentrations (p<0.001). Even long-term OAT (>10 years) does not affect MODA scores. Education seems to exert a greater role on the cognitive status in comparison with aging. Conclusions. The study shows a positive association between vitamin K1 concentration and cognitive status in elderly patients (≥75 years) on OAT. The relationship between vitamin K1 concentration and MODA scores is described by a linear model. Cognitive status is not influenced by the duration of OAT but by the years of education. © 2020 Ludovico Alisi et al
Pre-natal and post-natal environment monitoring to prevent non-alcoholic fatty liver disease development
No full textEnhancing the Efficacy of Hepatocellular Carcinoma Chemotherapeutics with Natural Anticancer Agents
No full textRole of oxidative stress in the pathogenesis of cancer
No full textCarcinogenesis is a complex multi-step process
depending on several endogenous and exogenous
factors. A large number of evidences highlights the
important role of oxidative stress in cancer
development and progression. Oxidative stress
occurs as consequence of the cell accumulation of
reactive oxygen species (ROS) or reactive nitrogen
species (RNS). ROS and RNS are generated by
several different insults (i.e. UV light, inflammation,
air pollution, etc.). Physiologically, reactive oxygenmetabolites react with several bio-molecules such as lipids, nucleic acids and
proteins, but when their amount is excessively increased a permanent
structural and/or functional modification of the biological molecules may
occur. This mechanism represents the main way by which the products of
oxidative stress may induce carcinogenesis. On the other hand, since
oxidative stress is caused by an imbalance between the production of reactive
oxygen and cell ability to readily detoxify the reactive intermediates or easily
repair the resulting damage, another strategy to promote cancer is linked to
the less antioxidant capacity of an organism, too.
In this chapter we describe the role of oxidative stress in cancer
development and progression, focusing mainly our attention on the
mechanisms and molecules deregulated during oxidative damage, knowledge
that could be useful for improvement of anticancer gene therapy
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