1,721,064 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Investigation of the mechanisms of estrogen receptor activation by phosphorylation
Full text linkBreast cancer growth is estrogen- regulated in many cases. Estrogen actions
are mediated by estrogen receptors ERα and ERβ. Whilst the involvement of ERβ in
breast cancer is unresolved at present, up to 80% of breast tumours are ERα-
positive and likely to respond to endocrine therapies, such as anti-estrogens.
However, a substantial proportion of patients develop a resistance to such
treatments. Most resistant tumours continue to express ERα and many will respond
to an alternative hormonal therapy, indicating that ERα continues to be important
following the emergence of resistance. One proposed mechanism for endocrine
resistance is post-translational modification of the ERα, particularly phosphorylation
of ERα within the transcription activation domain AF1.
This project investigates how the phosphorylation at residues within the AF1
domain is linked to ERα activation and tumour cell growth in the presence of
tamoxifen and in the absence of ligand, by stable introduction of ERα
phosphorylation site mutants in the MCF7 human breast cancer cell line, commonly
used as a model for ERα-positive breast cancer. Characterisation of these lines
suggests that phosphorylation at the sites within the AF1 domain of the ER increases
the agonist activity of tamoxifen. Further studies to determine the mechanisms by
which ERα activity is regulated by phosphorylation within AF1 are discussed
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Cytidine Deaminases are Regulators of Estrogen Receptor Activity in Breast Cancer Cells
Full text linkBreast cancer is the most common cancer worldwide, with 1.38 million women
diagnosed with the disease each year. Estrogens play a critical role in the development
and progression of breast cancer, their action being mediated by the estrogen
receptors (ER), ERα and ERß, which are the members of the nuclear receptor
superfamily of transcription factors. This understanding has led to the development of
endocrine therapies aimed at inhibiting ER action by competitive binding to the ER
(anti-estrogens), or using inhibitors of estrogen biosynthesis (aromatase inhibitors).
Determining the mechanisms by which ER regulate gene expression will aid our
understanding of the role of ER in breast cancer progression, response and resistance
to endocrine therapies. Upon binding estrogen, ER drives the expression of estrogen
responsive genes through the orderly recruitment of co-regulators that act by
remodelling and modifying chromatin, ultimately promoting RNA polymerase II
recruitment and transcription initiation. Previous work from our laboratory has shown
that the APOBEC3B cytosine deaminase acts as an ERα transcriptional coactivator in
reporter gene assays. Here, I have developed these initial observations and
demonstrate that APOBEC3B is important for the regulation of estrogen responsive
genes and breast cancer cell growth. I show that APOBEC3B is recruited to the
promoters of estrogen-responsive genes and interacts with ERα. Studies carried out to
identify the molecular mechanisms by which APOBEC3B regulates the expression of
estrogen-responsive genes included its potential role in DNA demethylation and
identified a role for APOBEC3B in DNA strand break formation at the promoter of
the estrogen regulated pS2 gene. Together, these studies identify APOBEC3B as an
important new coregulator of ERα that is required for the regulation of gene
expression by estrogen in breast cancer cells
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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