5,625 research outputs found
Ali Curung Volatile Substance Abuse Management Plan
No full textThis plan has been developed in accordance with the provisions of the Volatile Substance Abuse Prevention Act (the Act) and represents the decision of residents and other interested persons of the community within the identified area management area, including the Ali Curung Community, Barkly Regional Council, Police and members of the public.
Association of N-terminal pro-brain natriuretic peptide with cognitive function and depression in elderly people with type 2 diabetes
No full text<p>Background: Type 2 diabetes mellitus is associated with risk of congestive heart failure (CHF), cognitive dysfunction and depression. CHF itself is linked both to poor cognition and depression. The ventricular N-terminal pro-brain natriuretic peptide (NT-proBNP) is a marker of CHF, suggesting potential as a marker for cognitive impairment and/or depression. This was tested in the Edinburgh Type 2 Diabetes Study (ET2DS).</p>
<p>Methodology and Principal Findings: Cross-sectional analysis of 1066 men and women aged 60–75 with type 2 diabetes. Results from seven neuropsychological tests were combined in a standardised general cognitive ability factor, ‘g’. A vocabulary-based test estimated pre-morbid cognitive ability. The Hospital Anxiety and Depression Scale (HADS) assessed possible depression. After adjustment for age and sex, raised plasma NT-proBNP was weakly associated with lower ‘g’ and higher depression scores (ß −0.09, 95% CI −0.13 to −0.03, p = 0.004 and ß 0.08, 95% CI 0.04 to 0.12, p<0.001, respectively). Comparing extreme quintiles of NT-proBNP, subjects in the highest quintile were more likely to have reduced cognitive ability (within the lowest tertile of ‘g’) and ‘possible’ depression (HADS depression ≥8) (OR 1.80; 95% CI: 1.20, 2.70; p = 0.005 and OR 2.18; 95% CI: 1.28, 3.71; p = 0.004, respectively). Associations persisted when pre-morbid ability was adjusted for, but as expected were no longer statistically significant following the adjustment for diabetes-related and vascular co-variates (β −0.02, 95% CI −0.07 to 0.03, p>0.05 for ‘g’; β 0.03, 95% CI −0.02 to 0.07, p>0.05 for depression scores).</p>
<p>Conclusion: Raised plasma NT-proBNP was weakly but statistically significantly associated with poorer cognitive function and depression. The prospective phases of the ET2DS will help determine whether or not NT-proBNP can be considered a risk marker for subsequent cognitive impairment and incident depression and whether it provides additional information over and above traditional risk factors for these conditions.</p>
NT-ProBNP Levels in Saliva and Its Clinical Relevance to Heart Failure
No full textBackground: Current blood based diagnostic assays to detect heart failure (HF) have large intra-individual and inter-individual variations which have made it difficult to determine whether the changes in the analyte levels reflect an actual change in disease activity. Human saliva mirrors the body's health and well being and ~20% of proteins that are present in blood are also found in saliva. Saliva has numerous advantages over blood as a diagnostic fluid which allows for a non-invasive, simple, and safe sample collection. The aim of our study was to develop an immunoassay to detect NT-proBNP in saliva and to determine if there is a correlation with blood levels. Methods: Saliva samples were collected from healthy volunteers (n = 40) who had no underlying heart conditions and HF patients (n = 45) at rest. Samples were stored at -80°C until analysis. A customised homogeneous sandwich AlphaLISA immunoassay was used to quantify NT-proBNP levels in saliva. Results: Our NT-proBNP immunoassay was validated against a commercial Roche assay on plasma samples collected from HF patients (n = 37) and the correlation was r = 0.78 (
Predicting growth rates of interfaces and internal layers in a turbulent boundary layer using a first order jump model
No full textExperimental research is presented on the characteristics of interfaces and internal layers that are present in a turbulent boundary layer (TBL). Both the turbulent non-turbulent interface (T/NT) and internal shear layers are detected in snapshots of the stereo-PIV data. It turns out that the internal layers exhibit similar characteristics compared to the T/NT interface. A theoretical approximation of the large scale boundary layer growth indicates that the correct boundary layer growth can be obtained by employing a modified first order jump model on the conditional statistics. Employing the same framework to the internal shear layers indicates that shear layers tend to move slower in close proximity to the wall, whereas they accelerate when moving away from the wall. Based on previous research it is believed that these internal layers separate large regions of approximately uniform momentum. Hence, boundary entrainment velocities may be interpreted as growth rates of large scale motions in a TBL
On Artin's braid group and polyconvexity in the calculus of variations
No full textLet Ω ⊂ 2 be a bounded Lipschitz domain and let
F : Ω × 2×2
+
−→
be a Carathèodory integrand such that F (x, ·) is polyconvex for L2-a.e. x ∈ Ω. Moreover assume that
F is bounded from below and satisfies the condition F (x, ξ) ∞ as det ξ 0 for L2-a.e. x ∈ Ω. The paper describes the effect of domain topology on the existence and multiplicity of strong local minimizers of the functional
[u] :=
Ω
F (x,∇u (x)) dx,
where the map u lies in the Sobolev space W1,p
id (Ω,2) with p 2 and satisfies the pointwise condition
det ∇u (x) > 0 for L2-a.e. x ∈ Ω. The question is settled by establishing that [·] admits a set of strong
local minimizers on W1,p id (Ω,2) that can be indexed by the group n ⊕ n, the direct sum of Artin’s pure braid group on n strings and n copies of the infinite cyclic group. The dependence on the domain topology is through the number of holes n in Ω and the different mechanisms that give rise to such local minimizers are fully exploited by this particular representation
An epistle to the author of The four farthing candles: By the author of The Rosciad of C-v-nt-G-rd-n.
No full text12p. ; 4⁰.The author of The Rosciad of C-v-nt-G-rd-n = Charles Churchill.With a half-title.Reproduction of original from the Huntington Library.English Short Title Catalog, ESTCN1512.Electronic data. Farmington Hills, Mich. : Thomson Gale, 2003. Page image (PNG). Digitized image of the microfilm version produced in Woodbridge, CT by Research Publications, 1982-2002 (later known as Primary Source Microfilm, an imprint of the Gale Group)
NT P1268 Dunmarra Thorium Grid Geodetic
No full textMaintenance and Update Frequency: notPlannedStatement: This NT P1268 Dunmarra Thorium Grid Geodetic is an airborne-derived radiometric thorium grid for the Dunmarra, NT, 2014. The survey was acquired under the project No. 1268 for the geological survey of NT. The grid has a cell size of 0.00083 degrees (approximately 91m). A total of 104017 line-kilometres of data at a line spacing of 400m and 80m terrain clearance were acquired to produce this grid. This radiometric thorium grid shows thorium element concentration of the Dunmarra, NT, 2014 in units of parts per million (or ppm). Noise-adjusted singular value decomposition (NASVD) has been applied to the data. NASVD is a spectral component analysis procedure for the removal of noise from gamma-ray spectra. Details of the specifications of individual airborne surveys can be found in the Fourteenth Edition of the Index of Airborne Geophysical Surveys (Percival, 2014). This Index is also available online at http://pid.geoscience.gov.au/dataset/79134.
Reference:
Percival, P.J., 2014. Index of airborne geophysical surveys (Fourteenth Edition).The radiometric, or gamma-ray spectrometric method, measures the natural variations in the gamma-rays detected near the Earth's surface as the result of the natural radioactive decay of potassium (K), uranium (U) and thorium (Th). The data collected are processed via standard methods to ensure the response recorded is that due only to the rocks in the ground. The results produce datasets that can be interpreted to reveal the geological structure of the sub-surface. The processed data is checked for quality by GA geophysicists to ensure that the final data released by GA are fit-for-purpose.<br/>This radiometric thorium grid has a cell size of 0.00083 degrees (approximately 91m) and shows thorium element concentration of the Dunmarra, NT, 2014 in units of parts per million (or ppm). The data used to produce this grid was acquired in 2014 by the NT Government, and consisted of 104017 line-kilometres of data at 400m line spacing and 80m terrain clearance
NT intervention and income quarantining
No full textLooking at both social and legal issues, this Brief considers the history associated with the NT intervention and income quarantining. By analysing past policy, the author concludes that it is the marginalised and disadvantaged who suffer most from punitive, disempowering measures such as income quarantining
Application of Recently Proposed Metaheuristics to the Sequence Dependent TSP
No full textThe Sequence Dependent Traveling Salesman Problem (SDTSP) is a combinatorial optimization problem defined as a generalization of the TSP. It emerged during optimization of two kinds of commonly used placement machines for production of printed circuit boards. The difference between SDTSP and TSP is that the cost incurred by transition from one point to another is dependent not only the distance between these points but also subsequent k points. In this study, we applied Simulated Annealing (SA), Artificial Bee Colony (ABC) and Migrating Birds Optimization (MBO) to solve real-world and random SDTSP instances. The metaheuristics were tested with 10 neighbor functions. In our computational study, we conducted extensive computational experiments. Firstly, we obtained best parameter value combination for each metaheuristic. Secondly, we conducted experiments so as to determine best performing neighbor function for each metaheuristic. Computational experiments show that twoopt function can be considered as the most suitable function for all the three metaheuristics
Diyabetik Nefropati Progresyonunda Nt-Pro BNP ve volüm yükü arasındaki ilişki
No full textObjectives: The early diagnosis of volume overload in chronic kidney disease (CKD) is very important. N-terminal probrain natriuretic peptide (NT-proBNP) is a valuable biomarker for this purpose. Our study aimed to detect the relationship
between NT-proBNP and left ventricular hypertrophy (LVH), hypertension (HT), GFR, and proteinuria among diabetic
patients with stage 3-4 CKD.
Methods: 160 diabetic patients with stage 3-4 CKD [80 patients in stage 3 CKD (group 1) and 80 patients in stage 4 CKD
(group 2)] were enrolled. NT-proBNP levels were evaluated in serum, and proteinuria was determined from 24-hour
collected urine. Left ventricular hypertrophy was evaluated by M-mode echocardiography. NT-proBNP levels were
compared according to their left ventricular hypertrophy, hypertension, and proteinuria levels.
Results: NT-proBNP levels was significantly higher, and GFR was lower in group 2 compared to group1 (p < 0.05). NTproBNP was higher in patients with LVH (+) HT (+) and proteinuria ≥ 1gr/d than patients with LVH (-), HT (-), and
proteinuria < 1g/d (p < 0.05). We found a significant correlation between NT-proBNP levels and left ventricular posterior
wall thickness, diastole (LVPWTd), proteinuria, SBP, and DBP. Proteinuria was the major contributor to increased NTproBNP levels among the independent variables.
Conclusion: We detected that NT-proBNP levels are increased during the progression of CKD, and proteinuria is the major
cause of increased NT-proBNP levels among the independent variables.Amaç: Kronik böbrek hastalığında (KBH) volüm yükünün erken tanısı çok önemlidir. NT- Pro BNP bunu gösteren değerli
bir biyomarkırdır. Çalışmamızda diyabetik nefropati zemininde KBH gelişen evre 3-4 hastalarda NT-Pro BNP'nin sol
ventrikül hipertrofisi, kan basıncı, glomerüler filtrasyon hızı ve proteinüri ile ilişkisini değerlendirmeyi amaçladık.
Yöntemler: Diyabetik nefropati zemininde kronik böbrek hastalığı gelişen evre 3, 80 hasta ile evre 4, 80 hasta çalışmaya
dahil edildi. NT-Pro BNP serumda, proteinüri 24 saatlik idrarda çalışıldı. Hastaların M-Mode ekokardiyografi ile sol
ventrikül hipertrofisi belirlendi. KBH evrelerine göre iki gruba ayrılan hastaların T Pro BNP değerleri, sol ventrikül
hipertrofisi, hipertansiyon ve proteinüri ile karşılaştırıldı.
Bulgular: Diyabetik nefropatide hastalığın progresyonu ile birlikte NT- Pro BNP anlamlı olarak artmaktaydı. Ancak NT Pro
BNP, sol ventrikül hipertrofisi, yüksek kan basıncı 1gram/gün üzerinde proteinürisi olanlarda daha yüksekti. Bununla
beraber NT- Pro BNP ile sol ventrikül duvar kalınlığı arasında da pozitif korelasyon vardı. Bağımsız değişken olarak
proteinüri, sistolik ve diyatolik kan basıncı NT- Pro BNP artışı ile ilişkilidir.
Sonuç: Kronik böbrek hastalığının progresyonu ile NT Pro BNP artmaktadır. Bu artışa en büyük katkıyı proteinüri
yapmaktadır
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