409 research outputs found
Diorganotin(IV) Complexes with Monohydrate Disodium Salt of Iminodiacetic Acid: Synthesis, Characterization, Crystal Structure and Biological Activities
No full textDiorganotin(IV) derivatives have been synthesized by the reaction of R 2 SnL 2 (R = n-Bu 1, Ph 2) with monohydrate disodium salt of iminodiacetic acid (Na 2 L) in 1:1 M/L ratio under reflux conditions. The compounds have been characterized by FT-IR, NMR ( 1 H and
13 C) spectoscopy, electron ionization mass spectrometry (EIMS), thermogravimetric analyses (TGA) and single crystal XRD. FTIR data indicates a mono-dentate binding mode of the carboxylic acid group as well as participation of the amino nitrogen and aqua oxygen in coordination with organotin(IV) moieties. NMR data demonstrates a tetra-coordinated environment around tin(IV) in solution. Mass spectrometric and thermogravimetric analyses verify the close similarities between the molecular structures of both complexes. The thermal stability of diphenyltin(IV) derivative (2) was found slightly higher than that of the free ligand (Na 2 L). Single crystal X-ray analysis of the complex 1 have shown a hexa-coordinated geometry around Sn(IV) with trans configuration. There are evidences for the existence of intermolecular hydrogen bonding in the structure of the complexes. The products displayed significant antibacterial and antifungal activities in contrast to the biologically inactive ligand precursor. However, the hemolytic cytoxicity of the complexes was comparatively high than the free ligand
sj-xlsx-1-smo-10.1177_20503121221148613 – Supplemental material for 25-Hydroxyvitamin-D deficiency in chronic kidney disease stages III, IV, and V in South Asian population: a retrospective cohort
No full textSupplemental material, sj-xlsx-1-smo-10.1177_20503121221148613 for 25-Hydroxyvitamin-D deficiency in chronic kidney disease stages III, IV, and V in South Asian population: a retrospective cohort by Muhammad Raheel Abdul Razzaque, Sameer Saleem Tebha, Alaa Tukruna, Aabiya Arif, Lucas Marian Kogut, Nasir Ali Afsar, Dania Shabbir and Zain Ali Zaidi in SAGE Open Medicine</p
Retraction note: Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of <em>Cinnamomum cassia</em> in Sprague-Dawley Rats (<em>Biological Trace Element Research</em>, (2018), 182, 1, (57-69), 10.1007/s12011-017-1074-3)
No full text\ua9 The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.The Editors-in-Chief have retracted this article after concerns were raised about data presented in Tables 2, 4, and 5 and error bars in Figs. 1, 2, 3, 12, 13, 14, and 15. The authors failed to provide raw data and evidence of ethical approval. The Editors-in-Chief therefore have lost confidence in the data presented in this article. Authors, Muhammad Shakeel, Farhat Jabeen, and Sadia Zafar do not agree to this retraction. Authors, Rehana Iqbal, Abdul Shakoor Chaudhry, Muhammad Ali, Muhammad Saleem Khan, Adeel Khalid, Samina Shabbir, and Muhammad Saleem Asghar have not responded to any correspondence from the editor/publisher about this retraction
The exegesis of Tabatabaei and the Hermeneutics of Hirsch: a comparative study
Get PDFThis thesis is a comparative study between Hermeneutics on the one hand and exegesis of the Holy Qur'an on the other. Its objective is to discover whether there are salient points of convergence between the two disciples, and whether issues germane to the Hermeneutical tradition in the West have been referred to and/or employed in Muslim works of Qur'an commentary. To this end, the works of one of the most prominent Shi'ite philosophers and exegetes. Allama Mohammad Hossein Tabataei, have been analysed and compared with the perspective and methodology of E D. Hirsch, one of the most important hermeneuticians in the Western World. Hirsch has been chosen since, in the opinion of the author, there is a considerable number of commonalities between the Hirschian approach to hermeneutics and the exegetical methodology of Tabatabaei and other Shi'ite Muslim interpreters of the Qur'an.. Hirsch, as an objectivist, along with a number of other Hermeneutical scholars, are critical of those who subscribe to philosophical Hermeneutics, such as Heideger and Gadimer. The same approach is taken in Tabatabaei's works, thus providing a strong rationale for an academic comparison of these two scholars. For this reason, this thesis attempts to study the theories of Tabatabaei and Hirsch in order to highlight the similarities and differences in their works. The central hypothesis is that while small differences in approach exist, there is much common ground, and that it is possible to use certain facets of Hirschian hermeneutics in the interpretation of the Qur'an, thus modernising some of the existing exegetical approaches employed by Shi'ite scholars.Since the aim of this thesis is to compare the interpretive works of Tabatabaei with those of Hirsch's, an introductory chapter has been dedicated to the study of the evolution of Shi'ite exegesis from the beginning to date. Tabatabaei's Al-Mizan has been chosen as the foremost work of Shi'ite exegesis in the modem period. Furthermore, a complete chapter has also been dedicated to Tabatabai's exegetical modus operandi as reflected in Al-Mizan, in order to arrive at a better understanding of his perspectives. This research arrives at the conclusion that philosophical Hermeneutics and Epistemology have opened new horizons on which we will always be dependent. Whatever interpretive theories with regards to the understanding of the text are accepted, or whatever the tendency as far as literary criticism is concerned, or whatever ideas are accepted in the arena of philosophy of human and social sciences, the discussion of the nature of understanding in general cannot be avoided. This does not mean that Hermeneutics is limited to these new theories. Rather, the opportunity always exists to introduce new interpretive theories in connection with the understanding of the text. It is indeed possible to study these discussions in detail in a separate sphere independent of the other branches of Islamic sciences and arrive at a number of stable principles in the interpretation of the text in Islamic research
Collected Papers (on Neutrosophics, Plithogenics, Hypersoft Set, Hypergraphs, and other topics), Volume X
Get PDFThis tenth volume of Collected Papers includes 86 papers in English and Spanish languages comprising 972 pages, written between 2014-2022 by the author alone or in collaboration with the following 105 co-authors (alphabetically ordered) from 26 countries: Abu Sufian, Ali Hassan, Ali Safaa Sadiq, Anirudha Ghosh, Assia Bakali, Atiqe Ur Rahman, Laura Bogdan, Willem K.M. Brauers, Erick González Caballero, Fausto Cavallaro, Gavrilă Calefariu, T. Chalapathi, Victor Christianto, Mihaela Colhon, Sergiu Boris Cononovici, Mamoni Dhar, Irfan Deli, Rebeca Escobar-Jara, Alexandru Gal, N. Gandotra, Sudipta Gayen, Vassilis C. Gerogiannis, Noel Batista Hernández, Hongnian Yu, Hongbo Wang, Mihaiela Iliescu, F. Nirmala Irudayam, Sripati Jha, Darjan Karabašević, T. Katican, Bakhtawar Ali Khan, Hina Khan, Volodymyr Krasnoholovets, R. Kiran Kumar, Manoranjan Kumar Singh, Ranjan Kumar, M. Lathamaheswari, Yasar Mahmood, Nivetha Martin, Adrian Mărgean, Octavian Melinte, Mingcong Deng, Marcel Migdalovici, Monika Moga, Sana Moin, Mohamed Abdel-Basset, Mohamed Elhoseny, Rehab Mohamed, Mohamed Talea, Kalyan Mondal, Muhammad Aslam, Muhammad Aslam Malik, Muhammad Ihsan, Muhammad Naveed Jafar, Muhammad Rayees Ahmad, Muhammad Saeed, Muhammad Saqlain, Muhammad Shabir, Mujahid Abbas, Mumtaz Ali, Radu I. Munteanu, Ghulam Murtaza, Munazza Naz, Tahsin Oner, Gabrijela Popović, Surapati Pramanik, R. Priya, S.P. Priyadharshini, Midha Qayyum, Quang-Thinh Bui, Shazia Rana, Akbara Rezaei, Jesús Estupiñán Ricardo, Rıdvan Sahin, Saeeda Mirvakili, Said Broumi, A. A. Salama, Flavius Aurelian Sârbu, Ganeshsree Selvachandran, Javid Shabbir, Shio Gai Quek, Son Hoang Le, Florentin Smarandache, Dragiša Stanujkić, S. Sudha, Taha Yasin Ozturk, Zaigham Tahir, The Houw Iong, Ayse Topal, Alptekin Ulutaș, Maikel Yelandi Leyva Vázquez, Rizha Vitania, Luige Vlădăreanu, Victor Vlădăreanu, Ștefan Vlăduțescu, J. Vimala, Dan Valeriu Voinea, Adem Yolcu, Yongfei Feng, Abd El-Nasser H. Zaied, Edmundas Kazimieras Zavadskas.
Collected Papers (on Neutrosophics, Plithogenics, Hypersoft Set, Hypergraphs, and other topics), Volume X
No full textThis tenth volume of Collected Papers includes 86 papers in English and Spanish languages comprising 972 pages, written between 2014-2022 by the author alone or in collaboration with the following 105 co-authors (alphabetically ordered) from 26 countries: Abu Sufian, Ali Hassan, Ali Safaa Sadiq, Anirudha Ghosh, Assia Bakali, Atiqe Ur Rahman, Laura Bogdan, Willem K.M. Brauers, Erick González Caballero, Fausto Cavallaro, Gavrilă Calefariu, T. Chalapathi, Victor Christianto, Mihaela Colhon, Sergiu Boris Cononovici, Mamoni Dhar, Irfan Deli, Rebeca Escobar-Jara, Alexandru Gal, N. Gandotra, Sudipta Gayen, Vassilis C. Gerogiannis, Noel Batista Hernández, Hongnian Yu, Hongbo Wang, Mihaiela Iliescu, F. Nirmala Irudayam, Sripati Jha, Darjan Karabašević, T. Katican, Bakhtawar Ali Khan, Hina Khan, Volodymyr Krasnoholovets, R. Kiran Kumar, Manoranjan Kumar Singh, Ranjan Kumar, M. Lathamaheswari, Yasar Mahmood, Nivetha Martin, Adrian Mărgean, Octavian Melinte, Mingcong Deng, Marcel Migdalovici, Monika Moga, Sana Moin, Mohamed Abdel-Basset, Mohamed Elhoseny, Rehab Mohamed, Mohamed Talea, Kalyan Mondal, Muhammad Aslam, Muhammad Aslam Malik, Muhammad Ihsan, Muhammad Naveed Jafar, Muhammad Rayees Ahmad, Muhammad Saeed, Muhammad Saqlain, Muhammad Shabir, Mujahid Abbas, Mumtaz Ali, Radu I. Munteanu, Ghulam Murtaza, Munazza Naz, Tahsin Oner, Gabrijela Popović, Surapati Pramanik, R. Priya, S.P. Priyadharshini, Midha Qayyum, Quang-Thinh Bui, Shazia Rana, Akbara Rezaei, Jesús Estupiñán Ricardo, Rıdvan Sahin, Saeeda Mirvakili, Said Broumi, A. A. Salama, Flavius Aurelian Sârbu, Ganeshsree Selvachandran, Javid Shabbir, Shio Gai Quek, Son Hoang Le, Florentin Smarandache, Dragiša Stanujkić, S. Sudha, Taha Yasin Ozturk, Zaigham Tahir, The Houw Iong, Ayse Topal, Alptekin Ulutaș, Maikel Yelandi Leyva Vázquez, Rizha Vitania, Luige Vlădăreanu, Victor Vlădăreanu, Ștefan Vlăduțescu, J. Vimala, Dan Valeriu Voinea, Adem Yolcu, Yongfei Feng, Abd El-Nasser H. Zaied, Edmundas Kazimieras Zavadskas.
Proposal for a New Economic Framework Based On Islamic Principles
Get PDFThis book provides a holistic socio-economic framework working in conformity with the Islamic principles. Chapter 2 builds the ground for the proposed framework by discussing the foundations of the ethical precepts of Islam. It discusses the thesis of religion, answers some of the questions in the comparative study of religion and tries to resolve few of the misconceptions about the faith of Islam. Chapter 3 outlines the economic teachings of Islam with regard to earning and spending. It discusses at length the ideals Islam set before its adherents in the ethical sphere of life. The ethical principles are discussed based on the study of relevant Quranic text and the narrations of Prophet Muhammad (PBUH). Chapter 4 studies the comparative economic systems. It analyzes Capitalism, Socialism, Mixed Economy and Islamic economic system. Chapter 5 introduces the salient features of the proposed economic framework with special focus on fiscal reforms. It discusses the potential of the institution of Zakat to meet fiscal needs of the government and to assist it in doing away with deficit financing, fiscal bleeding, crowding out private sector and reducing deadweight loss by parting the way with private sector so as to ensure market economy operating on its own as far as possible and playing an active regulatory role. Chapter 6 introduces the monetary reforms. It discusses how savings would feature despite discontinuation of interest, how inflation will be checked with central banks not having at their disposal conventional OMO, how liquidity will be managed in banking sector when a central bank wants to inject liquidity or mop up funds. How and to what extent the institution of Zakat would enable the government to meet its fiscal targets and does not crowd out private sector with public borrowing. How balance of payments and exchange rate stability can be managed in an interest free economy. If in the short term, the government or central bank needs alternative source of revenue other than Zakat, they can issue GDP linked bonds. This could replace T-bill and provide a base instrument for OMO and liquidity management in the banking and financial sector. Chapter 7 introduces the currently practiced Islamic Banking and Finance. Since Islamic economic principles have more prominently been used in banking and finance, much of the discussion centers on Islamic banking and finance in lieu of analyzing the existing practices and then in the next chapter, preferable alternatives in areas where shortcoming is observed and need for improvement is felt are suggested. Chapter 8 discusses the financial system in the proposed framework with the role of institutions and the discussion on comprehensive need fulfillment mechanisms to serve every major need of a sophisticated contemporary financial system. Some important novel changes are recommended, such as introduction of options in mortgage financing, which will allow the bank to separate the tenancy and sale contract in a distinctive way. This will still ensure that it locks the sale with the borrower or with the third party without making both contracts dependent on each other. It will benefit the bank as well as the borrower, who will have an option but not an obligation to buy the asset at maturity. The modified role of bank entering in a Mudarabah contract as a “Rabb-ul-maal” (investor) will ensure that the bank takes on operational risk. It will enable the resources to go into productive avenues rather than in financial instruments. This modification will generate employment and productive activities in the economy in a more direct manner. The division of Mudarabah corporate and Mudarabah consumer will target two very distinct markets and will result in channeling of funds from saving surplus units to saving-deficient units. Reforms in equity markets and alternatives for insurance are also suggested. Chapter 9 introduces feasibility and structure of Micro credit as an alternative for interest based micro finance. It discusses how the potential obstacles in the form of lack of trust, funding commitment, lack of collateral arrangement, lack of documentation etc would be handled.Interest Free Economy, Islamic Economy, Islamic Economic System, Islamic Monetary Policy, Islamic Fiscal Policy, Interest, Zakat, Riba, Usury, Development, Redistribution, Economic Systems, Financial System, Financial Intermediation, Saving, Investment.
Tyrosinase (TYR) gene sequencing and literature review reveals recurrent mutations and multiple population founder gene mutations as causative of oculocutaneous albinism (OCA) in Pakistani families
No full textPurposeTo investigate eight previously unreported Pakistani families with genetically undefined OCA for mutations in TYR.MethodsSanger sequencing of TYR has been performed in eight families with OCA phenotype. Mutation analysis was performed to establish the pathogenic role of novel mutation. Bioinformatics analysis was performed to predict the structural and functional impacts on protein due to the mutation.ResultsIn this study, we identified six likely pathogenic variants of TYR (c.272 G>A, c.308 G>A, c.346C>T, c.715 C>T, c.832 C>T and c.1255 G>A), including one novel variant (c.308 G>A; p.Cys103Tyr), segregating as appropriate in each family. Cys103 lies in the highly conserved region of the tyrosinase enzyme, and p.Cys103Tyr is predicted to disturb enzymatic function via alteration of the configurational orientation of TYR leading to a more rigid polypeptide structure. We have also reviewed the mutation spectrum of TYR in Pakistani ethnicity. Published data on OCA families proposed that ~40% have been associated with genetic variations in the TYR gene. The mutations reported in this study have now been described with varying frequencies in Pakistani families, including very rare/unique mutations.ConclusionA literature review of TYR gene mutations in Pakistani populations, combined with our genetic data, identified a number of gene mutations likely to represent regional ancestral founder mutations of relevance to Pakistani populations, in addition to sporadic and recurrent ‘hotspot’ mutations present repeatedly in other regions worldwide.</p
Renewable and nonrenewable energy consumption, real GDP and CO2 emissions nexus: a structural VAR approach in Pakistan
Get PDFAny rise in real GDP crafts higher energy demand in Pakistan. This short-term rising energy requirement is fulfilled with the help of nonrenewable and renewable energy consumption, but nonrenewable energy consumption adds more in it. The rise in nonrenewable energy consumption lifts real GDP up in short-run. Forecast error variance decomposition illustrates nonrenewable energy consumption alone passes 87% variation in the CO2 emissions. This verifies fossil fuels are accountable for environmental degradation in Pakistan. The CO2 emissions worsen economic activity, real GDP falls but renewable energy consumption augments. This elevation in renewable energy consumption is the proof of stabilization efforts that are being initiated by official authorities as CO2 emissions reach to alarming level. The rise in renewable energy consumption boosts economic activity, and real GDP breeds. Most of times, an increase in renewable energy consumption is an effort to substitute it with nonrenewable energy consumption, resulting in lower level of CO2 emissions.Energy Consumption, Real GDP, CO2 Emissions
Incidence of Nephropathy After Spontaneous Bacterial Peritonitis in Decompensated Liver Cirrhosis at Muhammad Teaching Hospital, Peshawar: A Single Institution Descriptive Cross-Sectional Study
Get PDFObjective: To determine the incidence of nephropathy after spontaneous bacterial peritonitis in patients with
decompensated liver cirrhosis.
Study Design: Descriptive cross-sectional study.
Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad Teaching
Hospital (MTH), Peshawar, Pakistan from November 1st, 2024, to April 30th 2025.
Methods: A total of one hundred and ten (110) patients were part of the current study. This sample size was
obtained by using the WHO sample size calculator, for which a reference study was considered having a
frequency of renal impairment in about 83.3% of patients who had developed decompensated liver cirrhosis
followed by spontaneous bacterial peritonitis. Consecutive, non-probability sampling technique was used. The
confidence interval was equal to 95% while error margin was equal to 6% to calculate the size.
Results: Participants of the study were adults, and the minimum age was 18, whereas the oldest was 60 years,
with a mean of 46.436 ± 6.81 years. As chronic liver disease patients were selected, they had a prolonged
history of decompensated cirrhosis of the liver (mean duration was 8.845 ± 2.38 months). Gender classification
of 110 participants was done, in which males were 91 (82.7%) and females were 19 (17.3%). Nephropathy
(Renal impairment) was observed in 33 (30%) of patients after spontaneous bacterial peritonitis in
decompensated liver cirrhosis.
Conclusion: In this study, the results showed that overall, there was 30% renal impairment in the observed
cases. They were more prominent in Child's Pugh C cirrhosis liver compared to Class A or B cirrhosis liver
because of the development of ascites.
How to cite this: Alam S, Ayaz M, Kausar SAZ, Ullah R, Imran A, Khan MS. Incidence of Nephropathy After Spontaneous Bacterial Peritonitis in Decompensated Liver Cirrhosis at Muhammad Teaching Hospital, Peshawar: A Single Institution Descriptive Cross-Sectional Study. Life and Science. 2025; 6(3): 356-361. doi: http://doi.org/10.37185/LnS.1.1.94
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