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Ali Husain Mir Interview
No full textAli Husain Mir is a Bollywood lyricist and script writer and a professor of Management at William Paterson University. Mir visited the Hindi Urdu Flagship at the University of Texas at Austin to speak to Flagship students about his career in Urdu literature and Bollywood production. For this interview, Mir sat down with HUF directors, Syed Akbar Hyder and Herman van Olphen, to discuss his background in Urdu and the state of the language in modern India. Mir is the author of Anthems of Resistance, the definitive book on the All India Progressive Writers’ Movement; he is also an acclaimed lyricist and script-writer for Hindi and Urdu films (Iqbal, Dor). Mir’s oeuvre engages issues of religious minorities and secularism in South Asia.Asian Studie
Role and regulation of miR-483 in cancer
No full textThe hsa-mir-483 locus is located at chromosome 11p15.5 within intron 2 of the IGF2 locus. Because of its location, de-regulated in Wilms’ tumor and other neoplasia, I hypothesized that this microRNA had a potential role in tumors. By analyzing 19 Wilms’ tumors, I proved that miR-483-3p is indeed over-expressed in 100% of the cases and a co-regulation with the over-expression of IGF2 was found.
However, several other types of common adult cancers exhibit high or even extremely high levels of miR-483-3p expression without IGF2 over-expression. Indeed, independently from IGF2, the expression of the miR-483-3p could also be induced by the oncoprotein β-catenin through a novel interaction with the basic Helix-Loop-Helix protein upstream stimulatory transcription factor 1 (USF1).
I also show that β-catenin itself is a target of miR-483-3p, triggering a negative regulative loop that becomes ineffective in cells harbouring activating mutations of β-catenin pathway.
The potential oncogenic role of miR-483-3p was supported by the findings that its ectopic expression protects cells from apoptosis and, conversely, its inhibition increase the level of apoptosis. To understand the mechanisms of its action, I investigated potential gene targets. Among these, an important pro-apoptotic protein, Puma, were inhibited by miR-483-3p. My results indicate that miR-483-3p functions as an anti-apoptotic oncogene, coordinately over-expressed with IGF2 in Wilms’ tumors or induced by β-catenin activation in other tumor types
miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression.
No full textAcquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide. All these chemotherapies have in common that they are administered sequentially and often result in chemoresistance. Here, we mimicked this pulse therapy of breast cancer patients in an in vitro cell culture model, where the epithelial breast cancer cell line BT474 was sequentially treated with doxorubicin for several treatment cycles. In consequence, we obtained chemoresistant cells displaying a mesenchymal-like phenotype with decreased levels of miR-200c. To investigate the involvement of miR-200c in resistance formation, we inhibited and overexpressed miR-200c in different cell lines. Thereby, the cells were rendered more resistant or susceptible to doxorubicin treatment. Moreover, the receptor tyrosine kinase TrkB and the transcriptional repressor Bmi1 were identified as miR-200c targets mediating the drug resistance. Hence, we provide a mechanism of acquired resistance to doxorubicin that is caused by the loss of miR-200c. Along with this, our study demonstrates the complex network of microRNA mediated chemoresistance highlighting the challenges in cancer therapy and the importance of novel microRNA-modulating anticancer agents
Ali B. Al-Hasan B. Ja?dawayh's Kitab Mir'?t Al-Muruww?t (analysis and translation)
No full textYÖK Tez No: 607545ÖZET ALİ B. EL-HASAN B. CA?DEVEYH'İN KİTÂBU MİR'ÂTİ'L-MÜRÜVVÂT'I (TAHLİL VE TERCÜME) TAŞTAN, Arife Yüksek Lisans, Tarih Anabilim Dalı Tez Danışmanı: Doç. Dr. Ali ERTUĞRUL Aralık 2019, XI + 315 sayfa Muhaddis Ali b. el-Hasan b. Muhammed b. Ca?deveyh er-Râzî el-Kazvînî'ye ait olan Kitâbu Mir'âti'l-mürüvvât isimli Arapça eser, Süleymaniye Kütüphanesi Ayasaofya Bölümü 2049 numaralı Mecmu'adaki yazma nüshası (v. 35a-77b) üzerinden İhsan Zünnûn es-Sâmirî ve Hulûd bint Muhammed el-Ahmedî tarafından tahkik edilip 2014 yılında neşredilmiş, ancak bugüne kadar Türkçeye tercüme edilmemiştir. İbn Ca?deveyh tarafından Büyük Selçuklu veziri Nizâmülmülk'e ithaf edilen bu eser, geçmişte Franz Taeschner ve Abdülbaki Gölpınarlı gibi araştırmacıların ilgisini çekmiştir. Alman şarkiyatçı Taeschner, eserin fütüvvetin esaslarını anlatan kırkıncı babını Almancaya tercüme ederek aslı ile birlikte neşretmiştir. Abdülbâki Gölpınarlı ise Ayasofya 2049 numaralı Mecmu'anın tanıtımını yaptığı sırada İbn Ca?deveyh'in bu eserinden de bahsetmiş, içindekiler bölümünün tercümesini yaparak liste halinde vermiştir. Kitâbu Mir'âti'l-mürüvvât, ağırlıklı olarak, İslam öncesi dönemde de önem arz eden ahlâkî kavramlardan mürüvvet ve fütüvvetle ilgilidir. Kendisinden önce yazılmış olan mürüvvetle ilgili eserlerin bir devamı niteliğinde olup fütüvvetle ilgili yazılmış eserlerin ilklerinden olma özelliğine sahiptir. Bu yönüyle tasavvufî fütüvvet döneminde mürüvvet ve fütüvvetin esaslarını anlatmak üzere yazılmıştır ve mürüvvetten fütüvvete geçiş aşamasının karakteristik özelliklerini bünyesinde taşır. Muhtevasının bir kısmı Seâlibî'nin Mir'âtü'l-mürûat'ıyla benzerlik gösterir. Bu çalışmada, bir hutbe, bir mukaddime ve kırk bir babtan oluşan Kitâbu Mir'âti'l-mürüvvât tercüme edilerek verilmiştir. Henüz tam bir biyografisi yazılmamış olan İbn Ca?deveyh'in hayatı işlenmiş ve eseri muhtelif açılardan ele alınıp tahlil edilmiştir. Ayrıca dönemin diğer benzer eserleri arasındaki yeri tayin edilmeye çalışılmıştır.ABSTRACT ALİ B. AL-HASAN B. JA'DAWAYH'S KİTAB MİR'?T AL-MURUVV?T (ANALYSIS AND TRANSLATION) TAŞTAN, Arife Master's Degree, Department of History Thesis Advisor: Doç. Dr. Ali ERTUĞRUL December 2019, XI + 315 pages The arabic work named as Mir'?t al-muruvv?t that is belong to Muhaddith 'Ali b. al-Hasan b. Muhammed b. Ja?dawayh al-R?z? al-Kazvin?, was verified and published in 2014 by Ihsan Zünn?n es-S?mir? and Hul?d b. Muhammed al-Ahmad? through the manuscript (v. 35a-77b) in the journal 2049 of the Ayasaofya (Hagia Sophia) Department of the Süleymaniye Library, but it has not been translated into Turkish until today. This work that dedicated to vizier of the Grand Seljuk Nizam al-Mulk by Ibn Ja?dawayh, has attracted the attention of researchers such as Franz Taeschner and Abdülbaki Gölpınarlı. The German Orientalist Taeschner translated its fortieth chapter into German, explaining the principles of futuvvah. Abdülbâki Gölpınarlı also mentioned the work of Ibn Ja?dawayh during the review of the magazine numbered 2049 in Ayasaofya and translated the contents section and gave a list. The Kitâbu Mir'?t al-muruvv?t mainly concerned with the moral concepts of muruvvah and futuvvah, which are important in the pre-Islamic period. That is a continuation of the works of muruvvah written before it and is one of the first of the works written about futuvvah. In this aspect it is written to describe the principles of muruvvah and futuvvah in the sufistic futuvvah period and also it has the characteristic features of the transition stage from muruvvah to futuvvah. Some of its content is similar to that of Mir'?t al-mur?at of Se?lib?. In this work, Kit?bu Mir'?t al-muruvv?t, which consists of a khutbah, a muqaddimah and forty one chapters, has been translated. The life of Ibn Ja?dawayh, whose biography has not yet been written, has been processed and his work has been analyzed from various angles. In addition, it was tried to determine the place among other similar works of the period
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Romance and Revolution in Bollywood Songs: Politics, Language, and Religion in Hindi-Urdu Cinema
No full textAli Husain Mir is a Bollywood lyricist and script writer and a professor of Management at William Paterson University. Mir visited the Hindi Urdu Flagship at the University of Texas at Austin to speak to Flagship students about his career in Bollywood production and the changing role of Urdu in Indian cinema.
Mir is the author of Anthems of Resistance, the definitive book on the All India Progressive Writers’ Movement; he is also an acclaimed lyricist and script-writer for Hindi and Urdu films (Iqbal, Dor). Mir’s oeuvre engages issues of religious minorities and secularism in South Asia.Asian Studie
Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway
No full textBackground: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths, reflecting the aggressiveness of this type of cancer and the absence of effective therapeutic regimens. MicroRNAs have been involved in the pathogenesis of different types of cancers, including liver cancer. Our aim was to identify microRNAs that have both functional and clinical relevance in HCC and examine their downstream signaling effectors. Methods: MicroRNA and gene expression levels were measured by quantitative real-time PCR in HCC tumors and controls. A TargetScan algorithm was used to identify miR-9 downstream direct targets. Results: A high-throughput screen of the human microRNAome revealed 28 microRNAs as regulators of liver cancer cell invasiveness. MiR-9, miR-21 and miR-224 were the top inducers of HCC invasiveness and also their expression was increased in HCC relative to control liver tissues. Integration of the microRNA screen and expression data revealed miR-9 as the top microRNA, having both functional and clinical significance. MiR-9 levels correlated with HCC tumor stage and miR-9 overexpression induced SNU-449 and HepG2 cell growth, invasiveness and their ability to form colonies in soft agar. Bioinformatics and 3’UTR luciferase analyses identified E-cadherin (CDH1) and peroxisome proliferator-activated receptor alpha (PPARA) as direct downstream effectors of miR-9 activity. Inhibition of PPARA suppressed CDH1 mRNA levels, suggesting that miR-9 regulates CDH1 expression directly through binding in its 3’UTR and indirectly through PPARA. On the other hand, miR-9 inhibition of overexpression suppressed HCC tumorigenicity and invasiveness. PPARA and CDH1 mRNA levels were decreased in HCC relative to controls and were inversely correlated with miR-9 levels. Conclusions: Taken together, this study revealed the involvement of the miR-9/PPARA/CDH1 signaling pathway in HCC oncogenesis
Lived Experiences of Islamic High School Graduates in The Chicagoland Area: A Phenomenological Study
No full textIslamic high schools have existed in the Chicagoland area for a number of years. There has been no study studying the impact of the schools on the lives of graduates. The purpose of this study was to describe, analyze, and reflect on lived experiences of graduates of Islamic high schools in the Chicagoland area. The aim of this study was to give a voice to students who lived the experience of attending and graduating from an Islamic high school in the Chicagoland area. This qualitative phenomenological study focused on the experiences of six graduates from three Islamic high schools in the Chicagoland area of the U.S. The graduates were asked about their general experiences and also asked about some of the challenges students faced in college in terms of identity, drugs, alcohol, pre-marital physical relationships, and Islamophobia. Based on the analysis of the responses of the graduates revealed four themes to include life-long lessons learned; life-long relationships developed; students who felt academically prepared, but socially unprepared; and schools that overprotected the students. Based on the results, recommendations were provided and legal, political, internal, and external implications of the study assessed.|Keywords: Islamic schools, graduates, dissertationProQuest Traditional Publishing Optio
Towards Optimal Deployment of a Sensor Network in a 3D Indoor Environment for the Mobility of People with Disabilities (Short Paper)
No full textMobility of people with disabilities is one of the most important challenges for their social integration. There have been significant effort to develop assistive technologies to guide the PWD during their mobility in recent years. However, these technologies have limitations when it comes to the navigation and guidance of these people through accessible routes. This is specifically problematic in indoor environments where detection, location and tracking of people, and other dynamic objects that may limit the mobility of these people, are very challenging. Thus, many researches have leveraged the use of sensors to track users and dynamic objects in indoor environments. However, in most of the described methods, the sensors are manually deployed. Due to the complexity of indoor environments, the diversity of sensors and their sensing models, as well as the diversity of the profiles of people with disabilities and their needs during their mobility, the optimal deployment of a sensor network is a challenging task. There exist several optimization methods to maximize coverage and minimize the number of sensors while maintaining the minimum connectivity between the sensor nodes in a network. Most of the current sensor network optimization methods oversimplify the environment and do not consider the complexity of 3D indoor environments. In this paper, we propose a novel 3D local optimization algorithm based on a geometric spatial data structure that takes into account some of these complexities for the purpose of helping PWD in their mobility in 3D indoor environments such as shopping centers, museums and other public buildings
Aspects of Mir Sher Ali Afsos’s Poetry
No full textMir sher Ali Afsos was a successful ghazal poet of his era. He has tried almost all the popular genres of speech. The poetry of Mir Sher Ali Afsos seems to be impressive in the color of despair apart from love, but this color is traditional. A study of Kuliat-e-Afsos reveals that he has used all the essentials of art to enhance the reader's quest for techniques, similes and metaphors in his words, as well as the craft of poetry. Afsos has also used beautiful arts in his speech, all these accessories create a charming beauty in the poetry which makes the poet beautiful. His poetry is romantic. In this article effort is made to analyse his poetry
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