184 research outputs found
Polymer-coated superparamagnetic iron oxide nanoparticles as T2 contrast agent for MRI and their uptake in liver
No full textAim: To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T2 magnetic resonance contrast agent and their uptake and toxicity in liver. Materials & methods: Mice were intravenously injected with bioferrofluids and Endorem®. The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques. Results: Bioferrofluids are a good T2 contrast agent with a higher r2/r1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection. Conclusion: Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection
The Spousal Abuse in Mary Wollstonecraft's The Wrongs of Woman, or Maria
No full textAbstract: The spousal abuse is a form of abusive and aggressive actions that woman encounters in her close relationship with her male partner who attempts to uphold control and power over his spouse. This subject has increased widely nowadays and it needs to be investigated through the lens of literature in order to give a voice for the voiceless wives who endure the bad temper and abuse of their spouses. It will be studied in The Wrongs of Woman which is considered as a feminist novel and one of the best 18th century novels. Wollstonecraft’s philosophical and gothic tale tells the story of Her husband has committed her to an insane asylum. It critiques the oppressive sacredness of getting married in eighteenth-century Britain, and also the judicial framework that upholds it, according to Wollstonecraft., and focuses on society rather than individual female wrongdoings. The purpose of this dissertation is to utilize a thematic method to evaluate the theme of spousal abuse of women in the novel, and to investigate the impact and consequences on the main female characters. Her novel , was designed to be read and appreciated as both profoundly restorative and historical important in terms of what that exposes concerning patriarchal and patriarchal systems’ effects on women’s lives.
Keywords: Spouse Abuse, Maria, or the Wrongs of Woman, Offending Theory, Mary Wollstonecraft.
Title: The Spousal Abuse in Mary Wollstonecraft’s The Wrongs of Woman, or Maria
Author: Prof. Lamiaa Ahmed Rasheed, Maryam Kazim Mohammed
International Journal of Recent Research in Social Sciences and Humanities (IJRRSSH)
ISSN 2349-7831
Vol. 9, Issue 4, October 2022 - December 2022
Page No: 147-152
Paper Publications
Website: www.paperpublications.org
Published Date: 08-December-2022
DOI: https://doi.org/10.5281/zenodo.7413493
Paper Download Link (Source)
https://www.paperpublications.org/upload/book/The%20Spousal%20Abuse%20in%20Mary%20Wollstonecraft’s-08122022-1.pdfInternational Journal of Recent Research in Social Sciences and Humanities (IJRRSSH), ISSN 2349-7831, Paper Publications, Website: www.paperpublications.or
A Ten-Year-Old with Rash and Fever: Atypical Presentation of Kawasaki Disease
No full textINTRODUCTION: Kawasaki Disease is the leading cause of acquired heart disease in young children in the US. The exact cause of Kawasaki Disease remains unknown; however, a combination of clinical symptoms, including fever, conjunctival congestion, cervical lymphadenopathy, and changes in oral cavity and peripheral extremities, confirm the diagnosis.
CASE DESCRIPTION: A ten-year-old, ill-appearing Latina female presented to her primary pediatrician with a swollen face, left-sided subconjunctival hemorrhage, and mild erythematous rash on both arms and legs. Three days prior to presentation, she was seen at an ED due to emesis, abdominal pain, a painful pruritic erythematous rash on her hands, and an erythematous, blanching, maculopapular rash diffusely across her body. At that time, her conjunctivas were clear and her posterior pharynx was erythematous without exudates. A Rapid Strep A Screen administered at the ED was negative. While at the pediatrician’s clinic, another Rapid Strep test was conducted and remained negative. A urine analysis indicated large bilirubin and ketones with trace blood, protein and leukocytes. The patient was admitted to the pediatric inpatient service.
The patient remained in the hospital for five days, and remained febrile for four days with a maximum temperature of 102°F. During admission, labs demonstrated an elevated ESR and CRP . She was treated with doxycycline for suspected tick-borne illness, pending additional lab results, and sent home.
The patient returned to the clinic three days post-discharge reporting nausea and vomiting. The family reported her having a purple/blue tongue two days prior. On physical exam, she had a strawberry-like tongue and a desquamating rash on her palms, soles and peri-inguinal area. She was once again readmitted where her labs showed transaminitis, elevated CRP and ESR, and thrombocytosis. An echocardiogram indicated no abnormalities. Based on prior medical history, a presumptive diagnosis of Kawasaki Disease was made. The patient was treated with IVIG and 81mg ASA daily which was successful.
DISCUSSION: This case demonstrates a rare presentation of Kawasaki Disease, with 11 days of symptoms until clinic diagnosis. This diagnosis requires purposeful questioning, along with clinical, and lab findings. Recognition of this syndrome is critical due to its potential to cause fatal coronary artery aneurysms. After appropriate treatment with IVIG and ASA, every child should follow up with pediatric cardiology to ensure that no cardiac issues arise due to this disease. This atypical presentation of Kawasaki Disease should remind clinicians to always be aware of the diverse manners in which this syndrome may appear.N
Renoprotective Effect of Egyptian Cape Gooseberry Fruit (Physalis peruviana L.) against Acute Renal Injury in Rats
No full textThis study aimed to evaluate the renoprotective effect of Physalis peruviana L. extract (PPE) on acute renal injury in rats. Adult male rats (n=36) were divided into six groups that were fed with basal diet throughout the experiment (33 days). The first group was normal group, the second and the third groups were administered orally with 100 and 150 mg PPE/kg body weight (BW) respectively, the fourth group was injected intraperitoneally with 5 mg/kg BW cisplatin once on the 28th day to induced ARI, and the fifth and sixth groups were treated like the second and the third groups and were injected with cisplatin on the 28th day. Many bioactive compounds were found in PPE. PPE did not cause any changes in the second and third groups compared to normal control group. Administration of PPE prior to cisplatin injection caused significant reduction in relative kidney weight, serum creatinine, urea, blood urea nitrogen, and significant increments in body weight, feed intake, total protein, albumin, and total globulin compared to cisplatin group. Pretreatment with PPE improved kidney histology and diminished the level of thiobarbituric acid reactive substances and enhanced other antioxidant enzymes in kidney homogenate compared to cisplatin group
ORIENTALISME ET ALTERITE DANS LE ROMAN ISTANBUL, SOUVENIRS D’UNE VILLE D’ORHAN PAMUK
No full textOrientalism is « the assimilation of Eastern elements into Western culture » according to the german author Harald Siebenmorgen. He asserts that there are two types of Orientalism. The first sees the East as agressive and hostile, while the second sees it as attractive and seductive through its exotic features. With this in mind, it seems appropriate to examine this notion in the light of the theory of otherness in Orhan Pamuk's novel Istanbul, Memories of a City. Obsessed with the idea of the double, the writer challenges the doxa relating to his culture, which oscillates between an aspect of alla turca on the one hand and alla franca on the other. He is convinced by the idea of dualism that inhabits his city and its objects, and assumes that it possesses « two souls : Eastern and Western ». This dualism was accentuated by the influence of French writers such as Nerval, Gauthier and Flaubert. In fact, he devotes separate chapters to these three orientalists. Our starting point will therefore be an overview of the concepts of Orientalism and otherness. We will then attempt to discern the aspects of the dialogue between East and West through Orhan Pamuk's Western upbringing
Photochemical Internalization of siRNA for Cancer Therapy
No full textSIMPLE SUMMARY: The objective of this review is to focus on the different nanovectors capable of transporting genetic material such as small-interfering RNA (siRNA) in order to block the expression of genes responsible for the development of cancer. Usually, these nanovectors are internalized by cancer cells via the endo-lysosomal pathway. To increase the lysosomal cargo escape, excitation using a lamp or a laser, can be applied to induce a more efficient leakage of siRNA to the cytoplasm, which is the site of action of the siRNA to block the translation of RNA into proteins. This is the mechanism of photochemical internalization. ABSTRACT: In the race to design ever more effective therapy with ever more focused and controlled actions, nanomedicine and phototherapy seem to be two allies of choice. Indeed, the use of nanovectors making it possible to transport and protect genetic material is becoming increasingly important. In addition, the use of a method allowing the release of genetic material in a controlled way in space and time is also a strategy increasingly studied thanks to the use of lasers. In parallel, the use of interfering RNA and, more particularly, of small-interfering RNA (siRNA) has demonstrated significant potential for gene therapy. In this review, we focused on the design of the different nanovectors capable of transporting siRNAs and releasing them so that they can turn off the expression of deregulated genes in cancers through controlled photoexcitation with high precision. This mechanism, called photochemical internalization (PCI), corresponds to the lysosomal leakage of the cargo (siRNA in this case) after destabilization of the lysosomal membrane under light excitation
The incidence of moderate and severe COVID-19 at Zagazig University Hospitals: A single center experience in Egypt
No full textBackground: Coronavirus Disease 2019 (COVID-19) is a paramount public health issue. The true statistics about COVID-19 in Egypt are veiled. Aim: To determine the incidence rate of moderate and severe SARS-CoV-2 infection among the patients seeking admission to Zagazig University Hospitals (ZUH), Egypt based on the chest Computed Tomography (CT) COVID-19 Reporting and Data System (CO-RADS) radiological criteria. Methods: All patients aged ≥ 18 years old seeking admission to ZUH between January 1st and March 31st, 2021, were eligible for enrollment in the study if they performed non-enhanced chest CT. Assessment of clinical, laboratory, and chest CT CO-RADS radiological criteria for each patient was carried out. The patients were defined to have moderate or severe COVID-19 if they met CO-RADS 4 or 5 radiological criteria, respectively, in association with the clinical and/or laboratory criteria. Results: A total of 5549 subjects were enrolled in the study. The total number of moderate and severe COVID-19 cases diagnosed at ZUH during January 2021 was 434/1827 with a monthly incidence rate of 23.75; 95% CI (21.9-25.8) per 100.000 of the population. The total number of moderate and severe COVID-19 cases during February 2021 was 215/1622 with a monthly incidence rate of 13.25; 95% CI (11.7-15). During March, the total number of moderate and severe COVID-19 cases was 416/2100 with a monthly incidence rate of 19.8; 95% CI (18.2-21.6). Conclusion: The incidence rate of moderate and severe COVID-19 infection at ZUH is in parallel with the national COVID-19 incidence reports
Super-resolution imaging of antibody-conjugated biodegradable periodic mesoporous organosilica nanoparticles for targeted chemotherapy of prostate cancer
No full textBiodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) are widely used as responsive drug delivery platforms for targeted chemotherapy of cancer. However, the evaluation of their properties such as surface functionality and biodegradability is still challenging, which has a significant impact on the efficiency of chemotherapy. In this study, we have applied direct stochastic optical reconstruction microscopy (dSTORM), a single-molecule super-resolution microscopy technique, to quantify the degradation of nanoPMOs triggered by glutathione and the multivalency of antibody-conjugated nanoPMOs. Subsequently, the effect of these properties on cancer cell targeting, drug loading and release capability, and anticancer activity is also studied. Due to the higher spatial resolution at the nanoscale, dSTORM imaging is able to reveal the structural properties (i.e., size and shape) of fluorescent and biodegradable nanoPMOs. The quantification of nanoPMOs' biodegradation using dSTORM imaging demonstrates their excellent structure-dependent degradation behavior at a higher glutathione concentration. The surface functionality of anti-M6PR antibody-conjugated nanoPMOs as quantified by dSTORM imaging plays a key role in prostate cancer cell labeling: oriented antibody is more effective than random ones, while high multivalency is also effective. The higher biodegradability and cancer cell-targeting properties of nanorods conjugated with oriented antibody (EAB4H) effectively deliver the anticancer drug doxorubicin to cancer cells, exhibiting potent anticancer effects.This research work is financially supported by the MANTARGET project of Marie Skłodowska-Curie Individual Fellowships (Project No.: 887089) under the Horizon 2020 Framework program. The authors would like to acknowledge Erwan Oliviero from the MEA platform, University of Montpellier, for acquiring energy-dispersive X-ray spectroscopy and elemental mapping of nanoPMOs. The authors also acknowledge Cristina Izquierdo Lozano, Eindhoven University of Technology, The Netherlands, and Teodora Andrian, Institute for Bioengineering of Catalonia (IBEC), Spain for helping in the MatLab analysis of dSTORM data, and also Madhura Murar, IBEC, Spain for her assistance in cell culture. P. D. also acknowledges the European Commission for Marie Skłodowska-Curie Individual Fellowships. S. P. acknowledges financial support from the Spanish Ministry of Science and Innovation (PID2019-109450RB-I00/AEI/10.13039/501100011033).Peer reviewe
Evaluating the Psychological Implications of the COVID-19 Pandemic Among Healthcare Workers: A Cross-Sectional Study
No full textConclusion: COVID-19 pandemic caused long-term psychological burden among HCWs. Further longitudinal researches are necessary to explore specific interventions to support HCWs’ mental health
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