1,721,208 research outputs found
Kiri Peterburi TA-le
Get PDFRochon, Alexis Marie de, 1741-1817, prantsuse astronoom ja optik, abt, Peterburi TA auliigeTeatab, et on kätte saanud Peterburi TA tööd. Kirjutab oma tööst optika alal
Thibaut Fleury Graff et Alexis Marie, Droit de l’asile, Paris, P. U. F., 2019
No full textEisemann Pierre Michel. Thibaut Fleury Graff et Alexis Marie, Droit de l’asile, Paris, P. U. F., 2019. In: Annuaire français de droit international, volume 64, 2018. p. 831
Alexis Marie, Le silence de l’État comme manifestation de sa volonté, Paris, Pedone, 2018
No full textLe Boeuf Romain. Alexis Marie, Le silence de l’État comme manifestation de sa volonté, Paris, Pedone, 2018. In: Annuaire français de droit international, volume 64, 2018. pp. 820-821
Hear Today, Gone Tomorrow: Exploring Quinoxaline Derivatives as a Treatment for Noise-Induced Hearing Loss
No full text2024According to the World Health Organization, there are 1.3 billion people around the world living with some degree of noise-induced hearing loss (NIHL) and 1 billion young adults at risk of developing NIHL. Currently, there are no FDA-approved drugs that protect the inner ear against NIHL. To address this need, my thesis aims to investigate the therapeutic potential of quinoxaline derivatives for NIHL. There is a large library of FDA-approved, commercially available quinoxaline-based drugs, and a study in zebrafish by Zallocchi, et al. (2021) found that quinoxaline derivatives were protective against excitotoxicity-induced hearing loss. The derivatives that conferred the most protection in zebrafish were selected for use in my thesis. The present study tested five derivatives – Qx3, Qx17, Qx23, Qx34, and Qx62 – in an in vivo mouse model for synaptopathy. Their therapeutic effects were quantified using auditory brainstem responses (ABR), distortion product otoacoustic emissions (DPOAE), and morphological analysis. The derivatives’ bioavailability was assessed using an in silico ADME assay from SwissADME. A kinome activity assay was performed on organs of Corti to assess changes in kinase activity following noise exposure. We found that Qx34 and Qx62 had the most beneficial effects on noise-exposed animals; they recovered ABR and DPOAE thresholds the fastest, preserved ABR wave I amplitude and latency, and prevented pre-synaptic ribbon loss. According to SwissADME, all five derivatives are highly orally bioavailable and will passively cross the blood-brain barrier, which means they will likely cross the blood-labyrinth barrier. The kinome assay predicted the upregulation of DDR1 and Tec kinases up to 21d post-noise exposure. This is a novel finding as these kinases have not been previously linked to NIHL pathogenesis. In all, Qx34 and Qx62 are the top derivatives from this study, and future studies are needed to assess their otoprotection following oral administration and at a higher noise level
Alexis-Marie Rochon (1741-1817), savant astronome et opticien
No full textSUMMARY. — In 1767, Alexis Rochon embarked for Morocco. In this way, he began a brillant career as an astronomer, a navigator, and an optician that he successfully maintained over several political and successive governments until his death in 1817. Invented in 1777, the prismatic micrometer used the rock-cristal birefringence. It gave the Rochon's name to posterity. This scientist did not cease improving his invention while Malus explained the birefringence phenomenon, paying homage to Rochon in the beginning of the XIXth century.RÉSUME. — En 1767, Alexis Rochon s'embarqua pour le Maroc. Il commençait ainsi une brillante carrière d'astronome, de navigateur et d'opticien qu'il poursuivit avec succès sous plusieurs régimes successifs, jusqu'à sa mort en 1817. Inventé en 1777, le micromètre prismatique utilisant la biréfringence du cristal de roche consacra son nom à la postérité. Rochon ne cessa pas de perfectionner son invention tandis que, tout en lui rendant hommage, Malus interprétait le phénomène de biréfringence au début du XIXe siècle.Fauque Danielle. Alexis-Marie Rochon (1741-1817), savant astronome et opticien. In: Revue d'histoire des sciences, tome 38, n°1, 1985. pp. 3-36
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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