130 research outputs found
Le son dans l'art contemporain canadien = Sound in Contemporary Canadian Art
No full textStemming from a research residency at Artexte Information Centre, Gingras has assembled this anthology of texts by 18 artists and authors, creating a forum for a discussion of sound in the visual and media arts in Canada from 1980 to the present. Focusing on a specific work or artist, or while discussing their own practice through writing or in interview, the authors reflect on different experiences of listening and hearing, on sound objects and acoustic bodies, broadcasting devices, interdisciplinarity, and the role of silence. Gingras’ essays encompass the artists who inspired this project, as well as issues involved in the creating, dissemination, reception and documentation of works of sound. The accompanying audio CD contains various sound recordings by 16 artists. Gingras’ texts in French and English; other texts in the language of the author. Biographical notes on the authors and on the artists represented on the CD. Circa 75 bibl. ref
The structure of an interdomain complex that regulates talin activity
No full textTalin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinhibited form of the molecule. Here, we report the solution structure of the primary F3 binding domain within the C-terminal region of the talin rod and use intermolecular nuclear Overhauser effects to determine the structure of the complex. The rod domain (residues 1655–1822) is an amphipathic five-helix bundle; Tyr-377 of F3 docks into a hydrophobic pocket at one end of the bundle, whereas a basic loop in F3 (residues 316–326) interacts with a cluster of acidic residues in the middle of helix 4. Mutation of Glu-1770 abolishes binding. The rod domain competes with β3-integrin tails for binding to F3, and the structure of the complex suggests that the rod is also likely to sterically inhibit binding of the FERM domain to the membrane.Benjamin T. Goult, Neil Bate, Nicholas J. Anthis, Kate L. Wegener, Alexandre R. Gingras, Bipin Patel, Igor L. Barsukov, Iain D. Campbell, Gordon C. K. Roberts and David R. Critchle
NMR structure of the S-domain of calreticulin, the sub-fragment that comprises the calreticulin binding site for defence collagens
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Open Access to Research: Changing Researcher Behavior Through University and Funder Mandates
No full textThe primary target of the worldwide Open Access initiative is the 2.5 million articles published every year in the planet's 25,000 peer-reviewed research journals across all scholarly and scientific fields. Without exception, every one of these articles is an author give-away, written, not for royalty income, but solely to be used, applied and built upon by other researchers. The optimal and inevitable solution for this give-away research is that it should be made freely accessible to all its would-be users online and not only to those whose institutions can afford subscription access to the journal in which it happens to be published. Yet this optimal and inevitable solution, already fully within the reach of the global research community for at least two decades now, has been taking a remarkably long time to be grasped. The problem is not particularly an instance of "eDemocracy" one way or the other; it is an instance of inaction because of widespread misconceptions (reminiscent of Zeno's Paradox). The solution is for the world's research institutions and funders to (1) extend their existing "publish or perish" mandates so as to (2) require their employees and fundees to maximize the usage and impact of the research they are employed and funded to conduct and publish by (3) depositing their final drafts in their Open Access (OA) Institutional Repositories immediately upon acceptance for publication in order to (4) make their findings freely accessible to all their potential users webwide. OA metrics can then be used to measure and reward research progress and impact; and multiple layers of links, tags, commentary and discussion can be built upon and integrated with the primary research
Talin at a glance
No full textCell migration, growth and differentiation all require the assembly and disassembly of cellular junctions with the extracellular matrix (ECM). These large multiprotein complexes assemble around the integrin family of cell adhesion molecules (transmembrane αβ heterodimers) that are typically linked to the actin cytoskeleton, with the exception of integrin α6β4, which is coupled to intermediate filaments. Talin is one of several proteins that link the cytoplasmic domains of integrin β subunits to actin filaments (others include α-actinin, filamin, tensin, integrin-linked kinase, melusin and skelemin) (Critchley, 2004
Maximizing Research Impact Through Institutional and National Open-Access Self-Archiving Mandates
No full textNo research institution can afford all the journals its researchers may need, so all articles are losing research impact (usage and citations). Articles made “Open Access,” (OA) by self-archiving them on the web are cited twice as much, but only 15% of articles are being spontaneously self-archived. The only institutions approaching 100% self-archiving are those that mandate it. Surveys show that 95% of authors will comply with a self-archiving mandate; the actual expe-rience of institutions with mandates has confirmed this. What institutions and funders need to mandate is that (1) immediately upon acceptance for publication, (2) the author’s final draft must be (3) deposited into the Institutional Repository. Only the depositing needs to be mandated; set-ting access privileges to the full-text as either OA or Restricted Access (RA) can be left up to the author. For articles published in the 93% of journals that have already endorsed self-archiving, access can be set as OA immediately; for the remaining 7%, authors can email the eprint in re-sponse to individual email requests automatically forwarded by the Repository
Minimum impact and immediacy of citations to physics open archives of arXiv.org: Science Citation Index based reports
No full textThe present work has calculated the minimum Open Archive Impact Factors and Open Archive Immediacy Index for the Physics Classes of arXiv.org as calculated for traditional journals in Journal Citation Reports of Institute of Scientific Information using Science Citation Index without the citation by the classes itself. The calculated Impact Factors reveal that High-Energy Physics classes of arXiv.org (‘hep-th’, ‘hep-lat’, ‘hep-ex’, and ‘hep-ph’) have made more impact on scientific community than any other classes except for the class ‘nucl-ex’. The Impact Factors for the year 2003 are: ‘hep-th’ (0.999), ‘nucl-ex’ (0.806), ‘hep-lat’ (0.766), ‘hep-ex’ (0.73), ‘hep-ph’ (0.719), ‘nucl-th’ (0.338), ‘quant-ph’ (0.334), ‘cond-mat’ (0.313), ‘astro-ph’ (0.195), ‘math-ph’ (0.162), ‘physics’ (0.061), and ‘gr-qc’ (0.002). It has been found that if the period for getting the citations to the open archive classes is considered one year as against two years for journal articles the rank of the classes are same. The immediacy of citing the Open Archives is also high for the High-Energy Physics classes. The Immediacy Indexes for the year 2003 are: ‘hep-ex’ (0.619), ‘hep-th’ (0.454), ‘hep-ph’ (0.44), ‘hep-lat’ (0.263), ‘nucl-ex’ (0.238), ‘quant-ph’ (0.202), ‘nucl-th’ (0.185), ‘cond-mat’ (0.168), ‘astro-ph’ (0.094), ‘math-ph’ (0.075), ‘physics’ (0.03), and ‘gr-qc’ (0.002). Definitely, the impact is much more than what is concluded from the calculated factors as the self-citations are not taken into the study. The above arguments may be strengthened if the study could use the web-tools like ‘Citebase’, ‘Citeseer’ etc
Effective Strategies for Increasing Citation Frequency
No full textDue to the effect of citation impact on The Higher Education (THE) world university ranking system, most of the researchers are looking for some helpful techniques to increase their citation record. This paper by reviewing the relevant articles extracts 33 different ways for increasing the citations possibilities. The results show that the article visibility has tended to receive more download and citations. This is probably the first study to collect over 30 different ways to improve the citation record. Further study is needed to explore and expand these techniques in specific fields of study in order to make the results more precisely
Altered matrix metalloproteinase expression associated with oncogene-mediated cellular transformation and metastasis formation
No full textMatrix metalloproteinase expression was examined in a series of mammalian cell lines of varying degrees of malignant progression, The expression of MMP-2 and MMP-9 was found to correlate with ras-mediated cellular transformation and as a function of malignant potential. Altered MMP-2 and MMP-9 expression was found to correlate also in other oncogene transformed cell lines and the level of expression of both MMP-2 and MMP-9 correlated with metastatic potential. Increased expression of both MMP-2 and MMP-9 was also found in cells which constitutively over-express MAP kinase kinase suggesting that one of the consequences of the persistent activation of the MAP kinase pathway is elevated expression of MMP-2 and MMP-9. Additionally, this study demonstrated a correlation between the expression of MMP-3 (stromelysin-l) and the level of ras expressed in cells and with the cells' ability to form tumors and with malignant potential. The existence of a novel 80 kDa caseinase activity which correlates with ras expression and the ability of the cell to form tumors was also demonstrated. The growth status of transformed cells was also found to be important in determining the expression of MMP-2 mRNA but not MMP-9 mRNA expression, and this expression was cell-type specific. This study also demonstrates that oncogenes can interact to influence and to determine the nature of the matrix metalloproteinases expressed and that this interaction results in a tumorigenic phenotype and, most importantly, contributes to the metastatic phenotype. Alterations in the expression and the regulation of MMPs, particularly MMP-2 and MMP-9, constitute an integral part of the altered growth regulatory program found within transformed cells and in particular, in transformed cells capable of malignant progression. (C) 2001 Academic Press.PT: J; CR: BALLIN M, 1988, BIOCHEM BIOPH RES CO, V154, P832 CHADDEE DN, 1995, J BIOL CHEM, V220, P28009 DENHARDT DT, 1987, ONCOGENE, V2, P55 DUFFY M, 1996, ADV CLIN CHEM, V132, P135 EGAN SE, 1987, MOL CELL BIOL, V7, P830 EGAN SE, 1987, SCIENCE, V238, P202 FUKAMI J, 1995, EXP CELL RES, V216, P107 GINGRAS MC, 1990, CANCER RES, V50, P4061 GOODMAN LV, 1989, J BIOL CHEM, V264, P5241 HURTA RAR, 1996, J CELL BIOCHEM, V60, P572 LOCHTER A, 1999, MOL BIOL CELL, V10, P271 MANSOUR SJ, 1994, SCIENCE, V265, P966 MATRISIAN LM, 1992, BIOESSAYS, V14, P455 OETKEN C, 1992, EXP CELL RES, V202, P370 RAY JM, 1994, EUR RESPIR J, V7, P2062 SAMUEL SK, 1992, EMBO J, V11, P1599 SCHWARZ LC, 1988, CANCER RES, V48, P6999 TAYLOR WR, 1992, ONCOGENE, V7, P1383 TUCK AB, 1991, J NATL CANCER I, V83, P485 WITTY JP, 1995, MOL BIOL CELL, V16, P1287 XHANG JY, 1992, CANCER RES, V52, P6682; NR: 21; TC: 10; J9: CELL BIOL INT; PG: 10; GA: 438KZSource type: Electronic(1
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