177 research outputs found
Pseudomelanoma follow-up of a recurrent naevus with dermoscopy and reflectance confocal microscopy
No full textPseudomelanom
Case Report: melanoma and melanocytic nevus differentiation with reflectance confocal microscopy. [v1; ref status: indexed, http://f1000r.es/5mr]
No full textHistorically, melanoma has been typically diagnosed by naked-eye examination and confirmed with invasive biopsy. However, recently the use of reflectance confocal microscopy enables non-invasive bedside diagnosis of clinically equivocal lesions. We present a case in which reflectance confocal microscopy was used to evaluate two skin lesions in the same patient confirming the diagnosis of a melanoma and potentially avoiding invasive biopsy in the second benign melanocytic lesion. Clinicians should be aware of the availability of new non-invasive technologies that can aid in early diagnosis of malignant skin tumors and potentially reduce the number of benign lesion excisions
Convolutional Neural Network Approach to Classify Skin Lesions Using Reflectance Confocal Microscopy
No full textWe propose an approach based on a convolutional neural network to classify skin lesions using the reflectance confocal microscopy (RCM) mosaics. Skin cancers are the most common type of cancers and a correct, early diagnosis significantly lowers both morbidity and mortality. RCM is an in-vivo non-invasive screening tool that produces virtual biopsies of skin lesions but its proficient and safe use requires hard to obtain expertise. Therefore, it may be useful to have an additional tool to aid diagnosis. The proposed network is based on the ResNet architecture. The dataset consists of 429 RCM mosaics and is divided into 3 classes: melanoma, basal cell carcinoma, and benign naevi with the ground-truth confirmed by a histopathological examination. The test set classification accuracy was 87%, higher than the accuracy achieved by medical, confocal users. The results show that the proposed classification system can be a useful tool to aid in early, noninvasive melanoma detection
Mergers and acquisitions in the European banking sector: An analysis of M&A activity, operating efficiency and shareholder returns
No full textPathophysiology of ageing, longevity and age related diseases
No full textAbstract On April 18, 2007 an international meeting on Pathophysiology of Ageing, Longevity and Age-Related Diseases was held in Palermo, Italy. Several interesting topics on Cancer, Immunosenescence, Age-related inflammatory diseases and longevity were discussed. In this report we summarize the most important issues. However, ageing must be considered an unavoidable end point of the life history of each individual, nevertheless the increasing knowledge on ageing mechanisms, allows envisaging many different strategies to cope with, and delay it. So, a better understanding of pathophysiology of ageing and age-related disease is essential for giving everybody a reasonable chance for living a long and enjoyable final part of the life.</p
Cost-benefit of reflectance confocal microscopy in the diagnostic performance of melanoma
No full textThe sub-optimal diagnostic accuracy for melanoma leads to excise a high number of benign lesions, with consequent costs. Reflectance confocal microscopy (RCM) improves diagnostic specificity, thus possibly inducing a reduction in unnecessary excisions and related costs
CD271 is expressed in melanomas with more aggressive behaviour, with correlation of characteristic morphology by in vivo reflectance confocal microscopy
No full textBackground Melanoma is the most highly aggressive type of skin cancer. Its resistance to existing treatments and the rapid rise in incidence underscore the importance of acquiring a better understanding of melanomagenesis. Objectives To assess the impact of reflectance confocal microscopy (RCM) on the description of cell morphology, which may influence the growth pattern and changes with increasing tumour severity, correlating with biological aspects. Methods A retrospective analysis of 30 primary melanomas in vivo, evaluated by RCM, to correlate cell morphology and cellular arrangement with a marker of melanoma progression (CD271) using immunohistochemical evaluations. Results Typical cells organized in dermal nests with peculiar in vivo confocal morphology result in melanoma with high malignancy and positivity to CD271. This architecture might be due to the presence of a type of cells, intrinsically predisposed to invasion, as a result of dedifferentiation programming, revealed by expression of the neural crest marker CD271. Conclusions With the hypothesis that dedifferentiated cells would be strongly responsible for initiation of tumour development and progression, we propose that CD271 detection could be associated with RCM evaluation in order to detect more aggressive melanoma subtypes
The Role of Internal M&A Teams in Takeovers
No full textThis article provides insights into the inner workings of internal corporate M&A teams using survey evidence from sixty-five firms from Austria, Germany, and Switzerland. We find that internal teams create value, especially relative to external advisors, by directing transaction rationales, screening targets, and employing performance metrics to assess post-merger success. Teams emphasizing economic rationales as a merger motive are associated with higher returns than those teams more apt to consider behavioral motives. We consider several team characteristics and find that financial experience is the most persistent and significant attribute in explaining the outcomes across various deal stages. Another key result from our survey-based evidence is that latent M&A team factors explain ∼54% of the acquirer fixed effects in announcement return regressions
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