1,591 research outputs found
, Ross Laird
No full textRoss Laird, PhD RCC is a clinical consultant focused on trauma, addictions, and social vulnerability. He is also a best-selling author, award-winning scholar and educator, and clinical supervisor for BC’s largest licensed non-profit program in addictions, trauma, and mental health. Dr. Laird focuses particularly on traumatized and marginalized client populations — those navigating homelessness, mental illness, and complex trauma — and provides professional development training for organizations that serve them: social service agencies, first responders, cultural groups, nonprofits, and educational institutions. He also works extensively with organizations in arts and culture and Indigenous communities to develop trauma-informed practices for cultural programming, museum exhibitions, and community initiatives
Lettre d'Alexander Morris à David Laird sur la fin du procès de A.-D. Lepine
No full text4 pages, copie manuscrite (letterpress)Lettre d'A[lexander] Morris à D[avid] Laird sur : la fin du procès de [A.-D.] Lepine; le refus de sir Edmund Head d'agir selon l'avis du Conseil [Exécutif]; la réduction de la présence militaire; la préparation de la prochaine session du Parlement provincial; la présence possible de [Louis] Riel; le salaire d'un juge; un mémoire du Père [Albert] Lacombe, qui a vécu parmi les Pieds-Noirs et les Cris
Tumbled smooth by the rapids: Rediscovering and reconnecting in the wake of turbulence
No full textRoss Laird, PhD RCC is a clinical consultant focused on trauma, addictions, and social vulnerability. He is also a best-selling author, award-winning scholar and educator, and clinical supervisor for BC’s largest licensed non-profit program in addictions, trauma, and mental health. Dr. Laird focuses particularly on traumatized and marginalized client populations — those navigating homelessness, mental illness, and complex trauma — and provides professional development training for organizations that serve them: social service agencies, first responders, cultural groups, nonprofits, and educational institutions. He also works extensively with organizations in arts and culture and Indigenous communities to develop trauma-informed practices for cultural programming, museum exhibitions, and community initiatives.presentationBetter Together Conferenc
Laird Alexander F. McKenzie of McKenzie Lake on horseback
No full textHandwritten inscription on back reads: "Laird McKenzie of McKenzie Lake, One Mile Creek, 1904.
Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
Freud e Johnson-Laird: Modelos Mentais no «Caso Dora»
No full textAfreudite : Revista Lusófona de Psicanálise Pura e AplicadaTrabalho sobre a relação entre a teoria dos modelos mentais de Johnson-Laird e o conceito de transferência em Freud.The author underline the relationship between Johnson-Laird's mental patterns theory and the concept of transfer in Freud
Trends in nontariff barriers of developed countries : 1966-1986
No full textWhile major concerns have been expressed about the spread of non-tariff barriers (NTBs) in developing countries, the lack of empirical information on the dimensions of the increase has affected the related policy debates. Using inventories of NTBs in developed countries compiled for 1966 and 1986, this study develops quantitative information on the major expansions of NTBs that occurred over this 20 year period. The paper finds that in 1966 NTBs affected 25 percent of developed countries imports, while in 1986 this share has increased to 48 percent. A second major point documented in the study is that the spread of NTBs has been uneven across countries and industrial sectors. Third, this study shows that the increased resort to discriminatory NTBs like"voluntary"export restraints (particularly in the U.S.) caused a significantly higher share of trade to be"affected"by NTBs than suggested by commonly used trade coverage ratios. The findings concerning the extent that NTBs have proliferated in some sectors (and countries) also increases the importance of establishing effective procedures for liberalization of these measures in multilateral trade negotiations like the Uruguay Round.Environmental Economics&Policies,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Economic Theory&Research,Trade Policy,Transport and Trade Logistics
Export prospects of Middle Eastern countries : a post-Uruguay Round analysis
No full textExports in the Middle Eastern countries should increase from 900 million as a result of the tariff cuts agreed on in the Uruguay Round, according to the author.This represents an annual expansion of less than 1 percent. Projected gains are small because the erosion of tariff preferences that Middle Eastern countries received in OECD markets offset the positive effects of reduced most-favored-nation tariffs on nonpreference-receiving products. And petroleum, the main Middle Eastern export--which generally faces zero or low tariffs--is unaffected by the Uruguay Round reductions. Egypt's projected gains (about $20 million, or under 0.5 percent of total exports) are concentrated largely in agricultural exports to the European Union and manufactures in the United States. Israel should experience net trade losses because of the erosion of its free trade preferences in the European Union and the United States. The Uruguay Round made major progress in removing nontariff barriers that Middle Eastern exports face, especially in agriculture, textiles, and clothing. But with the removal of the Multifibre Arrangement, international trade in textiles and clothing will become much more competitive. Middle Eastern countries must adopt measures to cut costs and increase efficiency to remain viable exporters. As a result of what was achieved in the Uruguay Round, the average OECD nontariff barrier coverage ration for Middle Eastern exports should fall from a current 10 percent to between 1 and 2 percent. Net food importing countries could be adversely affected by the higher international food prices expected to result from the Uruguay Round agreement. There is a clear priority for net food importers to adopt reforms stimulating domestic production. Prospects for increased trade in the Middle East are constrained by the similar comparative advantages and export profiles of many Middle Eastern countries. The most favorable prospects for intraregional trade appear to be between countries such as Cyprus, Israel, Lebanon, and Turkey--net energy importers--and the rest of the region.Trade Policy,Economic Theory&Research,Agribusiness&Markets,Environmental Economics&Policies,Export Competitiveness,TF054105-DONOR FUNDED OPERATION ADMINISTRATION FEE INCOME AND EXPENSE ACCOUNT,Economic Theory&Research,Trade Policy,Agribusiness&Markets,Export Competitiveness
The True Nature of the Satyricon?
No full textThis paper considers the Satyrica in relation to the developing history of Greek prose fiction, highlighting some problems presented by a panoramic view of Greco-Roman literary history for interpretation of this work. The aim of this discussion is not to argue firmly for a later period of composition for the Satyrica, but to highlight the fact that its date has not yet been properly settled. This awkward question cannot but bear on the way in which the work is viewed in relation to a constellation of potential Greek influences and sources. Andrew Laird is Reader in Classical Literature in Warwick University. He has published widely on Latin prose fiction and is co-editor of A Companion to the Prologue of Apuleius\u27 Metamorphoses (OUP 2001). He is author of Powers of Expression, Expressions of Power (OUP 1999) and The Epic of America (Duckworth 2006)
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