2,821 research outputs found
Alexander Hicks Letters, MSS.3368
No full textAbstract: The Alexander Hicks Letters contain three letters written probably during or shortly after the conclusion of the American Civil War. Hicks writes that he is in reasonably good health, his company of soldiers has an abundance of clothes and food, and hopes to return home soon. One letter, written from Hicks' sister, begs to know if he is dead or alive.Scope and Content Note: The Alexander Hicks Letters contain three letters written probably during or shortly after the conclusion of the American Civil War. Two letters are written from Alexander Hicks to his "Dear Mother," Mrs. Dicy Hicks, and are dated April 24, 1866, and June 30, 1866. The April 24th letter was written from Washington, D. C. and the June 30th letter was written from Fort Carroll, Maryland. Hicks writes that he is in reasonably good health, his company of soldiers has an abundance of clothes and food, and hopes to return home soon.In the April 24th letter, he instructs his mother that she should take Charly's children to an agent of the Freedman's Bureau, state the case to him, and get his advice.The third, undated, letter is written from Elizabeth Hicks, of Louisville, Kentucky, Alexander's sister, and begs to know whether he is dead or alive. The letter informs Alexander that their mother died on the last 8th of April and exhorts him to send the family news of his condition.Biographical/Historical Note
Dr. Doug Hicks – Faculty Author Interview
No full textThe Podcasts@Boatwright debut author is Dr. Doug Hicks, associate professor of leadership studies and religion and executive director of the Bonner Center for Civic Engagement. His new book, With God on All Sides: Leadership in a Devout and Diverse America, describes how our various religious traditions can help build common ground in America and how leaders can and should deal with religious diversity
A method of predicting changes in human gene splicing induced by genetic variants in context of cis-acting elements
No full textBackground: polymorphic variants and mutations disrupting canonical splicing isoforms are among the
leading causes of human hereditary disorders. While there is a substantial evidence of aberrant splicing
causing Mendelian diseases, the implication of such events in multi-genic disorders is yet to be well
understood. We have developed a new tool (SpliceScan II) for predicting the effects of genetic
variants on splicing and cis-regulatory elements. The novel Bayesian non-canonical 5’GC splice site (SS)
sensor used in our tool allows inference on non-canonical exons. Result: our tool performed favorably when compared with the existing methods in the context of genes
linked to the Autism Spectrum Disorder (ASD). SpliceScan II was able to predict more aberrant
splicing isoforms triggered by the mutations, as documented in DBASS5 and DBASS3 aberrant splicing
databases, than other existing methods. Detrimental effects behind some of the polymorphic variations
previously associated with Alzheimer’s and breast cancer could be explained by changes in predicted
splicing patterns. Conclusions: we have developed SpliceScan II, an effective and sensitive tool for predicting the
detrimental effects of genomic variants on splicing leading to Mendelian and complex hereditary
disorders. The method could potentially be used to screen resequenced patient DNA to identify de novo
mutations and polymorphic variants that could contribute to a genetic disorde
Writers Talk featuring authors Troy Hicks and Elaine Wolf
No full textElaine Wolf, author of Camp, talks to OSU students Erin Reilly-Sanders and Allison Fetzer. Author and teacher Troy Hicks talks to OSU employee Kevin Cordi about the impact of technology on the teaching of writing.The media can be accessed here: http://streaming.osu.edu/knowledgebank/WritersTalk-Audio/WT_2013-3-18-Hicks_Wolf.mp3Ohio State University. Center for the Study and Teaching of Writin
Oral history interview with Charles R Hicks, 2008 Jan. 14
No full textHicks talks about early years and coming to Purdue in 1953 as faculty member in the Department of Mathematics and Statistics. He became head of the Department of Education 1960 and in 1971 he reorganized it into nine sections. Hicks talks about the challenges and responsibilities as a department head including faculty research, faculty recruitment, and appointment of key people as assistant heads. Hicks was accredited by NCATE [National Council For Accreditation of Teacher Education]. He discusses the state of teacher preparation in the 1970s, 1980s and into the 21st century. Hicks discusses a trip in 1968 behind the Iron Curtin on the contrast in culture and life under Communism. Hicks is a researcher and author in the field of design of experiments
Willet Hicks letter to Charity Rotch, New York, 3 mo 7th, 1806
No full textNews of family to Charity Rotch in Hartford from Willet Hicks in New York. Quakers often quoted the Bible in their letters which were similar to Epistles as this author mentions in this letter on page three.7.75" x 12.75" (19.9 by 33 cm
A Third Dimension : An Exhibition of Sculpture by Tommie Gallie, Gary Williams, Robert Hicks
No full textThe author briefly points out how Gallie, WIlliams and Hicks expand the concept of sculpture. Includes artists' statements and biographical notes
Computational prediction of splicing regulatory elements shared by Tetrapoda organisms
No full textBackground: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites. These cis-acting motifs have been termed splicing enhancers and silencers and are located both in introns and exons. They co-evolved into an intricate splicing code together with additional functional constraints, such as tissue-specific and alternative splicing patterns. We used orthologous exons extracted from the University of California Santa Cruz multiple genome alignments of human and 22 Tetrapoda organisms to predict candidate enhancers and silencers that have reproducible and statistically significant bias towards annotated exonic boundaries.Results: a total of 2,546 Tetrapoda enhancers and silencers were clustered into 15 putative core motifs based on their Markov properties. Most of these elements have been identified previously, but 118 putative silencers and 260 enhancers (~15%) were novel. Examination of previously published experimental data for the presence of predicted elements showed that their mutations in 21/23 (91.3%) cases altered the splicing pattern as expected. Predicted intronic motifs flanking 3' and 5' splice sites had higher evolutionary conservation than other sequences within intronic flanks and the intronic enhancers were markedly differed between 3' and 5' intronic flanks.Conclusion: difference in intronic enhancers supporting 5' and 3' splice sites suggests an independent splicing commitment for neighboring exons. Increased evolutionary conservation for ISEs/ISSs within intronic flanks and effect of modulation of predicted elements on splicing suggest functional significance of found elements in splicing regulation. Most of the elements identified were shown to have direct implications in human splicing and therefore could be useful for building computational splicing models in biomedical researc
Inequalities, Agency, and Well-being: Conceptual Linkages and Measurement Challenges in Development
No full textdevelopment, inequality, gender, well-being, agency, capability, distribution, Sen
Robert Hicks Marker Emporia, VA
No full textRobert Hicks Marker UM-49 Emporia, VA
Robert Hicks was born about 1658. By the 1690 he lived at Fort Henry near Petersburg and led traders to the Indians on the southern frontier. About 1709 he moved here to the future site of Hicksford (present-day Emporia) and became captain of the Surry County Rangers, a frontier militia unit. He commanded Fort Christanna from about 1714 to 1718. In 1722 he helped Virginia Lt. Gov. Alexander Spotswood conclude a peace treaty with the Iroquois in Albany, New York. He briefly joined William Byrd II and his crew surveying the Virginia-North Carolina boundary line in 1729. Hicks died nearby before 7 Feb 1739/40.
Department of Historic Resources, 1997.https://digitalcommons.unf.edu/historical_architecture_main/8207/thumbnail.jp
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