51 research outputs found
Rhynie chert Prototaxites taiti dataset
No full text3D models of Prototaxites taiti from the 407 million year old Rhynie chert. Photogrammetry was used to capture the external 3D structure of two Rhynie chert blocks. Block North Sea Core (NSC) 36 and Lyon collection block 156. After describing the external surface of NSC36 we cut the specimen to investigate internal structure and produced another photogrammetry model of the cut specimen. Alongside our investigations with photogrammetry we produced a 3D model of complex tube branching within a medullary spot. This investigation was based on using confocal laser scanning microscopy to investigate thin section NMS G.2024.5.7 (MPEG0057). The dataset is related to the upcoming publication by Corentin C. Loron, Laura M. Cooper, Sean McMahon, Seán F. Jordan, Andrei V. Gromov, Matthew Humpage, Laetitia Pichevin, Hendrik Vondracek, Ruaridh Alexander, Edwin Rodriguez Dzul, Alexander T. Brasier, Alexander J. Hetherington. (In submission).>README.txt
A readme file providing information about the five image files.
>Images_of_sampled_fossils.zip
Images of fossils sampled by ATR-FTIR
>MPEG0057_2024_03_25__12_47_29_airyscan_Substack (1-114)_zstack.tif
Airyscan confocal z-stack produced from thin section National Museum Scotland (NMS) G.2024.5.7 (MPEG0057).
>MPEG0057 spot model.obj
3D model of medullary spot, produced from Airyscan confocal z-stack of thin section National Museum Scotland (NMS) G.2024.5.7 (MPEG0057)
>NSC36 whole block_scaled.oj
3D photogrammetry model of complete Rhynie chert Block North Sea Core (NSC) 36.
>NSC 36 cut_scaled.obj
3D photogrammetry model of Rhynie chert Block North Sea Core (NSC) 36, after the specimen had been cut.
>block 156 scaled.obj
3D photogrammetry model of Rhynie chert Lyon collection block 156
Preface
No full textThe University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Graduate Linguistics Society. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from NWAV and the Penn Linguistics Colloquium/Conference. This volume contains selected papers from the New Ways of Analyzing Variation 48 (NWAV 48), held October 10-12, 2019 in Eugene, Oregon at the University of Oregon.
Thanks go to Faruk Akkus, George Balabanian, Johanna Benz, Nikita Bezrukov, Pik Yu May Chan, Gwen Hildebrandt, Alexandros Kalomoiros, Daoxin Li, Lefteris Paparounas, Nari Rhee, Caitlin Richter, Ollie Sayeed, and Christine Soh for their help in editing.
Since Vol. 14.2, PWPL has been an internet-only publication. As of September 2014, the entire back catalog has been digitized and made available on ScholarlyCommons@Penn. Please continue citing PWPL papers or issues as you would a print journal article, though you may also provide the URL of the manuscript.
An example is below:
Ceolin, Andrea. 2020. On functional load and its relation to the actuation problem. In University of Pennsylvania Working Papers in Linguistics 26.2, ed. Ruaridh Purse and Yosiane White, 39–48. Available at: http://repository.upenn.edu/pwpl/vol26/iss2/5
Publication in the University of Pennsylvania Working Papers in Linguistics (PWPL) does not preclude submission of papers elsewhere; copyright is retained by the author(s) of individual papers.
The PWPL editors can be contacted at: U. Penn Working Papers in Linguistics, Department of Linguistics, 3401-C Walnut Street, Suite 300, C Wing, Philadelphia, PA 19104-6228 and [email protected].
Ruaridh Purse and Yosiane White, Issue Editor
Preface
No full textThe University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Graduate Linguistics Society. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from NWAV and the Penn Linguistics Colloquium/Conference. This volume contains selected papers from New Ways of Analyzing Variation 47 (NWAV 47), held October 18-21, 2018 in New York City, NY, at NYU.
Thanks go to Johanna Benz, Spencer Caplan, Gwen Hildebrandt, Jordan Kodner, Aini Li, Daoxin Li, Hassan Munshi, Lefteris Paparounas, Nari Rhee, Caitlin Richter, Jia Tian and Hong Zhang for their help in editing.
Since Vol. 14.2, PWPL has been an internet-only publication. As of September 2014, the entire back catalog has been digitized and made available on ScholarlyCommons@Penn. Please continue citing PWPL papers or issues as you would a print journal article, though you may also provide the URL of the manuscript.
An example is below:
Hall, Erin and Ruth Maddeaux. 2020. /u/-fronting and /æ/-raising in Toronto Families. In University of Pennsylvania Working Papers in Linguistics 25.2, ed. Ruaridh Purse and Yosiane White, 51-60. Available at: http://repository.upenn.edu/pwpl/vol25/iss2/7
Publication in the University of Pennsylvania Working Papers in Linguistics (PWPL) does not preclude submission of papers elsewhere; copyright is retained by the author(s) of individual papers.
The PWPL editors can be contacted at: U. Penn Working Papers in Linguistics, Department of Linguistics, 3401-C Walnut Street, Suite 300, C Wing, Philadelphia, PA 19104-6228 and [email protected].
Ruaridh Purse and Yosiane White, Issue Editor
Preface
No full textThe University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Graduate Linguistics Society. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from NWAV and the Penn Linguistics Colloquium/Conference. This volume contains selected papers from New Ways of Analyzing Variation 47 (NWAV 47), held October 18-21, 2018 in New York City, NY, at NYU.
Thanks go to Johanna Benz, Spencer Caplan, Gwen Hildebrandt, Jordan Kodner, Aini Li, Daoxin Li, Hassan Munshi, Lefteris Paparounas, Nari Rhee, Caitlin Richter, Jia Tian and Hong Zhang for their help in editing.
Since Vol. 14.2, PWPL has been an internet-only publication. As of September 2014, the entire back catalog has been digitized and made available on ScholarlyCommons@Penn. Please continue citing PWPL papers or issues as you would a print journal article, though you may also provide the URL of the manuscript.
An example is below:
Hall, Erin and Ruth Maddeaux. 2020. /u/-fronting and /æ/-raising in Toronto Families. In University of Pennsylvania Working Papers in Linguistics 25.2, ed. Ruaridh Purse and Yosiane White, 51-60. Available at: http://repository.upenn.edu/pwpl/vol25/iss2/7
Publication in the University of Pennsylvania Working Papers in Linguistics (PWPL) does not preclude submission of papers elsewhere; copyright is retained by the author(s) of individual papers.
The PWPL editors can be contacted at: U. Penn Working Papers in Linguistics, Department of Linguistics, 3401-C Walnut Street, Suite 300, C Wing, Philadelphia, PA 19104-6228 and [email protected].
Ruaridh Purse and Yosiane White, Issue Editor
Preface
No full textThe University of Pennsylvania Working Papers in Linguistics (PWPL) is an occasional series published by the Penn Graduate Linguistics Society. The series has included volumes of previously unpublished work, or work in progress, by linguists with an ongoing affiliation with the Department, as well as volumes of papers from NWAV and the Penn Linguistics Colloquium/Conference. This volume contains selected papers from the New Ways of Analyzing Variation 48 (NWAV 48), held October 10-12, 2019 in Eugene, Oregon at the University of Oregon.
Thanks go to Faruk Akkus, George Balabanian, Johanna Benz, Nikita Bezrukov, Pik Yu May Chan, Gwen Hildebrandt, Alexandros Kalomoiros, Daoxin Li, Lefteris Paparounas, Nari Rhee, Caitlin Richter, Ollie Sayeed, and Christine Soh for their help in editing.
Since Vol. 14.2, PWPL has been an internet-only publication. As of September 2014, the entire back catalog has been digitized and made available on ScholarlyCommons@Penn. Please continue citing PWPL papers or issues as you would a print journal article, though you may also provide the URL of the manuscript.
An example is below:
Ceolin, Andrea. 2020. On functional load and its relation to the actuation problem. In University of Pennsylvania Working Papers in Linguistics 26.2, ed. Ruaridh Purse and Yosiane White, 39–48. Available at: http://repository.upenn.edu/pwpl/vol26/iss2/5
Publication in the University of Pennsylvania Working Papers in Linguistics (PWPL) does not preclude submission of papers elsewhere; copyright is retained by the author(s) of individual papers.
The PWPL editors can be contacted at: U. Penn Working Papers in Linguistics, Department of Linguistics, 3401-C Walnut Street, Suite 300, C Wing, Philadelphia, PA 19104-6228 and [email protected].
Ruaridh Purse and Yosiane White, Issue Editor
A framework for comparing nuclear warhead authentication protocols
No full textThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, 2019Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (pages 173-179).Even with the end of the Cold War, nuclear arms control continues to be a cornerstone of strategic stability and international non-proliferation efforts. New treaties are necessary to build upon, or at least maintain, the status-quo, and will rely upon verification technologies and protocols to ensure all sides are dismantling their warheads as promised. The nuclear weapon states refuse to participate in any process which might reveal the design of their warheads to an adversary or would-be proliferator. This makes warhead authentication, the critical verification step where the object to be dismantled is confirmed to be an authentic warhead, especially challenging. Despite several decades of research, there is no agreed means of describing or assessing warhead authentication protocols. This has hindered protocol development, and made it more difficult for the policy and technical communities to communicate what is important and feasible.This thesis presents a framework for describing warhead authentication protocols and quantifying their performance. The framework draws on methods used to assess digital authentication protocols, as well as information theoretic analysis of privacy. A model is developed for describing authentication protocols; showing how authentication questions, physical properties, and measurable data relate to one another. This allows the objectives and assumptions of a protocol to be made explicit, helping to ensure that protocols are compared fairly. It was found that the protocols in the literature have made use of very different assumptions, and that has influenced their choices of measurement technology and concepts of operation. Having established how to describe protocols, the thesis investigates how best to quantify the completeness (type I error rate), soundness (type II error rate), and information privacy of a protocol.While the absolute soundness cannot be calculated without knowledge of all possible hoaxes, a conditional soundness can be estimated using a minimax approach. A new measure of information privacy is presented, based on a change in the KL divergence between an inspector's beliefs and the actual warhead design, when the inspector starts from an incorrect prior.by Ruaridh Reid Macdonald.Ph. D.Ph.D. Massachusetts Institute of Technology, Department of Nuclear Science and Engineerin
Rhynie chert Prototaxites taiti dataset
No full text3D models of Prototaxites taiti from the 407 million year old Rhynie chert. Photogrammetry was used to capture the external 3D structure of two Rhynie chert blocks. Block North Sea Core (NSC) 36 and Lyon collection block 156. After describing the external surface of NSC36 we cut the specimen to investigate internal structure and produced another photogrammetry model of the cut specimen. Alongside our investigations with photogrammetry we produced a 3D model of complex tube branching within a medullary spot. This investigation was based on using confocal laser scanning microscopy to investigate thin section NMS G.2024.5.7 (MPEG0057). The dataset is related to the upcoming publication by Corentin C. Loron, Laura M. Cooper, Sean McMahon, Seán F. Jordan, Andrei V. Gromov, Matthew Humpage, Laetitia Pichevin, Hendrik Vondracek, Ruaridh Alexander, Edwin Rodriguez Dzul, Alexander T. Brasier, Alexander J. Hetherington. (In submission)
Regional Geology and Fracture Network Characterisation of the Southern Chotts and Jeffara Basins, Central Tunisia: Implications for Petroleum Reservoirs
No full textThe Southern Chotts and Jeffara Basins are situated within the Saharan Domain of Central Tunisia, North Africa. The Southern Chotts Basin hosts reservoirs within the Triassic, Permian and Ordovician units that contain significant hydrocarbon accumulations whilst the Jeffara Basin contains outcrop analogues of the same hydrocarbonbearing formations. The basins experienced a late Hercynian shortening phase which involved the uplift of a major topographic high (Tebaga de Medenine). This high, in conjunction with a older regional high, the Telemzane Arch influenced the deposition and geometry of the Permian and Triassic units across both basins. This shortening event is characterised at the scale of hundreds of meters by EW striking folds into which the midlate Triassic and early Jurassic units are deposited. The folding is also observed at field scale (10’s meters) through small faultrelated folds in the Permian deposits of the Tebaga de Medenine. This late Hercynian phase occurs between the late Permian and early Jurassic in the basins. Fracture data collected from the upper Permian and lower Triassic units (Jeffara Basin) provides an analogue to the fracture networks at depth (Southern Chotts Basin) in the Paleozoic reservoirs. A conjugate fracture system observed in the field (from fracture pavements) corroborates with the interpretation of regional shortening in the basins. Seismic attribute analysis on depth slices in the Paleozoic reservoirs also shows the conjugate system at depth. This analysis is integrated with outcrop fracture data and FMI data from wells to create an open fold distributed fracture model of the system in the basins. This model indicates the main driver for fracture generation in the region is folding and is used to predict the fracture networks at depth. This is undertaken using discrete fracture network (DFN) modelling of the subsurface. This model is integrated with a deterministic model from the seismic time slices to create a hybrid predictive fracture model of the early Paleozoic reservoirs. Analytical aperture modelling of the fracture model demonstrates the fractures varied in openness depending on orientation and fracture length. The conjugate set orientated at 240∘and longer joints detected from seismic attributes presented the widest aperture size. These fractures in the subsurface at implications on the transmissibility of the reservoirs, especially Permian units which have low bulk rock permeability and the lower Triassic (TAGI) sequences which are susceptible to compartmentalisation
Small satellite operations planning for agile disaster response using graph theoretical techniques
Get PDFAgile, manoeuvrable, satellite constellations have the potential to fundamentally change space mission design by moving away from traditional missions, designed to address predicted demand, and instead providing responsive systems that can react to real-time events, such as natural disasters. The unique advantages of responsive constellations are enhanced by the use of small satellites, whose short development times and low cost can offset the increased risk and shorter mission life inherent in the use of manoeuvrable spacecraft. In addition, newly developed, highly efficient propulsion systems can provide small satellites with agile manoeuvrability. This could enable agile satellite systems where efficient, low-thrust, responsive manoeuvres can be used to ensure rapid flyover of targets on Earth. The authors have previously developed a fully analytical method of designing such manoeuvres, which allows consideration of multiple targeting options, each with different flyover times, view angles, and propellant requirements. However, a long-term, holistic understanding of the concept of operations is required to effectively implement an agile satellite system. To facilitate this, the existing analytical methodology has been combined with graph theoretical techniques to allow the complex trade-space to be perceived as a graph. The connections in the graph represent possible manoeuvres and are rapidly traversed to identify favourable routes to achieve the desired goal. The effect of changes in mission priorities can be assessed by reweighting the graph, avoiding the need to recalculate the manoeuvre options. This work demonstrates that the proposed method can be successfully used to plan sequential flyovers of a moving target; in this case, a tropical storm. For the small spacecraft and low-thrust propulsion system considered, the possible changes in flyover time for each target are small, however, these small adjustments can be used to significantly improve the quality of the obtained data compared to a non-manoeuvring spacecraft
C1orf106 (INAVA) is a SMAD3-dependent TGF-β target gene that promotes clonogenicity and correlates with poor prognosis in breast cancer
Get PDFfirst_pagesettingsOrder Article Reprints
Open AccessArticle
C1orf106 (INAVA) Is a SMAD3-Dependent TGF-β Target Gene That Promotes Clonogenicity and Correlates with Poor Prognosis in Breast Cancer
by Lauren S. Strathearn 1,2,†,Lindsay C. Spender 1,3ORCID,Christina Schoenherr 2ORCID,Susan Mason 2,Ruaridh Edwards 1ORCID,Karen Blyth 2ORCID andGareth J. Inman 1,2,4,*ORCID
1
Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee DD1 4HN, UK
2
Cancer Research UK Scotland Institute, Garscube Estate, Bearsden, Glasgow G61 1BD, UK
3
Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee DD1 4HN, UK
4
Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1BD, UK
*
Author to whom correspondence should be addressed.
†
Current address: Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Cells 2024, 13(18), 1530; https://doi.org/10.3390/cells13181530
Submission received: 23 February 2024 / Revised: 2 September 2024 / Accepted: 5 September 2024 / Published: 12 September 2024
(This article belongs to the Section Cell Signaling)
Downloadkeyboard_arrow_down Browse Figures Review Reports Versions Notes
Abstract
Transforming Growth Factor-β (TGF-β) can have both tumour-promoting and tumour-suppressing activity in breast cancer. Elucidating the key downstream mediators of pro-tumorigenic TGF-β signalling in this context could potentially give rise to new therapeutic opportunities and/or identify biomarkers for anti-TGF-β directed therapy. Here, we identify C1orf106 (also known as innate immunity activator INAVA) as a novel TGF-β target gene which is induced in a SMAD3-dependent but SMAD2/SMAD4-independent manner in human and murine cell lines. C1orf106 expression positively correlates with tumourigenic or metastatic potential in human and murine breast cancer cell line models, respectively, and is required for enhanced migration and invasion in response to TGF-β stimulation. C1orf106 promoted self-renewal and colony formation in vitro and may promote tumour-initiating frequency in vivo. High C1orf106 mRNA expression correlates with markers of aggressiveness and poor prognosis in human breast cancer. Taken together, our findings indicate that C1orf106 may act as a tumour promoter in breast cancer
- …
