243 research outputs found
Sudden unexpected death in alcohol misuse – an unrecognized public health issue?
No full textSudden arrhythmic cardiac death can occur in chronic misusers of alcohol. The only findings at post mortem are fatty liver and a negative or low blood alcohol. This is an under-recognized entity. Coroner‘s post mortems in a typical UK city were studied. Seven out of 1,292 (0.5%) post mortems were deemed to have died of alcohol associated arrhythmic death. Applying this study to the UK as a whole, alcohol related arrhythmic death or as we have termed it SUDAM (Sudden Unexpected Death in Alcohol Misuse) probably accounts for around 1,000 deaths, many of which are misattributed to other cause
Hipposideros ater Templeton 1848
No full textHipposideros ater Templeton, 1848 Dusky leaf-nosed bat New records Lampung Province: Kuyung Arang Village, Sumber Rejo Village. New material One individual was collected as a voucher specimen. Lampung Province: Way Canguk Forest, 1♀ (MZB 34983). Previous records from Sumatra Lampung Province: Way Canguk Forest (Khan, 2013). Remarks This small species can be distinguished from most Hipposideros by smaller body size (Table 2) and from H. doriae by presence of vertical septa in the posterior noseleaf. In comparison with species of the bicolor -group known for the Sunda Shelf, the body size and noseleaf shape were closest to those of H. ater, H. cineraceus, and H. dyacorum (Corbet and Hill, 1992; Yasuma et al., 2003; Francis, 2008). The internarial septum is pinkish or grayish purple, and the top half of the ear is rounded, contrasting with the darkish septum and triangular ears of H. dyacorum. The internarial septum is swollen at the base and gradually narrows towards the top, a condition similar to H. ater from Pahang state of Malaysia and different from H. cineraceus from Pahang, in which the internarial septum is swollen at the middle (Kingston et al., 2006) and H. dyacorum from Malaysia which is very narrow (Murray et al., 2012). Khan’s (2013) molecular analysis included one sample from Way Canguk Forest and found it to be genetically identical to the Java population of H. ater (as H. a. saevus -1 by the author). In our study area, it is smaller than H. bicolor (see species account below) but bigger than H. doriae, and can be distinguished from H. cervinus by absence of lateral leaflets on the muzzle and smaller body size.Published as part of Huang, Joe Chun-Chia, Jazdzyk, Elly Lestari, Nusalawo, Meyner, Maryanto, Ibnu, Maharadatunkamsi, Wiantoro, Sigit & Kingston, Tigga, 2014, A recent bat survey reveals Bukit Barisan Selatan Landscape as a chiropteran diversity hotspot in Sumatra, pp. 413-449 in Acta Chiropterologica 16 (2) on page 426, DOI: 10.3161/150811014X687369, http://zenodo.org/record/394361
Trail log - 2019
No full textSummary: March: "bomb cyclone," heavy snow. April: Pasqueflowers on Good Friday; June: Templeton Annual Meeting in Nassau. July: International Society for Environmental Ethics (ISEE) Annual Meeting in H. J. Andrews Experimental Forest, Oregon. Spotted owls vs. barred owls. August 31-September 1. Redfeather Lakes to visit daughter Shonny on her newly acquired property there. Trip to Creedmore Lakes. November 25-26. 15.5 inches of snow - second most snow on record in Fort Collins in November
Teaching managers: Learning, research and workplace practice
No full textThis is the author's PDF version of an article published in Journal of Management Development ©2010. The definitive version is available at www.emeraldinsight.com.This article explores the way in which professional management programmes are informed by research and workplace practice. The focus is on the areas of motivation, appraisal and the management of change. A longitudinal study using a mixed methods approach was used. Middle and senior managers engaged on professional management programmes were surveyed on workplace practice. Literature reviewed included syllabus guidelines from professional bodies and selected core textbooks. A content analysis revealed that there was a lack of congruence between what is taught to managers and workplace practice. However, research was found to have an impact on teaching and indirectly it influenced individual beliefs if not organisational practice. Conclusions indicate that professional management programmes are still failing to bridge the gap between syllabus content current research and workplace practice. There is little to show that the needs of Business are being satisfied compared to successful models embedded in other professions
Practice-oriented controversies and borrowed epistemic credibility in current evolutionary biology: phylogeography as a case study
No full textAlthough there is increasing recognition that theory and practice in science are intimately intertwined, philosophy of science perspectives on scientific controversies have been historically focused on theory rather than practice. As a step in the construction of frameworks for understanding controversies linked to scientific practices, here we introduce the notion of borrowed epistemic credibility (BEC), to describe the situation in which scientists, in order to garner support for their own stances, exploit similarities between tenets in their own field and accepted statements or positions properly developed within other areas of expertise. We illustrate the scope of application of our proposal with the analysis of a heavily methods-grounded, recent controversy in phylogeography, a biological subdiscipline concerned with the study of the historical causes of biogeographical variation through population genetics- and phylogenetics-based computer analyses of diversity in DNA sequences, both within species and between closely related taxa. Toward this end, we briefly summarize the arguments proposed by selected authors representing each side of the controversy: the ‘nested clade analysis’ school versus the ‘statistical phylogeography’ orientation. We claim that whereas both phylogeographic ‘research styles’ borrow epistemic credibility from sources such as formal logic, the familiarity of results from other scientific areas, the authority of prominent scientists, or the presumed superiority of quantitative vs. verbal reasoning, ‘theory’ plays essentially no role as a foundation of the controversy. Besides underscoring the importance of strictly methodological and other non-theoretical aspects of controversies in current evolutionary biology, our analysis suggests a perspective with potential usefulness for the re-examination of more general philosophy of biology issues, such as the nature of historical inference, rationality, justification, and objectivity
Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway
No full textProstaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma
An EdD in a PhD World: Developing a Scholarly Identity in a World That May Not Always Recognize You as Legitimate
No full textThis chapter discusses the author's experience as a Doctorate of Education (EdD) student and graduate, a degree that is often perceived to be less rigorous and research-intensive as a PhD. After explaining why she decided to pursue this degree, the author describes how she developed her scholarly identity as “an EdD in a PhD world.” Among other things, the author details moments of imposter syndrome and moments of empowerment, especially from other EdD graduates, that helped shape her experience. She concludes the chapter with recommendations for other EdD students and for hiring committees in higher education.This is an Accepted Manuscript of a book chapter published by Routledge/Taylor & Francis as Doran, E.E. (2021). An Ed.D. in a Ph.D. world: Developing scholarly identity in a world that may not always recognize you as legitimate. In E. Templeton, B.H. Love, & O. Johnson (eds.), Elevating marginalized voices in academe: Lessons for a new generation of scholars (pp. 110-114). Routledge.
It is available online at DOI: 10.4324/9781003044338.
Copyright 2021 Emerald Templeton, Bridget H. Love, & Onda Johnson.
Posted with permission
Immunolocalization of c-myc epitope-tagged PFE1605w PHIST protein within infected erythrocytes.
No full textA) Synchronized parasites were harvested at different time points after Percoll-sorbitol purification, air-dried and fixed with ice-cold methanol. Epitope-tagged proteins were stained with anti-c-myc monoclonal antibodies that were conjugated with FITC. Nuclei were stained with DAPI (blue). The abbreviations used to describe parasite stages are as follows: 22 h, late ring stage; 30 h, early-trophozoite stage; 42 h, mid-trophozoite stage; 48 h, late trophozoite stage; and schizont stage. B) Co-localization was assayed using rabbit polyclonal SBP1 followed by goat anti-rabbit IgG conjugated with Alexa 594 (red). C) The pattern of expression of c-myc epitope-tagged PFE1605w PHIST protein is dependent on the fixation protocol. When infected erythrocytes are fixed in solution with 1% paraformaldehyde, 0.075% glutaraldehyde, then PHIST protein shows a broader punctate expression than the Maurer’s cleft marker, SPB1.</p
The Free Energy Requirements of Biological Organisms; Implications for Evolution
No full textRecent advances in nonequilibrium statistical physics have provided unprecedented insight into the thermodynamics of dynamic processes. The author recently used these advances to extend Landauer’s semi-formal reasoning concerning the thermodynamics of bit erasure, to derive the minimal free energy required to implement an arbitrary computation. Here, I extend this analysis, deriving the minimal free energy required by an organism to run a given (stochastic) map π from its sensor inputs to its actuator outputs. I use this result to calculate the input-output map π of an organism that optimally trades off the free energy needed to run π with the phenotypic fitness that results from implementing π. I end with a general discussion of the limits imposed on the rate of the terrestrial biosphere’s information processing by the flux of sunlight on the Earth.Foundational Questions Institute (FQXi) (Grant No. FQXi-RHl3-1349)Templeton World Charity Foundation (Grant No. TWCF0079/AB47
Increased cell wall chitin and β-glucan in <i>A. fumigatus</i> isolate Af5517.
No full text<p>(<b>A,B</b>) Representative dot-blot images of processed <i>A. fumigatus</i> mycelial extracts and chitin (shrimp shell chitin) (<b>A</b>) or β-glucan (curdlan) (<b>B</b>) standards, probed with chitin binding probe or anti-(1,3)-β-glucan, respectively. Blots of mycelial extracts depict 75 µg (A) and 100 µg (B) of total protein of each isolates. (<b>C,D</b>) Chitin (<b>C</b>) or β-glucan (<b>D</b>) vs. total fungal protein in mycelial extracts as determined by dot blot assay. (<b>C</b>) Chitin was significantly increased compared to other isolates at 25, 50, or 75 µg of total protein, while β-glucan (<b>D</b>) was significant at 50 and 100 µg total protein. ****p<0.0001. (<b>A–D</b>) Panels are representative of two experiments. (<b>E,F</b>) Representative flow cytometric histograms of dormant (0 h) or swollen (5 h at 37°C) conidia of each isolate stained with the chitin binding wheat germ agglutinin (WGA, panel E) or anti-(1,3)-β-glucan (<b>F</b>). Negative controls are unstained conidia (<b>E</b>) or goat anti-mouse alexa-fluor 488 only (<b>F</b>) and depicted as dotted histograms. (<b>G,H</b>) Median fluorescence intensities of WGA (<b>G</b>) or anti-β-glucan (<b>H</b>) stained conidia after 0 or 5 hours incubation at 37°C. (<b>G</b>) Chitin exposure in Af5517 conidia was significantly increased in comparison will all other isolates after 0 and 5 hours incubation. *p<0.05. **p<0.01. Panels are a summary of three experiments.</p
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