391 research outputs found
Il fondo Mosconi di Sandrà
No full textPresentazione del fondo Mosconi-Negri di Sandrà di Castelnuovo del Garda (Vr), di recente aperto agli studiosi e contenente una ricca sezione pistolare (più di 6.000 pezzi compresi tra il 1722 e il 1869) e di manoscritti autografi di vari autori del Sette-Ottocento (Giacomo Leopardi, Cesare Betteloni, Giacomo Mosconi, Ippolito Pindemonte, Vincenzo Monti, Jean-Baptiste de Montgrand, Clara Maffei, Aleardo Aleardi, Melchiorre Missirini, Opprandino Arrivabene, Caterina Bon Brenzoni, Luigi Carrer, Angelo Messedaglia, Pompeo Molmenti, Bennassù Montanari, Alberto Nota, Giovanni Scopoli, Antonio Fortunato Stella, Alessandro Torri e altri
Divine. Nuove prospettive sul cinema muto italiano
No full textIl volume affronta il divismo cinematografico italiano del periodo del muto attraverso casi di studio che mettono in luce nuove prospettive di indagine e nuovi ritrovamenti archivistici in particolare sulle dive italiane
Diegetic versus nondiegetic: a reconsideration of the conceptual opposition as a contribution to the theory of audiovision
No full textThe essay offers a history of the concept "diegesis" and of the conceptual opposition "diegetic/nondiegetic" from its introduction in French film studies during the 1950s to their most recent uses. The reconsideration of the opposition is necessary in order to escape the unconscious realism implicit in the concept as well as to develop a theory of audiovision based on a consciously constructivist approach to the audiovisual products
Diegetico vs. extradiegetico: revisione critica di un'opposizione concettuale in vista di una teoria dell'audiovisione
No full textIl saggio ricostruisce la storia del concetto di diegesi e dell'opposizione concettuale diegetico/extradiegetico nell'ambito degli studi di cinema, dalla loro introduzione ad opera degli studiosi francesi negli anni cinquanta, agli usi più recenti. Dopo una sua definizione basata su citazioni dirette e sulla loro discussione puntuale, il saggio procede a una critica filosofica del concetto, intesa come presupposto necessario per lo sviluppo di una teoria dell'audiovisione che sia in grado superare tanto il realismo ingenuo implicito nella definizione del concetto quanto le aporie a cui facilmente conduce, in direzione di una concezione consapevolmente costruttivista del prodotto audiovisivo
Gene expression profiles of putative biomarkers in juvenile loggerhead sea turtles (Caretta caretta) exposed to polycyclic aromatic hydrocarbons
No full textThere is evidence that polycyclic aromatic hydrocarbons (PAHs) are consistently the predominant organic contaminants in concentration found in loggerhead sea turtles (Caretta caretta) from the North and Central Adriatic Sea. Hence this study investigates the PAH toxicity to loggerheads by using a particular set of genes [i.e. CYP1B, CAT, GPX, GSTT1, SOD3, DNMT1, Epoxide hydrolase 1 (EPHX1), Poly (ADP-ribose) polymerase 1 (PARP1), Lamin-A/C isoform 3 (LMNA), Talin 1 (TLN1), Annexin A1 (ANXA1)] whose altered expression is potentially dependent on and specific for the PAH-related mechanism of action. Twenty healthy juvenile loggerheads were thus divided into high and low exposure groups (mean of ΣPAHs: 80.34 ng mL-1 vs. 8.84 ng mL-1, P < 0.0001) according to the median split of ΣPAHs. Interestingly, we found that the whole blood mRNA levels of each gene biomarker tested were significantly increased in high PAH-exposed turtles thus proving to be useful for the biological monitoring of PAH toxicity and hematotoxicity in sea turtles
Organic UV Filters Induce Toll-like-Receptors and Related Signaling Pathways in Peripheral Blood Mononuclear Cells of Juvenile Loggerhead Sea Turtles (Caretta caretta)
No full textRecent evidence suggests that exposure to organic ultraviolet filters (UV filters) is associated with dysregulated neuroendocrine-immune homeostasis. Marine species are likely to be among the most vulnerable to UV filters due to widespread diffusion of these chemicals in the aquatic environment. In the present study, the effects of UV filter bioaccumulation on toll-like-receptors (TLRs) and related signaling pathways were investigated in peripheral blood mononuclear cells (PBMCs) of juvenile loggerhead sea turtles (Caretta caretta). We found that the expression of both TLR1 and TLR2 was significantly increased in UV-filter exposed turtles compared to control animals. Similarly, the signaling pathway downstream of activated TLRs (i.e., Ras-related C3 botulinum toxin substrate 1 (RAC1), Phosphoinositide 3-kinase (PI3K), serine/threonine-protein kinase (AKT3), and nuclear factor κB (NF-κB)) was significantly up-regulated, leading to an enhanced transcription of pro-inflammatory cytokines. In addition, we demonstrated that high levels of plasma UV filters increased lipid peroxidation in sea turtles’ PBMCs. Our results indicated that UV filters affected the inflammatory responses of PBMCs via modulation of the TLR/NF-κB signaling pathway and provided a new insight into the link between exposure to sunscreen agents and sea turtle health
Pregnane X receptor (PXR) signaling in seabream primary hepatocytes exposed to extracts of seawater samples collected from polycyclic aromatic hydrocarbons (PAHs)-contaminated coastal areas
No full textPolycyclic aromatic hydrocarbons (PAHs) are persistent organic pollutants damaging to the marine environment and the wildlife. Herein, we investigated the effects of extracts from coastal seawaters (central Adriatic sea, Italy), showing high concentrations of PAHs, on pregnane X receptor (PXR)-transcriptional regulation of the cytochrome P450 3A (CYP3A) gene using seabream primary hepatocytes. The results show that concentrated extracts of seawater with original ΣPAH concentrations above the putative threshold of 30 ng L-1 increased expression of PXR and its main target gene, CYP3A. Similar results were observed for LXR and its target gene SREBP-1c suggesting pathway cross-talk. These data are further supported by the finding of multiple PXR and LXR response elements in the putative promoters of their target genes. Overall, our data indicate the capacity of seawater extracts, containing environmentally relevant levels of PAHs, to affect multiple pathways, including lipid and cholesterol metabolism
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