844 research outputs found
Egresada UCC. Alessandra Mazzoni
No full textAlessandra se formó en Tecnología de los Alimentos con nosotros y actualmente es consultora de cervecerías artesanales y realiza control de calidad de alimentos. Conversamos con ella de su experiencia en la Católica
Family interactions: Protective and risk factors associated with severe developmental problems.
No full textObservation of family interactions is essential to study child development trajectories. Several procedures evaluated
the development of family coordination and coparenting from the pre-natal period through to preschool years
(Fivaz-Depeursinge, Corboz-Warnery, 1999; Favez et al., 2006; McHale, 2011) and several studies observed the
quality of family interactions considered as risk and protective factors related to child functioning (Feldman, 2007;
Jacobvitz et al., 2004; Mazzoni et al., 2010). Such studies may improve psychoeducational and psychotherapeutic
interventions (Sameroff, 2004). The Symposium aim is to focus on parenting at risk because of child
psychopathology and to discuss both assessment procedures and proposal of interventions.
Feldman will present results from two longitudinal studies, the first following a group of well-functioning parents
and their firstborn from birth to 3 years, the second assessing children exposed to chronic maternal depression from
birth to five years. In the first study, maternal and paternal Oxytocin and micro-level triadic interactions in the first
7 six months of life predict children's interactions with their best friends at 3 years, indicating a transfer from the
atmosphere of the family to the first close non-kin relationship. The second study addresses the father role in the
context of chronic maternal depression and shows that father engagement and coparental mutuality within a triadic
family interaction at five years predicts lower child propensity for psychopathology, higher child social engagement,
and more optimal HPA-axis functioning among children of depressed mothers. Lucarelli, Simonelli and Ammaniti
will focus on Infantile Anorexia. Considering previous results that showed mother-child conflictual interactions
during feeding and pointed out that maternal depression and eating disorders are frequently associated with IA, the
present research will explore the influence of the paternal role on mother-child affective differentiation process in
children with IA. The LTP paradigm was adapted to observe father-mother-infant primary triangle in the feeding
context, compared to the play context; results highlight that the procedure is useful in providing an overview of
family interactions and in showing limitations and resources of the family relational functioning. Mazzoni, Veronesi
& Vismara will present the clinical LTP proposed to families with children who have an Autistic Spectrum Disorder
(ASD). Families showed different types of miscoordination at the level of participation, role organization, focal
attention and affective contact. Despite the fact that family functionality was correlated with children functionality
(ADOS), some cases demonstrate a counterintuitive trend: e.g. child high functionality/low family functionality and
vice versa
Study of association between oncogenic polyomaviruses and ocular melanoma, and p53 gene analysis of the tumor in relation to the radio-therapy resistance.
No full textThe aim of this study is to verify the putative association between oncogenic polyomaviruses (1), and ocular melanoma (OM). To this purpose two cohorts composed of ocular melanoma affected patients and healthy blood donors, employed as a control group, are enrolled in this investigation. The two cohorts have the same median age. The association of polyomaviruses with OM is investigated by searching, in serum samples, specific antibodies against viral capsid proteins. Serum antibodies against polyomaviruses are analyzed by an indirect ELISA with synthetic peptides which mimic specific capsid polypeptide antigens (2). In the first step of our investigation indirect ELISAs employing synthetic peptides was set up and standardized for the detection of specific serum antibodies against polyomaviruses SV40, BKV and JCV. ELISA data showing the prevalence of anti-polyomavirus antibodies in serum samples from OM patients, compared to that detected in samples from healthy subjects will be presented.
It has been shown that p53 gene mutations affect more than 50% of human tumors. p53 gene mutations, in exons 5-8, are responsible of absence of apoptosis, and resistance to chemo- and radio-therapies. The aims of our study is to verify whether ocular melanomas, which are resistant to radio-therapy (20%), carry specific p53 mutations in comparison to the p53 profile of radio-therapy sensitive tumors.
1. Martini F, Corallini A, Balatti V, Sabbioni S, Pancaldi C, Tognon M. Simian virus 40 in humans. Infect. Agent and Cancer. 2007;2:1-13.
2. Corallini A, Mazzoni E, Taronna A, Manfrini M, Carandina G, Guerra G, Guaschino R, Vaniglia F, Magnani C, Casali F, Dolcetti R, Palmonari C, Rezza G, Martini F, Barbanti-Brodano G, Tognon MG. Specific antibodies reacting with simian virus 40 capsid protein mimotopes in serum samples from healthy blood donors. Hum. Immunol. 2012;73:502-510
THE COLLABORATIVE INTERACTION SCALE REVISED FOR COUPLE THERAPIES: FROM THE FOCUS ON THE RUPTURES TO THE POSSIBILITY TO STUDY THE REPARATIONS STRATEGIES
No full textThe research in the field of individual psychotherapy and, to a lesser extent, in the field of Family and Couple Therapy (CFT), identifies the Therapeutic Alliance (TA) as one of the most important factors in the patient-therapist relationship when it comes to the outcome (Escudero, 2015; Bartle - Haring, et al., 2012; Smerud & Rosenfarb, 2011; Friedlander, et al., 2011; Muñiz de la Peña, et al., 2009; Knobloch – Fedders, et al., 2007). CFT ‘s studies still give little space to the comprehension of how this factor and the therapeutic process are co-constructed in a session through special interactive dynamics of ruptures and reparations (Friedlaner, et al., 2006; Muntigl & Horvath, 2016; Swank & Wittenborn, 2013; Escudero, et al., 2012). The aim of this study is to explore the ruptures and reparations that occur in the first and last session (N:68) of three different Couple Therapy (CT), differentiated from the status termination (Agreement, Disagreement and No Show. N: 34). The instrument is the Collaborative Interaction Scale-revised (Colli & Lingiardi, 2014) combined with a custom-built scale, in order to detect the specific interactive dynamics of the systemic levels (Therapist-Couple; Partner-Partner). The results show a significant difference from the first to the last session, for both ruptures and reparations in the patient-therapist relationship and between partners. Lastly, we will discuss the clinical relapses in order to improve the treatment, with the aim to increase the patient's engagement, the success of the treatment, and the partners' wellness
Prefazione all'edizione italiana di "La sfida della cogenitorialità"
No full textNel libro l'autore spiega in che modo i genitori lavorano-o non lavorano- insieme quando si occupano di figli e come la qualità della loro alleanza, cioè la capacità di sostenersi reciprocamente e di confrontarsi sulle decisioni che riguarano i figli, si rifletta sullo sviluppo sociale ed emotivo del bambino nei primi tre anni di vita. Arricchito da molte interviste con neo genitori, il volume offre informazioni fondamentali su come creare strategie genitoriali coerenti e coordinate durante la gravidanza e nel periodo iniziale di crescita del bambino
High-Resolution X-Ray Tomography: A 3D Exploration Into the Skeletal Architecture in Mouse Models Submitted to Microgravity Constraints
No full textBone remodeling process consists in a slow building phase and in faster resorption with the objective to maintain a functional skeleton locomotion to counteract the Earth gravity. Thus, during spaceflights, the skeleton does not act against gravity, with a rapid decrease of bone mass and density, favoring bone fracture. Several studies approached the problem by imaging the bone architecture and density of cosmonauts returned by the different spaceflights. However, the weaknesses of the previously reported studies was two-fold: on the one hand the research suffered the small statistical sample size of almost all human spaceflight studies, on the other the results were not fully reliable, mainly due to the fact that the observed bone structures were small compared with the spatial resolution of the available imaging devices. The recent advances in high-resolution X-ray tomography have stimulated the study of weight-bearing skeletal sites by novel approaches, mainly based on the use of the mouse and its various strains as an animal model, and sometimes taking advantage of the synchrotron radiation support to approach studies of 3D bone architecture and mineralization degree mapping at different hierarchical levels. Here we report the first, to our knowledge, systematic review of the recent advances in studying the skeletal bone architecture by high-resolution X-ray tomography after submission of mice models to microgravity constrains
Recombinant expression of Pleurotus ostreatus laccases in Kluyveromyces lactis and Saccharomyces cerevisiae
No full textHeterologous expression of Pleurotus ostreatus POXC and POXA1b laccases in two yeasts, Kluyveromyces lactis and Saccharomyces cerevisiae, was performed. Both transformed hosts secreted recombinant active laccases, although K. lactis was much more effective than S. cerevisiae. rPOXA1b transformants always had higher secreted activity than rPOXC transformants did. The lower tendency of K. lactis with respect to S. cerevisiae to hyperglycosylate recombinant proteins was confirmed. Recombinant laccases from K. lactis were purified and characterised. Specific activities of native and recombinant POXA1b are similar. On the other hand, rPOXC specific activity is much lower than that of the native protein, perhaps due to incomplete or incorrect folding. Both recombinant laccase signal peptides were correctly cleaved, with rPOXA1b protein having two C-terminal amino acids removed. The availability of the established recombinant expression system provides better understanding of laccase structure-function relationships and allows the development of new oxidative catalysts through molecular evolution techniques
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