4,540 research outputs found
RESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS
No full textRESVERATROL-INDUCED AUTOPHAGY CONTRIBUTES TO THE INHIBITION OF EPSTEIN BARR VIRUS REPLICATION IN BURKITT’S LYMPHOMA CELLS
De Leo Alessandra (a), Colavita Francesca (a), Arena Giuseppe (b), Mattia Elena (a)
(a) Dip. di Scienze di Sanità Pubblica e Malattie Infettive “Sanarelli”, Univ. di Roma “Sapienza”
(b) Casa Sollievo della Sofferenza Hospital, CSS-Mendel Institute, Roma
Presenting author: De Leo Alessandra, [email protected]
We have previously examined the antiviral activity of resveratrol on the replication of Epstein Barr Virus (EBV), the etiologic agent of infectious mononucleosis and associated with several types of malignancies of epithelial and lymphoid origin.
In a cellular context that allows in vitro EBV activation and lytic cycle progression through mechanisms closely resembling those that in vivo initiate and enable productive infection, we found that RV inhibited EBV lytic genes expression and the production of viral particles in a dose-dependent manner
Il disegno della città nelle tavole del De Nola. Analisi geometrico-dimensionale delle iconografie
No full textThis paper introduces the analysis of the ancient city of Nola through the comparative study of two Tables among the four attached to De Nola Treatise (1514) by Ambrogio Leone, also in comparison with the contemporary city. These drawings are an important graphic-documentary testimony of the finds of the ancient city in the Renaissance period as well as the theoretical-geometric knowledge of the author discussed in this essay. Starting from the graphic analysis of Table II entitled Nola Vetus, this research studies its geometric-dimensional aspects, based on the Science of Drawing, not only for a critical reinterpretation of Tables attached to Treatise but also to connect the ancient city to the traces still today present in the contemporary territory.
This essay consolidates the multifaceted character of the author as a draftsman, topographer and typographer as well as a humanist scholar, together with the essays by Argenziano and Pisacane in this Proceedings book and in continuity with the research already presented at the UID 2020 Conference
L’occhio immobile di Quad che ferma il mondo / Quad’s Motionless Gaze that Stopsthe World
No full textUn’opera di straordinario ermetismo che racconta, come ci dice Deleuze di un gruppo di quattro
‘esausti’ personaggi e del loro moto ordinato attraverso cui ‘esauriscono’ tutto lo spazio a loro disposizione,
percorrendone la distanza nell’unico modo a loro concesso, evitando con cura di ‘toccarsi’.
Liberata totalmente dalla parola, l’opera si presenta come ‘ritornello essenzialmente motorio’, gesto
del corpo che disegna il proprio percorso nello spazio del quadrato e in questo gesto visivamente
lo genera, gli conferisce un senso e al tempo stesso lo esaurisce. A partire dalla lettura del ‘testo’
di Beckett e dalla sua declinazione visiva in alcune sperimentazioni attuate in contesti accademici, il
saggio si lascia sedurre dalla potente metafora che sembra legare l’opera di Beckett alla attuale condizione
esistenziale e ne propone una lettura in cui i concetti di linguaggio (e per esso linguaggio del
corpo e traiettoria nello spazio/tempo), distanza (e per esso misura ad quadratum la cui potenzialità
è nel centro) e tecnologia (nel senso pieno di technè e dunque di dispositivo spazio/temporale che
dialoga oggi con la dimensione digitale) articolano una narrazione di imponderabile potenza in cui la
messa in scena dell’opera di Beckett, nel suo tempo e nel tempo a venire, si declina oggi nella metafora
della condizione esistenziale che il ‘distanziamento’ fisico ed emotivo ci costringe a sperimentare.extraordinary
hermeticism, it tells, as Deleuze says, of a group of four ‘exhausted’ characters and their
orderly movement through which they ‘exhaust’ all the space available to them, covering the distance
in the only way allowed to them, carefully avoiding ‘touching’ each other. Totally free of words, the
work appears as an ‘essentially motor refrain’, a gesture of the body that traces its own path through
the space of the square and in this gesture visually generates it, gives it meaning and at the same time
exhausts it. Starting from a reading of Beckett’s ‘text’ and its visual declination in some experiments
carried out in academic contexts, the essay lets itself be seduced by the powerful metaphor that
seems to link Beckett’s work to the current existential condition and proposes an interpretation in
which the concepts of language (and for it body language and trajectory in space/time), distance (and
for this reason misura ad quadratum whose potentiality is in the centre) and technology (in the full
sense of technè and therefore of a space/time device that dialogues today with the digital dimension)
articulate a narrative of imponderable power in which the staging of Beckett’s work, in its time and
in the time to come, is declined today in the metaphor of the existential condition that the physical
and emotional ‘distancing’ forces us to experience
Tecniche di rilevamento e disegno edile/cad. Un’esperienza didattica di Rilievo Digitale Integrato.
No full textThe integrated digital survey of the building assigned to the Course to perform the case study, provides an opportunity for learners to acquire the critical knowledge and operational control of the current methodologies of the architectural and urban survey. The reference, as regards measurement, is to the techniques of the survey manual and compare to the most innovative sensing technologies; the reference, as regards restitution, is to analogical process and to digital CAD process and to post-processing of the data acquired with laser technology
Catturare il paesaggio mediterraneo attraverso tecniche di navigazione e rilevamento cinematico tridimensionale
No full textLa Riforma Agraria tra continuita e innovazione
No full textLa Storia del paesaggio agrario italiano di Sereni si chiude con l’esito delle lotte contadine per la terra: è la storia di uno dei momenti di più aspro confronto politico nella transizione
tra il fascismo e la democrazia nel secondo dopoguerra; è il tentativo di costruire una politica territoriale unitaria, che dovrebbe investire l’intero territorio nazionale; è un
capitolo rimosso della storia dell’urbanistica e della pianificazione in Italia, forse perché vista come un atto compiuto “senza urbanisti” ma rilevante in quanto, accanto a forme di
continuità con il passato, introduce innovazioni nelle pratiche progettuali che possono essere ritrovate in esperienze coeve o, addirittura, successive.Emilio Sereni’s History of the Rural Landscape ends with the result of the peasants’ fights for the land: it was one of the hardest moments of political contrast, during the transition
between the Fascism and the democracy; it was maybe the first effort to construct a regional policy, that should involve the whole national territory; it was a forgotten part in the history
of Italian planning, maybe because it had been realised without planners, but it introduced innovations in design practices, that can be recognised in other following experiences
Somatostatin receptor subtype-dependent regulation of NO release: involvement of different intracellular pathways
No full textWe reported previously that, in addition to direct effects, somatostatin (SST) affects tumor growth inhibiting the tumoral neoangiogenesis, via an interference with NO synthesis. Here, we analyzed the effects of SST on nitric oxide (NO) production induced by different agonists [basic fibroblast growth factor (bFGF), insulin, cholecystokinin (CCK)] and the intracellular signaling involved, using Chinese hamster ovary-k1 cells stably transfected with individual SSTR1-SSTR4. bFGF and insulin induced endothelial nitric oxide synthase activity via the generation of ceramide or the Akt-dependent phosphorylation of endothelial nitric oxide synthase, respectively. CCK regulates neuronal nitric oxide synthase activity in a Ca++-dependent manner. SST inhibited NO production stimulated by bFGF through SST receptor 1 (SSTR1), SSTR2, and SSTR3 and by CCK through SSTR2 and SSTR3. In all the cell lines, SST treatment did not modify NO synthesis induced by insulin. SSTR4 activation was not effective on any of the stimuli tested. The effects on bFGF-induced NO production were downstream from receptor phosphorylation and ceramide synthesis. SSTR2 and -3 on CCK activity were related to the inhibition of intracellular Ca++ mobilization, whereas the lack of effects on insulin was paralleled by the absence of SST activity on Akt phosphorylation. These data, identifying for the first time a selective receptor subtype-inhibitory role of SST on NO generation, may open new perspectives in the use of SST agonists to control tumoral angiogenesis
Correction to: Malignant epithelioid neoplasm of the ileum with ACTB-GLI1 fusion mimicking an adnexal mass (BMC Women's Health, (2022), 22, 1, (104), 10.1186/s12905-022-01679-0)
No full textFollowing publication of the original article (1), The author names were incorrectly published as Ambrosio Marco, Virgilio Agnese, Raffone Antonio, Arena Alessandro, Raimondo Diego, Alletto Andrea, Seracchioli Renato and Casadio Paolo. But this should have been Marco Ambrosio, Agnese Virgilio, Antonio Raffone, Alessandro Arena, Diego Raimondo, Andrea Alletto, Renato Seracchioli, and Paolo Casadio. The original article has been updated
Pneumococcal disease in a paediatric population in a hospital of central Italy: a clinical and microbiological case series from 1992 to 2006
No full textOBJECTIVES: Streptococcus pneumoniae is frequently isolated from carrier children, but it also causes localized and invasive diseases. Increasing incidence of chemoresistance can affect the efficacy of empiric therapy and it motivates interest in primary prophylaxis. The study aims to investigate clinical and microbiological features of paediatric pneumococcal infections in an Italian province.
METHODS: Retrospective clinical analysis of 640 children, hospitalized from 1992 to 2006 with one culture positive for S. pneumoniae, was performed. Chemosusceptibility tests and serotyping were carried out on isolates; statistical analysis was applied to compare variables.
RESULTS: Overall, 47.8% were carriers, 49% and 3.2% had, respectively, a localized or invasive disease; S. pneumoniae aetiology accounted for 25% of meningitis and 16% of sepsis. On the total isolates, 10.2% were penicillin non-susceptible, 35.15% were erythromycin resistant, with increasing rates over years. Prevalent invasive serotypes were 1 (38.1%) and 7F (9.5%).
CONCLUSIONS: The study sustains pneumococcal disease relevance in children, on the strength of a 15 year observation. Long time period can represent a limit due to population characteristics changing; a selection bias could also be present due to hospitalized only patient analysis. However, we documented variable evolution of chemoresistance and a peculiar serotype spreading, offering microbiological basis for an appropriate clinical approach
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