738 research outputs found
Indice dei passi anneani citati
No full textIndice dei passi anneani citati posto in appendice al volume degli Atti del Convegno internazionale: Gli Annei. Una famiglia nella storia e nella cultura di Roma imperiale (Milano-Pavia, 2-6 maggio 2000, a cura di I. Gualandri e G. Mazzoli), Como, New Press 2003. Alberto Canobbio ha curato l'editing del volume per quanto riguarda la sezione pavese del Convegno
Hyaluronan synthases posttranslational regulation in cancer
No full textHyaluronan (HA) is a critical component of cancer microenvironment that is known to increase tumor progression and aggressiveness. The synthesis of HA starts from the cytosolic precursors UDP N-acetylglucosamine and UDP-glucuronic acid. These two sugar nucleotides have several functions in addition to glycoconjugate synthesis and glucuronidation reactions, each of which can have a critical role in cancer. HA is synthesized by a family of three HA synthase (HAS) enzymes and, in this review, we described the main posttranslational modifications that are known to regulate HA metabolism. In particular, as the main HAS in adult tissues is HAS2, we focused on the role of AMPK-mediated phosphorylation and glycosylation by O-linked N-acetylglucosamine (O-GlcNAcylation) of HAS2 which mediate HAS2 inactivation and activation, respectively. HA catabolism, furnishing glucuronic acid and N-acetylglucosamine, can represent for a cancer cell a valid source of substrates to sustain complex tumor metabolism, and we highlight a presumable metabolic fate of such sugars in tumor cells
Novel insights into matrix pathobiology regulatory mechanisms in health and disease
No full textMatrix macromolecules exhibit leading roles in tissue properties, physiological processes, as well as the development and progression of several diseases. This thematic series covers emerging areas of research in the matrix macromolecule field and includes epigenetics, stem cells, microRNAs, as well as proteoglycan interactions with proteolytic enzymes. Current knowledge of these aspects will elucidate their regulatory mechanisms in pathophysiology and aid the design of novel pharmacological agents. Accompanied by a podcast, listen now. Or listen in iTunes
Lo «Zibaldone» di Alberto Caracciolo: tra teoria e filosofia
No full textIl saggio rintraccia nello Zibaldone di Giacomo Leopardi uno dei principali ipotesti teoretici della flosofa di Alberto Caracciolo. In particolare, attraverso un’analisi testuale e comparata
di alcuni passi dedicati al nichilismo, si dimostrerà come il nulla leopardiano costituisca per Caracciolo un momento di fondazione dell’essere, teso alla realizzazione sintetica del rapporto dialettico
da parte del soggetto conoscente tra poiesis e noesis, tra il nulla religioso e l’imperativo dell’eternoAlberto Caracciolo’s «Zibaldone»: between Theory and Philosophy · The essay traces in Giacomo Leopardi’s Zibaldone one of the main theoretical subtexts of Alberto Caracciolo’s philosophy.
Specifcally, through a textual and comparative analysis of some passages dedicated to nihilism, I
will show how the Leopardian nothingness constitutes for Caracciolo a moment of foundation of
being, aimed at the synthetic realization of the dialectical relationship by the knowing subject between poiesis and noesis, between the religious nothingness and the imperative of the eternal
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