4,268 research outputs found
Lamotrigine in typical absence epilepsy
No full textLamotrigine (LTG) is an anti-epileptic drug effective in partial seizures and generalized epilepsy. There is growing evidence of the usefulness of LTG in childhood (CAE) or juvenile (JAE) absences resistant to previous treatment. In this study all patients were identified using strict diagnostic criteria and subdivided into two groups. (1) Eight patients affected by absence seizures resistant to valproic acid or ethosuximide, received LTG as an-add-on therapy, (2) seven patients affected by typical absence seizures not previously treated, received LTG monotherapy after the diagnosis. In the patients with resistant absence seizures, a full control of seizures was obtained. In five of them, after a mean period of 12.5 months, the previous anti-epileptic drugs were withdrawn leaving the patients on LTG monotherapy. In one patient, absences relapsed and valproic acid was therefore added again to LTG to regain control of the seizures. In six of the seven patients on LTG monotherapy after the diagnosis, a full control of seizures was obtained. In the seventh patient the drug was stopped due to a skin rash.
In conclusion LTG appears to be effective in resistant absence seizures in combination with valproic acid. Moreover, our preliminary data suggest that lamotrigine might be used as monotherapy in typical absence seizures. The advantages and disadvantages of LTG monotherapy in this type of epilepsy are discussed
CVD precursors for transition metal oxide nanostructures: molecular properties, surface behavior and temperature effects
No full textIntegrated analyses on a series of β-diketonate-diamine transition metal complexes (M = Fe, Co, Cu, Zn), highlight the metal center influence on molecular physicochemical properties and provide understanding of the favorable behavior of these complexes as metal sources in the CVD growth of metal/metal oxides nanomaterials. The Zn complex, which shows the most symmetric coordination
environment in the gas phase, is activated in contact
with the heated CVD growth surface model. First principles simulations evidenced surface-induced rolling motion of the Zn precursor in the 363-750 K range, suggesting the relevance of vibrationally excited molecular rolling as activation pathway in high temperature surface chemistry
Dethreading of a Photoactive Azobenzene-Containing Molecular Axle from a Crown Ether Ring: A Computational Investigation
No full textPseudorotaxanes formed by a dibenzo[24]crown-8 ring (R) and a dialkylammonium axle bearing either two E- or two Z-azobenzene units (EE-A or ZZ-A) revealed useful for the construction of light-powered molecular machines and motors, as they provide the opportunity of photocontrolling self-assembly/disassembly processes. The potential energies profiles for the dethreading of these complexes have been investigated by adopting a combination of first-principles molecular dynamics, metadynamics and quantum-chemical geometry optimization approaches. While the dethreading of the EE-A axle is associated with a monotonic energy increase, for that of the ZZ-A axle a transition state and an intermediate structure, in which the components are still threaded together, are found. The rate determining step for the dethreading of the ZZ axle has a higher energy barrier than that of the EE axle, in agreement with the experimental kinetic data. Moreover, the results suggest that the elliptic shape of the ring cavity is important for discriminating between the E and Z terminal azobenzene during dethreading
Translating foreign space and landscape: The Mother by Grazia Deledda
No full textThe Spatial Turn in Translation Studies (Italiano 2015, 4) is pointing out that translation is not just a matter of cultural transfer but a place where new spaces are created (Wolf 2002). In narrative texts, the text world is negotiated by both the author and the reader through discourse, but the translator makes such negotiation more complex. The translation of space and landscape can thus shape the image (hence, the reception) of foreign authors in the target culture, thereby reinforcing the interest in translation as a key player in world literature (Bassnett 2018). This paper draws on this framework to conduct an ecostylistic analysis of space and landscape in the English translation of Grazia Deledda’s novel La Madre.
Deledda’s language of space originates from a subjective perception and performs a clear narratological function. In translation, however, the source author’s identity overlaps with the translator’s subjectivity, which impacts on the target text with political and ideological consequences (Venuti 1995). The reinterpretation of space and the rewriting process are then affected by the translator’s identity, the relationship between central and peripheral cultures and the consequent ideological and cultural issues. In order to discover whether Sardinia changes when filtered through the translator’s mind, culture and language, this paper will focus on a contrastive analysis of The Mother (La Madre), published in 1922. The translational choices related to space, nature and landscape – as features affecting intercultural communication and the reception of foreign authors – will be discussed with a view to understanding if and how the perception of Sardinia changes from source to target text
Susceptibility of the honeybee (Apis mellifera L.) to entomopathogenic bacterial toxins used for the biological control
No full textPredation risk of the sea urchin Paracentrotus lividus juveniles in an overfished area reveal system stability mechanisms and restocking challenges
No full text
- …
