1,439 research outputs found
Chiarezza e sinteticità degli atti tra penne stilografiche, copia e incolla e intelligenza artificiale: Italo Calvino per la difesa del Lògos del diritto
No full text1. Il diritto come Lògos. 2. La tecnologia come opportunità e come rischio: memoria di massa e cervelli all’ammasso. 3. Copincollando verso l’Abisso. 4. Neoluddismo informatico o pacifica convivenza. 5. La Statistica come reparto frodi della Matematica. 6. I talismani di Italo Calvino per il diritto del Terzo Millennio
L'università italiana dopo un quindicennio di riforme
No full textLe novità introdotte dai governi di destra, ma anche dalla sinistra,
basate su una narrazione falsa sui difetti degli atenei nazionali.
Altrettanto falsa la positività dei risultati dei nuovi sistemi di valutazione.
L’Università ora è meno finanziata, più gerarchica e con più precariato.
I dati su crescita di impatto e produttività inficiati dalle “autocitazioni”.
Cresce la fuga dei cervelli
Le specie mediterranee finalizzate a una gestione semplificata delle alberature cittadine
No full textL'analisi è volta ad individuare pregi e difetti delle specie mediterranee utilizzabili nelle alberature cittadine, focalizzando l'attenzione dove effettivamente si può raggiungere un risultato più che soddisfacente, contribuendo all'ecologia del paesaggio e riducendo gli oneri manutentivi a carico delle amministrazioni
A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity
No full textChronic oxidative stress, which occurs in brain tissues of HIV-infected patients, is involved in the pathogenesis of HIV-associated dementia. Oxidative stress can be induced by HIV-1-secreted proteins, either directly or indirectly through the release of cytotoxic factors. In particular, HIV-1 Tat is able to induce neuronal death by interacting with and activating the polyamine-sensitive subtype of the NMDA receptor (NMDAR). Here, we focused on the role of polyamine catabolism in Tat-induced oxidative stress in human neuroblastoma (SH-SY5Y) cells. First, Tat was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO). Second, Tat was observed to increase SMO activity as well as decreasing the intracellular spermine levels. Third, Tat-induced SMO activation was completely prevented by the NMDAR antagonist MK-801, clearly indicating an involvement of NMDAR stimulation. Finally, pretreatment of cells with N-acetylcysteine, a scavenger of H2O2, and with MK-801 was able to completely inhibit reactive oxygen species formation and to restore cell viability. Altogether, these data strongly suggest a role for polyamine catabolism-derived H2O2 in neurotoxicity as elicited by Tat-stimulated NMDAR
Correzione dell ’ipersplenismo nella cirrosi epatica ascitogena quale premessa essenziale per l’applicazione dello shunt peritoneo venoso
No full text
pMSSM combination of SUSY searches at the LHC
No full textpMSSM combination of SUSY searches at the LH
Search for lepton flavor violating decay τ<sup>-</sup> →ℓ<sup>-</sup>ℓ<sup>+</sup>ℓ<sup>-</sup>ℓ = e, μ at BaBar
No full textThe Standard Model (SM) is one of the most tested and verified physical theories of all time, present experimental observations are consistent with SM expectations. On the other hand SM can not explain many physical observations: the cosmological observations possibly infer the presence of dark matter which is clearly beyond the SM expectations; the SM Higgs model, while explaining the generation of fermion masses, can not explain the hierarchy problem and a non natural fine tuning of SM is needed to cancel out quadratic divergences in the Higgs boson mass. New physics (NP) beyond SM should hence be investigated: rising the energy above NP processes thresholds, and detecting new particles or new effects not predicted by the standard model directly, is one of the possible approaches; another approach is to make precision measurements of well known processes or looking for rare processes which involve higher order contribution from NP processes, this approach need higher luminosities with respect to the previous approach but lower beam energies. Search for Lepton Flavor Violation (LFV) in charged lepton decays is promising: neutrino physics provides indeed a clear and unambiguous evidence of LFV in the neutral lepton sector via mixing processes, which have been observed for the first time by the Homestake collaboration. We expect LFV in the charged sector as well, both in {mu} and {tau} sector, but current experimental searches for LFV processes did not find any evidence for those processes, and more results are expected to come from new experiments in the coming years
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