1,722,633 research outputs found
Premessa dei Curatori
No full textQuesto volume intende omaggiare Marcello Garzaniti in occasione del suo sessantesimo compleanno e del trentennale della sua carriera, a riconoscimento dell’impegno generosamente profuso nell’ambito della ricerca, della divulgazione scientifica e della didattica. L’eterogeneità dei contributi offerti da colleghi, allievi e amici testimonia l’erudizione e la poliedricità d’interessi del festeggiato. Le cinque sezioni di cui si compone il volume spaziano infatti dalla storia della cultura alla storia della civiltà letteraria slava ecclesiastica, dalla linguistica alle letterature slave, senza trascurare la storia della slavistica. Il volume è completato dalla bibliografia della produzione scientifica di Marcello Garzaniti
COVID-19: An Appeal for an Intersectoral Approach to Tackle With the Emergency
Full text linkThe knowledge of disease determinants is a pre-requisite for disease prevention. Infectious diseases determinants can be classified in three ways, as: primary or secondary; intrinsic or extrinsic; and associated with host, agent, or environment. In the specific case of COVID-19 several of these determinants are currently unknown leading to difficulties in public health approach to this disease. In this paper, we attempt to address several of the current gaps on COVID-19 using a systematic analysis on recent findings and some preliminary knowledge on animal coronaviruses. A discussion on the impact of COVID-19 determinants in disease prevention and control will be based on the Environmental Change and Infectious Disease (EnVID) systemic framework to address several challenges that may affect the control of the SARS- CoV-2 pandemic spread both in industrialized and in developing Countries
The construction of Karen Karnak: The multi-author-function
No full textThis thesis is situated within the comparatively recent developments of Web 2.0 and the emergence of interactive WikiMedia, and explores the mode of authorship within a Read/Write culture compared to that of a Read/Only tradition. The hypothesis of this study is that the role of the audience has become merged with the author, and as such, represents new functions and attributes, distinct from a more conventional concept of authorship, in which the roles of audience and author are more separate. Read/Write and participatory culture, as defined by this study, is focused on collaboration, and includes the influences of D.I.Y. culture, Open-Source practices and the production of text by multiple authors. Multi-authorship presents a re-thinking of several concepts which support the notion of the individual author, since the focus of multi-authorship is not on attribution and ownership of a finished text, but on the continued malleability of a text. Modes of multi-authorship, demonstrated in the use of the pseudonyms Alan Smithee and Karen Eliot, represent declarative authors whose names signify multiple origins, whilst concurrently indicating a distinct body of work. The function of these names form an important context to this study, since primary research involves the construction of an experimental mode of multi-authorship utilising WikiMedia technology and the interaction of thirty nine participants, who are invited to create a body of work under the collective pseudonym Karen Karnak. The data generated by this experiment is analysed using aspects of Michel Foucault's author-function to identify and determine power structures inherent in the WikiMedia context. The interplay of power structures, including concepts such as identity, ownership and the body of work, affect the resulting mode of authorship and contribute to the construction of Karen Karnak, suggesting further areas of research into the emerging multi-author
Commento agli artt. 2-4, 23 e 24 della legge fallimentare
No full textIl contributo contiene un commento in materia di liquidazione coatta amministrativa e di poteri e competenza del tribunale fallimentare
Risk factors and prevention of hepatocellular carcinoma in HCV infection
No full textAbstract
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Several risk factors for HCC development have been identified, including cirrhosis, hepatitis B virus (HBV) infection, and hepatitis C virus (HCV) infection. With regard to cirrhosis, multivariate analysis indicates that alcohol abuse, HBsAg positivity, and anti-HCV seropositivity are independent variables associated with an increased risk for HCC in the cirrhotic patient. A close relationship between chronic HBV infection and HCC has been established by epidemiological studies and laboratory investigations. Evidence indicates that HCV also plays a leading role in development of HCC. Most patients with HCV-related HCC develop the tumor as a consequence of long-standing infection accompanied by chronic and progressive liver damage. In our study of 290 consecutive patients with cirrhosis, patients with persistently elevated or fluctuating ALT levels had a significantly greater rate of HCC development. The mechanism of HCC development in HCV infection remains to be elucidated. The annual cumulative risk of developing HCC is approximately 1% in patients without cirrhosis at inclusion and 3-10% in those with cirrhosis, depending on the stage of cirrhosis and presence of etiological cofactors. Although some evidence suggests that patients infected with the HCV genotype 1b are at increased risk for development of more severe liver disease, including HCC, results of our prospective study do not support a difference between cirrhotic and noncirrhotic patients in terms of the natural course of cirrhosis and the rate of developing HCC based on genotype. Strategies to prevent HCV-related HCC include blood screening and treatment of chronic HCV infection with interferon-alpha. Recent studies suggest that interferon-alpha treatment may prevent the development of HCC in HCV infection. Further research is warranted
Natural history of chronic hepatitis B
No full textChronic hepatitis B virus infection can cause chronic hepatitis, cirrhosis, liver failure and hepatocellular carcinoma. Chronic hepatitis B is characterized by an early replicative phase with hepatitis B e antigen positivity, high serum HBV-DNA levels and disease activity (HBeAg positive chronic hepatitis) and a late inactive phase with anti-HBe seroconversion, low or undetectable serum HBV-DNA and liver disease remission (inactive carrier state). Another form is characterized by active disease due to HBV variants not expressing HBeAg (HBeAg negative chronic hepatitis). Both types of chronic hepatitis B can lead to cirrhosis and its complications. The incidence of cirrhosis is 2-5/100 person years, but may be as high as 8-10 in HBeAg negative cases. The incidence of HCC varies geographically and increases with the duration and severity of liver disease (0.1-8/100 person years). The prognosis is reasonably good in compensated cirrhosis, but very poor following decompensation. Viral, host and environmental influence the natural history of chronic hepatitis B and explain the heterogeneity of its clinical outcomes
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