1,722,057 research outputs found
Nucleolus: A Liquid Droplet Compartment for Misbehaving Proteins
No full textA new study reports an unexpected function of the nucleolus as a protein quality control compartment for misfolded and aggregation-prone proteins. These findings have important implications for protein misfolding diseases
Near Earth Objects Deflection Strategies: a Multicriteria Comparison for the Target Asteroid 2023 PDC
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The forgotten variables of DNA array hybridization
No full textAbstract
The reproducibility and reliability of DNA array measurements have been repeatedly questioned during the years. A reassessment of fundamental variables of nucleic acid hybridization might help to solve some of these problems. The hybridization equilibrium, t(1/2), is 41 days for a target human genome. Similar hybridization t(1/2) are expected for whole-transcriptome chips hybridized with tissue cDNA. This implies that most studies on mammalian cells have not been performed under equilibrium conditions. Non-equilibrium binding introduces a stochastic factor into hybridization dynamics; in other words, hybridization will prevail at different spots in different experiments, everything else being equal. A careful re-evaluation of results obtained under non-equilibrium conditions might prove fruitful and help to explain instances where findings conflict
Architecture-territory for the urban design, 1970-2016
No full textThe debate developed during the 70s of the twentieth century around the planning of the University of Cagliari in the territory of the wide area, matures in a cultural and national climate particularly rich in experiences, some of which are proposed by great Italian protagonists of architecture in the Italian peninsula. Significant in this context is the competition project won by Vittorio Gregotti - coordinator of the project team, made up of Emilio Battisti, Hiromichi Matsui, Pierluigi Nicolin, Franco Purini, Carlo Rusconi Clerici and Bruno Viganò - for the University of Calabria (1974), achieved starting from 1977.
In these same years the University of Cagliari is launching a design competition for the construction of a university and hospital center in the territory of the first urban belt of the capital of Sardinia (composed by some little cities: Elmas, Monserrato, Quartucciu, Selargius, Sestu, Pirri), where compact city, with some timid and limited residential projects in the first suburbs, gave way to the campaign, and to an economy even based on agriculture and wine production. The competition was won by Luisa Anversa Ferretti, architect learner of the “Roman school” who coordinated the group
consisting of Pierluigi Malesani, Giuseppina Marcialis, Giuseppe and Marcello Rebecchini, Giangiacomo d'Ardia, Dario Passi and Livio Quaroni. The proposal is very ambitious; it doesn’t only tried to make sure that the university took hold in the territory, responding fully to the objectives of the call, but proposed a diffusion process of the functions and of the structure of the territory to the large scale: an utopia capable of looking at the future to design its own present.
Outcomes of the project prove less mature then original proposal. The project was realized only in part, losing the positivist vision of territorial control through architecture (architecture-territory).
The morpho-typological studies, advanced during the competition and later deepened in the preparation of the Master Plan of the University of Cagliari – drawn up by the same design team -not find any concrete results; so, in the in the 80s of '900, a process of abandonment of the campaign advanced, and it will favor, since the same years, the urban sprawl with settlements characterized by fragmented tissues. An archipelago of small settlements starting from the urban density of the cities of the first crown of Cagliari.
The urban-rural dichotomy weakens and the territory becomes an uncontrolled urban.
The study on the large scale of this territory is often taken up by some planning tools drafted by involved municipalities; however, these tools do not reach an effective implementation. The same advanced strategies from the study for the Ecomuseum of The Rural Landscape, "The covenant by which a community is committed to take care of a territory, preserving and working to increase its value" (Maggi, 2002), which concerns a large part of this territory (Selargius, Monserrato, Quartucciu, Settimo San Pietro), will only have the merit of bringing the attention of the community towards the needs of project on big and small scale, open and aimed in perspective, as it was proposed in the past, linked to the productivity of the agricultural production sector, placing the landscape as the first item of value.
But it is with the reorganization of the metropolitan areas, implemented by law n°. 56 of April 7, 2014, that there was a political convergence of intent towards a shared project of territory by the local governments interested in this issue. From this moment some interests, studies and projects ripen in order to exploring the possibilities for enhancement of this vast territory with a return to a careful look at local conditions.
The paper proposes a reading of this urban temporality (1970-2016) starting from the needs of the present, by verifying the actuality of past experience; at the same time it proposes some design studies, developed between different scales, in the biennium of university research 2013-2015.
The goal is to understand if the urban project may be the most effective tool in the management of times and scales of transformation of the contexts; an open project that shows attention to the needs of development of a large part of the territory, to the aspirations of the communities and to the values of the places expressed in terms of memory and identity.
The contribution is concluded with some experiences of project characterized by different scales which faced morpho-typological aspects on the large scale
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