754 research outputs found
Paula : [Portraits of Paula Beer-Hofmann].
No full textThe name "Paula" is written in gold on the hard cover of this album. The photographs depict Paula Beer-Hofmann as a teenager and in her twenties, dressed in various outfits, sometimes with her hair up, other times with her hair down, sometimes in hats, sometimes with her daughter Miriam. Profile portraits and forward-facing portraits are included. Inscriptions on the photographs note Paula's age and the location, where the photograph was taken, most commonly in Vienna. Some photographs were taken in Atelier d’Ora in Vienna, others by Perscheid in Berlin.The following photographs are included in this album: F 10015, F 10016, F 10017, F 10018, F 10019, F 10020, F 10021, F 10022, F 10023, F 10024, F 10024A, F 10025, F 10026, F 10027, F 10028, F 10029, F 10030, F 10031, F 10032, F 10033, F 10034, F 10035, F 10036, F 10037, F 10038, F 10039, F 10040, F 10041, F 10042Paula (Pauline) Lissy was born in Vienna, Austria in 1879. In 1897 she married the author Richard Beer-Hofmann; their daughter Miriam Beer-Hofmann Lens was born in the same year.Digital Imag
Theatrical performance of the play "Outward bound".
No full textRichard Beer-Hofmann’s debut as a director at “Theater in der Josefstadt” was a 1923 play by the English author Sutton Vane.Digital ImageThe following photographs are contained in this album: F 9131, F 9132, F 9133, F 9134, F 9135, F 9136, F 9137, F 9138, F 9139, F 9140, F 9141, F 9142, F 9143, F 9144, F 9145, F 9146, F 9147, F 9148, F 9149, F 9150, F 9151, F 9152, F 9153, F 9154, F 9155, F 9156, F 9157, F 9158, F 9159, F 9160, F 9161, F 9162, F 9163, F 9164, F 9165, F 9166, F 9167, F 9168, F 9169, F 9170reviewedDigital Imag
An open mapping theorem
No full textIt is proved that any surjective morphism f : Z(k) -> K onto a locally compact group K is open for every cardinal k. This answers a question posed by Hofmann and the second author
Author response
No full textTranscription regulation in metazoans often involves promoter-proximal pausing of RNA polymerase (Pol) II, which requires the 4-subunit negative elongation factor (NELF). Here we discern the functional architecture of human NELF through X-ray crystallography, protein crosslinking, biochemical assays, and RNA crosslinking in cells. We identify a NELF core subcomplex formed by conserved regions in subunits NELF-A and NELF-C, and resolve its crystal structure. The NELF-AC subcomplex binds single-stranded nucleic acids in vitro, and NELF-C associates with RNA in vivo. A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo. These results reveal the three-dimensional architecture and three RNA-binding faces of NELF
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Gastrolithiasis in prehensile-tailed porcupines (Coendou prehensilis): Nine cases and pathogenesis of stone formation
No full textGastrolithiasis was diagnosed in nine prehensile-tailed (PT) porcupines (Coendou prehensilis) housed at six zoologic institutions in the United States and Canada. Affected animals were either asymptomatic or had clinical signs, including weight loss, diarrhea, and depression. Abdominal palpation was adequate for diagnosis in all six antemortem cases, and radiographs confirmed a soft tissue density mass effect produced by the concretion. These gastroliths were all successfully surgically removed. Recurrence of gastrolith formation was common and occurred in four of the cases. Three cases were diagnosed postmortem, with the gastrolith causing gastric perforation in one case. Gastroliths from four cases were identified by mass spectrometry as bile acid precipitates consisting of the insoluble acid form of endogenous glycine-conjugated bile acids
Very high energy follow-up programs of gravitational wave and transient alerts with the MAGIC telescopes
No full textAfter 100 years from Einstein's formulation of general relativity, the O1 LIGO-Virgo science run provided the first direct detection of gravitational waves. The MAGIC telescopes, observing in the very high energy band (VHE ≳ 100 GeV), participate to the vast collaboration of electromagnetic facilities that follow up candidate gravitational waves events. In the next months the aLIGO and aVIRGO detectors will approach their design sensitivity, and an increasing number of gravitational waves detections is expected. The observations in, both, gravitational waves and electromagnetic channels will play a key role in our understanding of the physics of these transient events, yielding a rich scientific output. By taking advantage of its fast slewing, large efflective area, and sensitivity, MAGIC could provide important information on the gravitational waves counterpart in an energy range not afflected by selective absorption processes typical of other wavelenghts in the redshift range covered by the GW detectors for the various plausible classes of sources. © 2017 Author(s)
When running is easier than walking: effects of experience and gait on human obstacle traversal in virtual reality
No full textHofmann F, Dürr V. When running is easier than walking: effects of experience and gait on human obstacle traversal in virtual reality. Experimental Brain Research . 2022;240(10):2701–2714.Humans readily traverse obstacles irrespective of whether they walk or run, despite strong differences between these gaits. Assuming that the control of human obstacle traversal may be either gait-specific or gait-independent, the present study investigates whether previous experience in an obstacle traversal task transfers between the two gaits, and, if this was the case, whether transfer worked both ways. To this end, we conducted a within-group comparison of kinematic adjustments during human obstacle traversal in both walking and running, with distinct participant groups for the two gait sequences. Participants (n=12/12(f/m), avg.25yo) were motion captured as they traversed obstacles at walking and running speeds on a treadmill, surrounded by an immersive virtual reality (VR) environment. We find that kinematics recorded in our VR setup are consistent with that obtained in real-world experiments. Comparison of learning curves reveals that participants are able to utilize previous experience and transfer learned adjustments from one gait to another. However, this transfer is not symmetrical, with previous experience during running leading to increased success rate in walking, but not the other way round. From a range of step parameters we identified lacking toe height of the trailing leg as the main cause for this asymmetry. © 2022. The Author(s)
Letter. Late cretaceous seasonal ocean variability from the arctic
No full textThe modern Arctic Ocean is regarded as barometer of global change and amplifier of global warming1 and therefore records of past Arctic change are of a premium for palaeoclimate reconstruction. Little is known of the state of the Arctic Ocean in the greenhouse period of the late Cretaceous, yet records from such times may yield important clues to its future behaviour given current global warming trends. Here we present the first seasonally resolved sedimentary record from the Cretaceous from the Alpha Ridge of the Arctic Ocean. This “paleo-sediment trap” provides new insights into the workings of the Cretaceous marine biological carbon pump. Seasonal primary production was dominated by diatom algae but was not related to upwelling as previously hypothesised. Rather, production occurred within a stratified water column, involving specially adapted species in blooms resembling those of the modern North Pacific Subtropical Gyre, or those indicated for the Mediterranean sapropels. With increased CO2 levels and warming currently driving increased stratification in the global ocean, this style of production that is adapted to stratification may become more widespread. Our evidence for seasonal diatom production and flux testify to an ice-free summer, but thin accumulations of terrigenous sediment within the diatom ooze are consistent with the presence of intermittent sea ice in the winter, supporting a wide body of evidence for low temperatures in the Late Cretaceous Arctic Ocean, rather than recent suggestions of a 15 °C mean annual temperature at this time
The bile acid TGR5 membrane receptor: From basic research to clinical application
No full textAbstractThe TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord, and the enteric nervous system. The effect of TGR5 activation depends on the tissue where it is expressed and the signalling cascade that it induces. Animal studies suggest that TGR5 activation influences energy production and thereby may be involved in obesity and diabetes. TGR5 activation also influences intestinal motility. This review provides an overview of TGR5-bile acid interactions in health as well as the possible involvement of TGR5 in human disease
- …
