15,928 research outputs found
La Palmyra di Khalid Muhammad al-As'ad
No full textAnalisi delle principali ricerche svolte da Khalid al-As'ad a Palmira, nella seconda metà del Novecento
Nonalcoholic Fatty Liver Disease, Cardiovascular Risk, and Carotid Inflammation
No full textNonalcoholic fatty liver disease (NAFLD) is defined by excessive triglycerides (TGs) accumulation in the liver (>5% of hepatocytes histologically) in the absence of alcohol excess. The NAFLD ranges from simple steatosis to steatohepatitis and cirrhosis. The NAFLD and nonalcoholic steatohepatitis (NASH) are now the number one cause of liver disease in Western countries. The prevalence of NAFLD is increasing but is underreported, and the epidemiology and demographic characteristics vary worldwide.2 The prevalence is increasing because of the rising occurrence of obesity and type 2 diabetes (T2DM); in fact, NAFLD is considered as the hepatic manifestation of metabolic syndrome (MetS).Fil: Al-Rasadi, Khalid. Sultan Qaboos University Hospital. Department of Clinical Biochemistry; OmánFil: Rizzo, Manfredi. Universidad de Palermo; ArgentinaFil: Montalto, Giuseppe. Universidad de Palermo; ArgentinaFil: Berg, Gabriela Alicia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin
Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies
No full textThe definition of "Metabolic Associated Fatty Liver Disease - MAFLD" has replaced the previous definition of Nonalcoholic Fatty Liver Disease (NAFLD), because cardiometabolic criteria have been added for the prevention of cardiological risk in these patients. This definition leads to an in-depth study of the bidirectional relationships between hepatic steatosis, Type 2 Diabetes Mellitus (T2DM), Cardiovascular Disease (CVD) and/or their complications. Lifestyle modification, which includes correct nutrition combined with regular physical activity, represents the therapeutic cornerstone of MAFLD. When therapy is required, there is not clear accord on how to proceed in an optimal way with nutraceutical or pharmacological therapy. Numerous studies have attempted to identify nutraceuticals with a significant benefit on metabolic alterations and which contribute to the improvement of hepatic steatosis. Several evidences are supporting the use of silymarin, berberine, curcumin, Nigella sativa, Ascophyllum nodosum, and Fucus vesiculosus, vitamin E, coenzyme Q10 and Omega-3. However, more evidence regarding the long-term efficacy and safety of these compounds are required. There is numerous evidence that highlights the use of therapies such as incretins or the use of Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors or other similar therapies which, by assisting existing therapies for pathologies such as diabetes, hypertension, insulin resistance, have given a breakthrough in prevention and the reduction of cardiometabolic risk. This review gave an overview of the current therapeutic strategies that are expected to aid in the treatment and prevention of MAFLD
Beneficial Effect of Statin Therapy on Arterial Stiffness
No full textArterial stiffness describes the increased rigidity of the arterial wall that occurs as a consequence of biological aging and several diseases. Numerous studies have demonstrated that parameters to assess arterial stiffness, especially pulse-wave velocity, are predictive of those individuals that will suffer cardiovascular morbidity and mortality. Statin therapy may be a pharmacological strategy to improve arterial elasticity. It has been shown that the positive benefits of statin therapy on cardiovascular disease is attributable not only to their lipid-lowering capacity but also to various pleiotropic effects, such as their anti-inflammatory, antiproliferative, antioxidant, and antithrombotic properties. Additionally, statins reduce endothelial dysfunction, improve vascular and myocardial remodeling, and stabilize atherosclerotic plaque. The aim of the present review was to summarize the evidence from human studies showing the effects of statins on arterial stiffness
Retrospective study on the emotional status of healthcare workers in a COVID-19 field hospital in Oman
No full textOverview: To combat the overwhelming demand for medical services and care during the COVID-19 Pandemic, the Sultanate of Oman launched the COVID-19 Field Hospital in 2020, designed to respond and alleviate the burden on the medical infrastructure. Several studies globally and from the Middle East suggested that frontline healthcare workers (HCW) were at risk of developing markers of psychological distress. It was further understood through research findings that HCW were resilient during times of crisis. However, there is a dearth in studies evaluating the emotional status of frontline HCW posted in the COVID-19 field hospitals in Gulf Countries, including Oman. This study attempts to shed light on the emotional status of HCW that were on the frontlines in the field hospital in the Sultanate of Oman. Aim: This study aims to quantify and evaluate the emotional status of HCW in the frontline field hospital by screening for symptoms of depression, anxiety, and sleep quality. Method: The data was collected by a local private mental healthcare facility as part of digital feedback to design and implement supportive strategies. Data was collected between September 2021 and October 2021 from 121 HCW in the COVID-19 Field hospital in Oman via ‘WhatsApp’. Results: Chi square and binary logistic regression tests were administered to evaluate the data. The participants comprised of 63.6% females and 79.3% were between 30 and 39 years of age. Majority of the participants (65.2%) described themselves as ‘financially unstable’ and possess an average of 7.5 years of work experience. Of the participants 73.6% of the HCW were based solely in the field hospital for 6–9 months at the time of the survey. Majority of the participants denied the presence of emotional distress expressed through depression (92.6%), anxiety (92.6%) and poor quality of sleep (59.5%). Conclusion: The findings of the present study reflect the HCW ability to cope during challenging situations likely owing to a variety of environmental, social and personal protective factors. The findings of this study can translate into further research on identifying and addressing stressors and targeting the enhancement of protective factors to safeguard the well-being of HCW
The role of statins in the differentiation and function of bone cells
No full textStatins are 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA( reductase inhibitors blocking cholesterol biosynthesis in hepatic cells, thereby causing an increase in low-density lipoprotein (LDL) receptors resulting in enhanced uptake and clearance of atherogenic LDL-cholesterol (LDL-C) from the blood. Accordingly, statins decrease the risk of developing atherosclerosis and its acute complications, such as acute myocardial infarction and ischemic stroke. Besides the LDL-C-lowering impact, statins also have other so-called pleiotropic effects. Among them, the ability to modulate differentiation and function of bone cells and exert direct effects on osteosynthesis factors. Specifically, earlier studies have shown that statins cause in vitro and in vivo osteogenic differentiation. Statins increase the expression of many mediators involved in bone metabolism, including bone morphogenetic protein-2 (BMP-2), glucocorticoids, transforming growth factor-beta (TGF-beta), alkaline phosphatase (ALP), type I collagen, and collagenase-1. As a result, they enhance bone formation and improve bone mineral density by modulating osteoblast and osteoclast differentiation. This review article summarizes the literature exploring bone-related "pleiotropic" effects of statins and suggesting an anabolic role in the bone tissue for such a drug class. Accordingly, current knowledge encourages further clinical trials to assess their therapeutic potential in the treatment of bone disorders, such as arthritis and osteoporosis
Protective Effects of Curcumin on Endothelium: An Updated Review
No full textEndothelial dysfunction is the common early stage of most cardiovascular afflictions. The endothelium is considered the main mediator of vascular homeostasis via its vasodilator, anti-inflammatory and anticoagulant properties. Among the different endothelial-derived mediators, nitric oxide is produced by nitric oxide synthase and has a critical role in regulating endothelial function. Physiological and pathological processes such as aging and diabetes mellitus are associated with disturbances of endothelial function which, at least at the earliest stage, can be reversed by lifestyle and pharmacological intervention to reduce the risk of incident cardiovascular diseases. Among dietary strategies, curcumin is a cheap and safe nutraceutical polyphenol with proven antioxidant and anti-inflammatory properties. Given the important role of such processes in the development of endothelium dysfunction, a role for curcumin in the prevention or treatment of this condition has been hypothesized. This review summarizes the available literature on the beneficial role of curcumin on vascular endothelial function
Tradisi Fiqh dalam Pemikiran Khalid Abu Al-Fadl
No full textThis research is descriptive and reflective, with lifting the theme "Tradition Fiqh Thought Khalid Abu al-Fadl", the theme is intended to explore the key ideas of Khalid discourse on contemporary Islamic legal by analyzing one of his main work, Speaking in God's Name: Islamic Law, Authority, and Women.dengan using content analysis approach to examine in depth the ideas Khalid Abu al-Fadl of Islamic law, the results of this study is the ideology of Salafism Khalid Critics argue that Islamic reformism partly responsible for creating credo closed, intolerant, and shallow in understanding the sacred texts of Islam deserves to be taken seriously.
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Keywords: Fiqh, Khali
Statins and the COVID-19 main protease: in silico evidence on direct interaction
No full textIntroduction: No proven drug and no immunisation are yet available for COVID-19 disease. The SARS-CoV-2 main protease (Mpro), a key coronavirus enzyme, which is a potential drug target, has been successfully crystallised. There is evidence suggesting that statins exert anti-viral activity and may block the infectivity of enveloped viruses. The aim of this study was to assess whether statins are potential COVID-19 Mpro inhibitors, using a molecular docking study.
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Material and methods: Molecular docking was performed using AutoDock/Vina, a computational docking program. SARS-CoV-2 Mpro was docked with all statins, while antiviral and antiretroviral drugs - favipiravir, nelfinavir, and lopinavir - were used as standards for comparison.
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Results: The binding energies obtained from the docking of 6LU7 with native ligand favipiravir, nelfinavir, lopinavir, simvastatin, rosuvastatin, pravastatin, pitavastatin, lovastatin, fluvastatin, and atorvastatin were -6.8, -5.8, -7.9, -7.9, -7.0, -7.7, -6.6, -8.2, -7.4, -7.7, and -6.8 kcal/mol, respectively. The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds.
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Conclusions: These results indicate, based upon the binding energy of pitavastatin, rosuvastatin, lovastatin, and fluvastatin, that statins could be efficient SARS-CoV-2 Mpro inhibitors. This is supported by the fact that the effects of some statins, especially pitavastatin, have a binding energy that is even greater than that of protease or polymerase inhibitors. However, further research is necessary to investigate their potential use as drugs for COVID-19
Examining the Authorship of Nahj al-Balāgha: Between Ali Ibn Abi Talib, al-Sharif al-Radi, and al-Sharif al-Murtad
No full text"نهج البلاغة" كتاب يُنسَب إلى عليّ بن أبي طالب رضي الله عنه يتضمّن عددًا من الخطب والمواعظ والعهود والرّسائل والحِكَم والوصايا والآداب، توزّعت على 238 خطبة، و 79 رسالة و 489 قولا، يرى الشّيعة في "النّهج" أنّه أحد الكتب المهمّة الّتي يجب على الشّيعي قراءتها والأخذ والتعلّم منها، وقد اختلف الدّارسون والنّقّاد القدامى والمعاصرون في مؤلّـِفه، فمنهم مَن اعتبره لعليّ بن أبي طالب ومنهم من اعتبره للشّريف الرَّضيّ، وفريق ثالث جعله للشّريف المرتضى. تتناول هذه الدراسة بالاستقصاء والتحقّق والتحليل نسبة الكتاب إلى صاحبه أو ما يُزيل الإبهام، هل هو عليّ بن أبي طالب؟ أم الشّريف الرَّضيّ؟ أم الشّريف المرتضى؟ ويحاول أن يرجّح لمن يُنسَب كتاب نهج البلاغة، وما مدى مصداقيـّته؟ وما مدى صحّة نسبة كتاب نهج البلاغة لعليّ، وما رأي الدّارسين والعلماء فيه؟ وما هي أهمّ المطاعن الموجّهة إلى نهج البلاغة؟The book Nahj al-Balagha is a collection of sermons, letters, adages, commandments, and etiquettes, divided into 238 sermons, 79 treatises, and 489 sayings. People following the Shiite sect regard it as a crucial text for teaching and learning, and they attribute it to Ali Ibn Abi Talib. Yet, the book’s real author is still disputed among Sharia scholars. While some attribute it to Ali Ibn Abi Talib, others claim that al-Sharif al-Radi is the book’s actual author, whereas another group attribute it to al-Sharif al-Murtada. This study employs a comprehensive approach to investigate and analyze the book’s authorship. It involves a detailed literary and historical analysis, examining primary sources, scholarly works, and critical literature to explore the real author of the text. It compares the content of the book with other authenticated works belonging to the potential authors in order to identify similarities and differences. By evaluating the style, language, and themes of Nahj al-Balagha, as well as reviewing historical documents and manuscripts, the study aims to trace the text’s origins and transmissions. In doing so, it addresses the significant critiques and controversies surrounding the text, enhancing our understanding of its historical and literary significance. The study further contributes to the ongoing discourse on the book’s authorship, providing more clarity on the topic and promoting additional scholarly research
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