1,720,955 research outputs found
Aromatase mutation in men as a rare cause of osteoporosis: a case report and review of the literature
No full textThe impact of additional TBS measurement on therapy decisions in osteoporosis treatment
Full text linkIntroduction: Primary osteoporosis is a bone disease in aging people that is associated
with an increased likelihood of fractures and is underdiagnosed and undertreated. Sec-
ondary forms of osteoporosis, caused by an underlying disease, can also affect younger
patients. Improving osteoporosis diagnostics can help to identify affected patients early,
treat them in a timely manner and thus avoid fractures. The trabecular bone score (TBS)
is a new method that can be used as a supplement to dual-energy X-ray absorptiometry
(DXA) and indirectly draws conclusions about bone quality. By incorporating both meth-
ods at the same time, the patient's individual risk should be better assessed. The aim of
our work was to examine how well this new additive diagnostic is accepted by patients
and to assess to what extent TBS can help doctors determine the indication for therapy.
Methods: We included 292 patients from an endocrinological-rheumatological medical
care center. This included a high proportion of patients with secondary osteoporosis. Pa-
tients who were eligible for bone mineral density (BMD) measurement had the option of
additional TBS measurement. We analyzed demographic data, leading diagnoses, bone
metabolic parameters, and results of BMD and TBS measurements.
Results: More than 90% of patients agreed to a paid TBS measurement as an adjunct to
DXA. TBS measurement influenced the decision in approximately 40% of patients with
an indication for antiosteoporotic medication. Furthermore, it has been shown that, de-
pending on the underlying disease/risk spectrum, 21–25.5% of patients had an unremark-
able BMD measurement with reduced bone quality in the TBS measurement. A stronger
association was shown between TBS T-score and DXA T-score than between TBS Z-
score and DXA T-score.
Conclusion: We were able to show that TBS is well accepted by patients and influences
the treatment decision in a large group of patients in our special patient population. In
patients with secondary osteoporosis, the use of TBS in addition to DXA seems to be
useful in order to better assess the risk of fracture and thus initiate drug therapy for oste-
oporosis in a timely manner.Einleitung: Die primäre Osteoporose ist eine Knochenerkrankung des alternden Menschen, die mit erhöhter Frakturwahrscheinlichkeit einhergeht und unterdiagnostiziert und untertherapiert ist. Sekundäre Osteoporoseformen, durch eine zugrundeliegende Erkrankung bedingt, können auch jüngere Patienten betreffen. Die Verbesserung der Osteoporose-Diagnostik kann helfen, betroffene Patienten frühzeitig zu erkennen, rechtzeitig zu therapieren und so Frakturen zu vermeiden. Der Trabekuläre Bone Score (TBS) stellt eine neue Methode dar, die als Ergänzung zur Dual-energy X-ray absorptiometry (DXA) verwendet werden kann und indirekt auf die Knochenqualität rückschließt. Durch die gleichzeitige Einbeziehung beider Methoden sollte das individuelle Risiko des Patienten besser eingeschätzt werden können. Das Ziel unserer Arbeit war zu prüfen, wie gut diese neue additive Diagnostik von Patienten angenommen wird, sowie zu beurteilen, inwiefern der TBS Ärzten helfen kann, die Therapieindikation zu stellen.
Methode: Wir haben 292 Patienten aus einem endokrinologisch-rheumatologischen MVZ in unsere Arbeit eingeschlossen. Hierunter war ein hoher Anteil an Patienten mit sekundärer Osteoporose. Patienten, die für eine Knochendichte-Messung (bone mineral density, BMD) in Frage kamen, hatten die Möglichkeit, sich für eine TBS-Messung zu entscheiden. Wir analysierten demografische Daten, führende Diagnosen, Knochenstoffwechselparameter und Ergebnisse der BMD- und TBS-Messungen.
Ergebnisse: Mehr als 90% der Patienten stimmten einer kostenpflichtigen TBS-Messung als Ergänzung zur DXA zu. Die TBS-Messung beeinflusste die Entscheidung bei etwa 40% der Patienten mit einer Behandlungsindikation für antiosteoporotische Medikamente. Des Weiteren hat sich gezeigt, dass je nach zugrundeliegendem Krankheits-/Risikospektrum 21–25,5% der Patienten eine unauffällige BMD-Messung mit reduzierter Knochenqualität in der TBS-Messung hatten. Außerdem hat sich eine stärkere Assoziation zwischen TBS T-Score und dem DXA T Score gezeigt als zwischen dem TBS ZScore und dem DXA T-Score.
Schlussfolgerung: Wir konnten zeigen, dass der TBS gut von den Patienten angenommen wird und die Therapieentscheidung bei einer großen Gruppe von Patienten unseres speziellen Patientenkollektivs beeinflusst. Bei Patienten mit sekundärer Osteoporose scheint der Einsatz von TBS zusätzlich zur DXA sinnvoll zu sein, um das Frakturrisiko besser abzuschätzen und somit rechtzeitig eine medikamentöse Osteoporose-Therapie einzuleiten
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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